Results 191 to 200 of about 132,444 (256)

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Na/K-ATPase Signaling in Adipocytes Promotes Atherosclerosis. [PDF]

Arterioscler Thromb Vasc Biol
De Souza Goncalves B, Wang Y, Pillai SS, Luu QQ, Triniac H, Lakhani HV, Chaudhry MA, Zheng Z, Shapiro JI, Silverstein RL, Sodhi K, Chen Y.   +11 more
europepmc   +1 more source

Association Between Plasma Phosphorylated Tau‐217 and Cognition in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Alzheimer's disease (AD) co‐pathology contributes to dementia in PD, but its role in earlier cognitive impairment remains uncertain. Objective To determine if p‐tau217, a biomarker of early AD, is associated with cognitive impairment in PD.
Trycia Kouchache, Tevy Chan, Sophie Sun, Lang Liu, Aline Delva, Ziv Gan‐Or, Pedro Rosa‐Neto, Jean‐François Gagnon, Alain Dagher, Ronald B. Postuma, Madeleine Sharp   +10 more
wiley   +1 more source

Genetic susceptibility of Alzheimer's disease associated with APOE polymorphism: systematic review and bibliometric study. [PDF]

J Genet Eng Biotechnol
Amukti DP, Kusumawardani N, Pratami RI, Purwanto BD, Rukhama RA, Akbar I, Sarwadhamana RJ, Aditya RA, Yuliani S.   +8 more
europepmc   +1 more source

Joint Risk Factor Combinations with Additive Interaction Increase the Risk of Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Combined effects of multiple risk factors on incident late‐onset Parkinson's disease (PD; LOPD) remain poorly characterized. Objective The objective of this study was to quantify the impact of joint risk exposures and estimate the contribution of potentially modifiable factors to incident LOPD risk.
Andrea Quattrone, Basilio Vescio, Fulvia Arcuri, Giuseppe Chiarella, Jolanda Buonocore, Aldo Quattrone   +5 more
wiley   +1 more source

Inactivation of interleukin-15 reduces spontaneous atherosclerosis in <i>apolipoprotein E</i>-deficient mice. [PDF]

Front Physiol
Dadoo O, Sokeechand BSH, Lee A, Fuller MT, Wang YCD, MacDonald ME, Batenburg NL, Igdoura SA, Richards CD, Ashkar AA, Trigatti BL.   +10 more
europepmc   +1 more source

Lewy Body Disease Across Aging: Clinical and Neuropathological Correlates in a Population Brain Bank

Movement Disorders, EarlyView.
Abstract Background Lewy body disease (LBD) is defined by neuronal α‐synuclein pathology, but how Braak‐staged LBD relates to mixed neuropathology and clinical manifestations within a single population‐based cohort remains incompletely characterized. This is especially relevant in cohorts enriched for younger individuals, which may better inform real ...
Vitor Ribeiro Paes, Felipe Luiz Pereira, Caroline Matos Silva, Filipe Oto Cunha de Moraes, Inês Liguori Padrão, Alberto Fernando Oliveira Justo, Roberta Diehl Rodriguez, Michel Satya Naslavsky, Renata Elaine Paraizo Leite, Carlos Augusto Gonçalves Pasqualucci, Mayana Zatz, Eduardo Ferriolli, Claudia Kimie Suemoto, Lea Tenenholz Grinberg   +13 more
wiley   +1 more source

Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk. [PDF]

Ann Neurol
Peña-Tauber A, Hernández Arriaza R, Reil D, Muntaner M, Park J, Grenier-Boley B, Hulsman M, Amouyel P, Bellenguez C, Charbonnier C, Deleuze JF, Dols-Icardo O, Hardy J, Holstege H, Nicolas G, Mead S, Wagner M, Ramirez A, Sims R, van Swieten J, Willams J, Lambert JC, Khosla C, Le Guen Y, Greicius MD.   +24 more
europepmc   +1 more source

Protosappanin A Alleviates Atherosclerosis by Regulating the MDM2/GPX4 Axis‐Mediated Endothelial Ferroptosis

Phytotherapy Research, EarlyView.
PTA alleviates atherosclerosis by regulating the MDM2/GPX4 axis‐mediated endothelial ferroptosis. ABSTRACT Endothelial ferroptosis is a crucial pathogenic driver of atherosclerosis (AS) progression. Protosappanin A (PTA), a bioactive compound from Caesalpinia sappan L., protects cardiovascular vessels by regulating ferroptosis.
Jiamei Fu, Lin Zhu, Wenwei Yang, Mengnan Li, Zhixin Wu, Shude Sun, Yabin Zhou   +6 more
wiley   +1 more source

A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations. [PDF]

Nat Genet
Kurniansyah N, Tasaki S, Rehman H, Zhu C, Farrell J, Sherva R, Hauger R, Merritt VC, Panizzon M, Zhang R, Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Mukherjee S, Trittschuh EH, Lee AJ, Brickman AM, Cruchaga C, Risacher S, Greve DN, Crane P, Martin E, Bush WS, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang LS, Schellenberg GD, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X, Farrer LA.   +41 more
europepmc   +1 more source