Human central nervous system (CNS) ApoE isoforms are increased by age, differentially altered by amyloidosis, and relative amounts reversed in the CNS compared with plasma [PDF]
, 2016 The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain; however, both the amounts and structure of human apoE isoforms have been hypothesized to lead to ...
Baker-Nigh, Alaina T +11 more
core +3 more sources
İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, 2019 Amaç: Ateroskleroz kaynaklı Koroner Arter Hastalığı (KAH), multifaktöriyel ve poligenik kompleks bir hastalıktır. Son yıllarda yapılan çalışmalarda KAH ile ilişkili bazı genetik varyantlar öne çıkmıştır.
Erhan Teker +3 more
doaj +1 more source
Npp1 promotes atherosclerosis in ApoE knockout mice. [PDF]
, 2011 Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition.
Nitschke, Yvonne +3 more
core +1 more source
APOE genetic variants and apoE, miR-107 and miR-650 levels in Alzheimer’s disease
Folia Neuropathologica, 2019 Alzheimer’s disease (AD) is a progressive neurodegenerative dementia in adults. Pathogenesis of AD depends on various factors, including APOE genetic variants, apolipoprotein E (apoE) phenotype and oxidative stress, which may promote both DNA and RNA ...
Michal Prendecki +7 more
doaj +1 more source
C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro [PDF]
, 2015 Subjects carrying the T2238C ANP gene variant have a higher risk to suffer a stroke or myocardial infarction. The mechanisms through which T2238C/αANP exerts detrimental vascular effects need to be fully clarified.
Bianchi, Franca +9 more
core +1 more source
Modulation of apoprotein E secretion in response to receptor-mediated endocytosis in resident and inflammatory macrophages. [PDF]
, 1984 We have determined the effect of various endocytic ligands on the secretion of ApoE by macrophages. ApoE was a major secreted protein of resident macrophages, but BCG-activated macrophages secreted little ApoE and periodate-elicited macrophages secreted ...
Takemura, R, Werb, Z
core +2 more sources
Influence of APOE and RNF219 on Behavioral and Cognitive Features of Female Patients Affected by Mild Cognitive Impairment or Alzheimer's Disease. [PDF]
, 2018 The risk for Alzheimer's disease (AD) is associated with the presence of the ?4 allele of Apolipoprotein E (APOE) gene and, recently, with a novel genetic variant of the RNF219 gene.
Assogna, Francesca +14 more
core +4 more sources
Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation. [PDF]
, 2018 Apolipoprotein (apo) E stands out among plasma apolipoproteins through its unprecedented ability to protect against atherosclerosis. Although best recognized for its ability to mediate plasma lipoprotein clearance in the liver and protect against ...
Hasty +6 more
core +2 more sources
Interactive Effects of Physical Activity and APOE-ε4 On White Matter Tract Diffusivity in Healthy Elders [PDF]
, 2016 Older adult apolipoprotein-E epsilon 4 (APOE-ε4) allele carriers vary considerably in the expression of clinical symptoms of Alzheimer\u27s disease (AD), suggesting that lifestyle or other factors may offer protection from AD-related neurodegeneration ...
Durgerian, Sally +7 more
core +2 more sources
APOE4 Status and cognitive function in middle-aged and elderly people
Balkan Journal of Medical Genetics, 2023 APOE is one of the prominent genes involved in the increased risk of developing Alzheimer’s disease, but its effect on cognition in patients who are not yet diagnosed with dementia or mild cognitive impairment is relatively understudied.
Pavel N.A. +4 more
doaj +1 more source