Results 151 to 160 of about 132,444 (256)

Blood Biomarkers of Alzheimer's Disease and Patterns of Structural Brain Changes in the Community

Annals of Neurology, EarlyView.
Objective We aimed to investigate the associations between Alzheimer's disease (AD)‐related blood biomarkers and changes in brain volumes and cerebrovascular burden in community‐dwelling older adults. Methods We included 361 dementia‐free participants with a Mini‐Mental State Examination (MMSE) score ≥ 27 and without prior cerebrovascular events from a
Martina Valletta, Davide Liborio Vetrano, Erika J. Laukka, Grégoria Kalpouzos, Javier Oltra, Debora Rizzuto, Marco Canevelli, Claudia Fredolini, Chengxuan Qiu, Bengt Winblad, Laura Fratiglioni, Giulia Grande   +11 more
wiley   +1 more source

Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling

, 2017
The hepatic anti-inflammatory potential of hexane extracts of Dioscorea batatas Decne edible part(EDH-1e) and bark(EDH-2b) were investigated in Western-type diet-fed apolipoprotein E null [ApoE(-/-)] mice and HepG2 cells. EDH-1e and EDH-2b suppressed the 
표석능, 강세찬, 손은수, 이성률, 구현정, 손은화, 장광진   +6 more
core  

An Investigation of Sleep Macro‐ and Microarchitecture by APOE Genotype

Annals of Neurology, EarlyView.
Objectives Apolipoprotein E ε4 (APOE ε4), a robust genetic risk factor for Alzheimer's disease (AD) is associated with functional connectivity deficits and amyloid pathology in brain regions involved in sleep regulation. Thus, alterations in sleep architecture may be one pathway through which ε4 contributes to Alzheimer's disease vulnerability. However,
Gawon Cho, Anne Chen, Eunyoung Choi, Orfeu M. Buxton, Daniel Kay, Adam Mecca, Brienne Miner   +6 more
wiley   +1 more source

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

International audienceAlzheimer’s disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles.
Holtzman, David, Gratuze, Maud, Bordier, Chiara, Ulrich, Jason D, Lennol, Matthew Paul, Holtzman, David M, Kamelher, Léana, Ulrich, Jason   +7 more
core   +1 more source

ApolipoproteinE⁺ Kupffer cells maintain immune homeostasis following liver transplantation by inducing CD8⁺ T cell exhaustion. [PDF]

iScience
Jia Z, Li X, Wang X, Zhou X, Cai H, Jiang P, Ding R, Liu H, Wang Y, Li S, Cai J.   +10 more
europepmc   +1 more source

Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers

, 2016
The presence of the e4 allele of the apolipoprotein E (APOE) gene is the best-known genetic risk factor for Alzheimer's disease. In this study, we investigated the link between functional and behavioural differences and regional brain volume and cortical
Sarah King (4460617), Jennifer Rusted (4460485), Simon L Evans (16039634), Naji Tabet (4461808), Nicholas Dowell (4462081), Paul S Tofts (16048253)   +5 more
core  

Genetic Resilience and Resistance in Alzheimer's Disease Diagnosis and Pathology

Annals of Neurology, EarlyView.
Objective Some individuals avoid Alzheimer's disease (AD) pathology as they age, or retain cognition despite substantial pathology, suggesting mechanisms of resistance or resilience to neurodegeneration. Educational attainment (EA) is associated with reduced risk of cognitive decline, although the underlying mechanisms remain unclear.
Ganna Leonenko, Kalliopi Mavromati, Lynne Hughes, Jonas S. Sundarakumar, Keeley Brookes, Kevin Morgan, Terry Quinn, Valentina Escott‐Price, the Alzheimer's Disease Neuroimaging Initiative   +8 more
wiley   +1 more source

Hepatocyte-Specific <i>Nrf2</i> Deficiency Alters Cholesterol Metabolism, Leading to Mitigated Atherosclerosis in <i>ApoE</i>-Knockout Mice. [PDF]

Antioxidants (Basel)
Jiao J, Xu N, Hong Z, Chang L, Huang D, Yu Y, Wang Z, Li Y, Yu J, Guo J, Wang Y, Kuang L, Wang Y, Yang B, Zhao R, Hou Y, Wang H, Zhang Q, Xu P, Xu Y, Pi J, Fu J.   +21 more
europepmc   +1 more source

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source

Link Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms

Ayse Dondu,1 Metin Caliskan,2 Seda Orenay-Boyacioglu3 1Department of Psychiatry, Aydın Goverment Hospital, Aydin, 09010, Turkey; 2Department of Medical Biology, Faculty of Medicine, Usak University, Usak, 64000, Turkey; 3Department of Medical ...
Orenay-Boyacioglu S, Dondu A, Caliskan M
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