Results 11 to 20 of about 121,312 (312)

Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping [PDF]

Alzheimer’s Research & Therapy, 2022
Background Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes.
Michael E. Belloy, Sarah J. Eger, Yann Le Guen, Vincent Damotte, Shahzad Ahmad, M. Arfan Ikram, Alfredo Ramirez, Anthoula C. Tsolaki, Giacomina Rossi, Iris E. Jansen, Itziar de Rojas, Kayenat Parveen, Kristel Sleegers, Martin Ingelsson, Mikko Hiltunen, Najaf Amin, Ole Andreassen, Pascual Sánchez-Juan, Patrick Kehoe, Philippe Amouyel, Rebecca Sims, Ruth Frikke-Schmidt, Wiesje M. van der Flier, Jean-Charles Lambert, for the European Alzheimer & Dementia BioBank (EADB), Zihuai He, Summer S. Han, Valerio Napolioni, Michael D. Greicius   +28 more
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Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice. [PDF]

PLoS ONE, 2012
Apolipoprotein (apo) E is best known for its ability to lower plasma cholesterol and protect against atherosclerosis. Although the liver is the major source of plasma apoE, extra-hepatic sources of apoE, including from macrophages, account for up to 10 ...
Nathalie Gaudreault, Nikit Kumar, Victor R Olivas, Delphine Eberlé, Joseph H Rapp, Robert L Raffai   +5 more
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ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition. [PDF]

, 2021
Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's.

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Regional differences in effects of APOE epsilon4 on cognitive impairment in non-demented subjects [PDF]

, 2011
Item does not contain fulltextBACKGROUND: The APOE epsilon4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon4 is common in non-demented subjects with cognitive impairment.
Tsolaki, M, M. Tsolaki, L. Spiru, Spiru, L., Scheltens, P., Verhey, F. R. J., Ewers, M, B. Vellas, R.W. Jones, Elias-Sonnenschein, LS, L. Frölich, Wilcock, G, Kehoe, P. G., Almkvist, O, Kehoe, P.G., Froelich, Lutz, Nobili, F, Olde Rikkert, M., Hampel, H, Verhey, F.R.J., M. Olde Rikkert, P.G. Kehoe, L. Minthon, Frisoni, GB, Elias-Sonnenschein, L.S., Lund University., Frisoni, G. B., P. Scheltens, Wahlund, L. -O., Jones, RW, Frölich, L, Spiru, L, M. Ewers, Wilcock, G., F.R.J. Verhey, Norberg, J., Froelich, L., Schelthens, P, J. Norberg, Vellas, B, Almkvist, Ove, Riqaud, AS, Almkvist, Ove,, G. Wilcock, Frolich, L., Hampel, H., L.-O. Wahlund, Lenoir, H., Norberg, Joakim,, H. Hampel, Minthon, Lennart,, L.S. Elias-Sonnenschein, Jones, R.W., O. Almkvist, F. Nobili, Soininen, H., Graff, C., Norberg, J, Rikkert, M. Olde, Olde Rikkert, M, G.B. Frisoni, NOBILI, FLAVIO MARIANO, Kehoe, PG, Vellas, B., Minthon, Lennart, Frisoni, Giovanni B., Ewers, M., Jones, R. W., Minthon, L, Frisoni, G.B., Minthon, L., Jones, Roy W., Rigaud, A. -S, Wahlund, L.O., Rigaud, A.S., Graff, Caroline, Rigaud, A. S., Visser, P.J., Lenoir, H, Visser, PJ, Wahlund, Lars-Olof, Rigaud, AS, P.J. Visser, H. Lenoir, Almkvist, O., Nobili, F., Graff, C, Frölich, Lutz, Visser, P. J., Tsolaki, M., Elias-Sonnenschein, L. S., Wahlund, L. -O, C. Graff, Wahlund, L. O., Wahlund, LO, Verhey, FR, Scheltens, P, A.-S. Rigaud, Rikkert, Marcel Olde, Soininen, H, Rigaud, A. -S., Elias Sonnenschein, L. S., H. Soininen   +102 more
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A PANEL OF GENETIC MARKERS FOR ANALYZING THE RISK OF LONG-TERM ADVERSE PROGNOSIS OF CARDIOVASCULAR DISEASES

Атеросклероз, 2018
Aim: to form a panel of genetic markers for analyzing the risk of long-term adverse prognosis of cardiovascular diseases in Russia population. Material and methods.
E. V. Shakhtshneider, P. S. Orlov, L. V. Shcherbakova, D. E. Ivanoshchuk, S. K. Malyutina, V. N. Maksimov, V. V. Gafarov, M. I. Voevoda   +7 more
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RNA-Seq Mouse Brain Regions Expression Data Analysis: Focus on ApoE Functional Network

Journal of Integrative Bioinformatics, 2017
ApoE expression status was proved to be a highly specific marker of energy metabolism rate in the brain. Along with its neighbor, Translocase of Outer Mitochondrial Membrane 40 kDa (TOMM40) which is involved in mitochondrial metabolism, the corresponding
Babenko Vladimir N., Smagin Dmitry A., Kudryavtseva Natalia N.   +2 more
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Microbiota and Alzheimer's disease: Toward new clinical approaches [PDF]

Medicinski Podmladak
Alzheimer’s disease (AD) is now viewed as a systemic disorder in which genetics, the gut microbiome and immune dysregulation converge to accelerate amyloid-β (Aβ) and tau pathology. Genetic studies have identified 70 risk loci. The strongest AD risk loci
Đokić Jelena, Dinić Miroslav
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APOE genotype and entorhinal cortex volume in non-demented community-dwelling adults in midlife and early old age [PDF]

, 2012
Copyright © 2012 IOS PressThis article has been made available through the Brunel Open Access Publishing Fund.The apolipoprotein E (APOE) ε4 allele is a risk factor for the neuropathological decline accompanying Alzheimer's disease (AD) while, conversely,
Bunce, David, Perminder Sachdev, Cherbuin, N, Anstey, KJ, David Bunce, Kaarin J. Anstey, Bunce, D, Prapti Gautam, Simon Easteal, Gautam, P, Easteal, S, Cherbuin, Nicolas, Anstey, Kaarin, Gautam, Prapti, Sachdev, Perminder Singh, Nicolas Cherbuin, Sachdev, P, Easteal, Simon   +17 more
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APOE4 Status and cognitive function in middle-aged and elderly people

Balkan Journal of Medical Genetics, 2023
APOE is one of the prominent genes involved in the increased risk of developing Alzheimer’s disease, but its effect on cognition in patients who are not yet diagnosed with dementia or mild cognitive impairment is relatively understudied.
Pavel N.A., Paun M.R., Matei P.V., Dutu I., Tudose C.   +4 more
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ApoE-modified liposomes encapsulating resveratrol and salidroside alleviate manifestations of Alzheimer’s disease in APP/PS-1 mice

, 2023
Alzheimer’s disease (AD) is a neurodegenerative disease that is associated with aging and is influenced by both genetic and environmental factors. Several studies and clinical trials have demonstrated that resveratrol (Res) and salidroside (Sal) are not ...
Xiu-Ying Li (16911670), Liang Kong (154890), Yang Yu (4292), Mu-Han Chen (16911661), Juan Zang (16911667), Xue-Tao Li (4806609), Xin-Ze Liu (12644240), Lu Zhang (50563), Yang Liu (4829), Xiu-Wu Qu (16911664), Rui-Bo Guo (12644237)   +10 more
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