Results 201 to 210 of about 174,900 (290)

Blood PCSK9 Impacts Alzheimer's Disease Risk in an <i>APOE</i> Genotype-Dependent Manner: A Prospective Cohort Study. [PDF]

Health Sci Rep
Tao Q, Ang TFA, Huang J, Itchapurapu IS, Mez J, Alosco M, Au R, Farrer LA, Zhang X, Qiu WQ, Alzheimer's Disease Neuroimaging Initiative.   +10 more
europepmc   +1 more source

'Sleep is overrated'

, 2009
Charlotte Hagenaar (23) is tweedejaars student bestuurskunde en dit jaar secretaris van studentenvereniging SIB (Studentenvereniging voor Internationale Betrekkingen). Ze probeert dit zo goed mogelijk te combineren met haar studie. Bestuurskundige Berichten liet Charlotte een week lang een dagboek bijhouden over haar studie en andere bezigheden.
openaire   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, EarlyView.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

Advances in hiPSC-Derived Brain Organoids as a Model to Study Neuroinflammation in Alzheimer's Disease. [PDF]

J Neurochem
Maciel EMA, Silva NC, Santos LGP, Ribeiro FM.   +3 more
europepmc   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Macrophage-derived galectin-3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF-κB/NLRP3 during atherosclerosis. [PDF]

Clin Transl Med
Yuan Z, Li H, Ruan BX, Huang H, Li Y, Wang J.   +5 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

APOE ε4 and Accelerated Cognitive Decline Among Cognitively Healthy Middle-Aged and Older Adults.

JAMA Netw Open
Chung YE, Chung RH, Hsu CC, Liu YL, Lai RH, Hung WJ, Wu RC, Jiang YJ, Chuang SY, Tsai SF, Kuo CC, Hsiung CA, Chen WJ.   +12 more
europepmc   +1 more source

Puerarin alleviates diabetic atherosclerosis through controlling the follistatin-like 1 related inflammation. [PDF]

Coron Artery Dis
Chen J, Hu Z, Fang M, Hu X, Pan X, Ni X.
europepmc   +1 more source