Results 211 to 220 of about 121,312 (312)

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

Tahsin Yücel'in 'Yalan' ve Gustave Flaubert'in 'Bouvard ile Pecuchet' adlı romanlarında entelektüel söylem ve 'entelektüel'in sorunsallaştırılması

, 2008
Kültürlerarası iletişim çalışmalarının giderek arttığı bir dönemde, biri Doğuya, diğeri Batıya ait iki yazarı ve yapıtlarını yüzleştirerek, be/il bir olgu çerçevesinde temel benzerlik ve farkl lık/arı ortaya koymak bu çal şmanın temel amacını oluşturmaktadır.
openaire   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

The physiological effects of APOE genotype in healthy young/middle-aged individuals. [PDF]

Biol Rev Camb Philos Soc
de Leeuw SM, Emrani S, Putter J, Nuriel T.   +3 more
europepmc   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Redox status of apolipoprotein E in cerebrospinal fluid: a mechanistically informative biomarker for central nervous system disorders. [PDF]

Biosci Rep
Uematsu Y, Iinuma W, Shimizu R, Matsuura H, Yoshinaga T, Yazaki M, Yamauchi K.   +6 more
europepmc   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease. [PDF]

EBioMedicine
O'Brien EK, Cox T, Fernandez S, Bourgeat P, Porter T, Goudey B, Doecke JD, Masters CL, Fripp J, Nho K, Villemagne VL, Cruchaga C, Rowe CC, Saykin AJ, Doré V, Laws SM.   +15 more
europepmc   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Context-Dependent Effects of Apolipoprotein A2 on Lipid Metabolism and Atherogenesis. [PDF]

FASEB J
Zvintzou E, Fenyo IM, Ionita R, Kakafoni G, Dumitrescu M, Alemi M, Daraban BS, Marinos K, Gafencu AV, Kypreos KE.   +9 more
europepmc   +1 more source