Results 221 to 230 of about 132,444 (256)

Heparanase gene deficiency suppresses atherosclerosis progression and enhances plaque stability in apolipoprotein E gene knockout mice with diabetes. [PDF]

Clin Sci (Lond)
Nguyen TK, Baxter AA, Bourchier C, Phan TK, Chan E, Poon IKH, Thomas SR, Hulett MD.   +7 more
europepmc   +1 more source

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source

Amyloid-<i>β</i> modulates APOE ε4 effects on cognition but not on targeted structural or functional connectivity measures over 2 years in pre-dementia adults. [PDF]

Front Aging Neurosci
Wei H, Zhang T, Liang Z, Li M, Kong M, Ba M.   +5 more
europepmc   +1 more source

β-glucan elicits APOE-dependent peripheral trained immunity to suppress hepatocellular carcinoma. [PDF]

J Immunother Cancer
Jiang N, Wu T, Yang R, He G, Ding B, Zhu C, Liu H, Xu X, Yang B, Xie H, Zheng S, Tong R, Wu J.   +12 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Lower cardiac output is a risk factor for faster cerebral atrophy over a 11-year follow-up period in APOE-ε4 carriers. [PDF]

Alzheimers Dement
Moore EE, Zhang P, Khan OA, Liu D, Gupta DK, Pechman KR, Gifford KA, Landman BA, Hohman TJ, Jefferson AL.   +9 more
europepmc   +1 more source

From regulatory approval to clinical practice: real-world eligibility for anti-amyloid monoclonal antibodies in an Italian dementia-care network. [PDF]

J Prev Alzheimers Dis
Zamboni G, Tondelli M, Vinceti G, Gallingani C, Bercini Z, Barbieri A, Carbone C, Iacovino N, Cossutti S, Ballotta D, Salemme S, Chiari A.   +11 more
europepmc   +1 more source

The role of polygenic risk in Alzheimer's disease prediction for African Americans. [PDF]

Alzheimers Dement
Hutten CG, Beck T, Evans D, Rajan KB.
europepmc   +1 more source

Ventral hippocampal-postcentral gyrus functional connectivity mediates the association of APOE ε4 gene dose, depressive symptoms, and cognitive function in mild cognitive impairment with subsyndromal depression. [PDF]

Front Aging Neurosci
Du Y, Li S, Wen Y, Du B, Jiang G.
europepmc   +1 more source

Apolipoprotein E2/2 (APOE2/2) Genotype Is Associated With Reduced Choroidal Thickness. [PDF]

Invest Ophthalmol Vis Sci
Borchert GA, Ferreira LAF, Raji S, Yu J, Segovia M, MacLaren RE, Downes SM, Cehajic-Kapetanovic J, Xue K, De Silva SR.   +9 more
europepmc   +1 more source