Results 121 to 130 of about 131,925 (308)

Anatomically-distinct genetic associations of APOE e{open}4 allele load with regional cortical atrophy in Alzheimer's disease

, 2009
APOE ɛ4 is the best-established genetic risk factor for sporadic Alzheimer's disease (AD). However, while homozygotes show greater disease susceptibility and earlier age of onset than heterozygotes, they may not show faster rates of clinical progression.
Williams, J., Nichols, T., Rao, A., Gibson, R.A., Whitcher, B., Borrie, M., Matthews, P.M., Filippini, N., Guzman, D., Loy-English, I., Wetten, S., Kertesz, A.   +11 more
core   +1 more source

Summary statistics from epigenome-wide association studies and meta-analysis comparing APOE ε4 and APOE ε2 allele carriers in Generation Scotland

, 2020
These datasets contain full summary statistics for epigenome-wide association studies (EWASs) carried out using two methylation samples from the Generation Scotland: Scottish Family Health Study to investigate associations between blood-based DNA ...
Evans, Kathryn, Bermingham, Mairead, Amador, Carmen, Walker, Rosie, Campbell, Archie, Haley, Chris, Zeng, Yanni, Bretherick, Andrew, Marioni, Riccardo, Vaher, Kadi, McIntosh, Andrew, Rawlik, Konrad, Porteous, David, Morris, Stewart, Hayward, Caroline   +14 more
core   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Apolipoprotein E: A Potential Prognostic and Diagnostic Biomarker for Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma
Yuxia Li, Ruijiao Lu, Xieyidai Abuduhailili, Yangchun Feng Department of Clinical Laboratory Center, Cancer Hospital Affiliated to Xinjiang Medical University, Urumqi, 830000, People’s Republic of ChinaCorrespondence: Yangchun Feng, Email paopao1987123 ...
Li Y, Lu R, Abuduhailili X, Feng Y
doaj  

Statükoculuk'tan ''Çok Yönlü Dış Politika'ya'': ''Komşularla Sıfır Sorun'' değerlendirmesi

, 2012
Türk dış politikası cumhuriyetin kurulmasından itibaren genel olarak üç temel politika üzerine kurulmuştur. Bunlar `Statükocu', `Batıcı' ve `Güvenlikçi' yaklaşımlar olmuştur. Cumhuriyetin kuruluş aşamasında hem Türkiye'nin içinde bulunduğu koşullar hem de dünya konjonktürü bu politikaların yürütülmesinde belirleyici olmuştur ...
openaire   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

APOE suppresses osteosarcoma by modulating ferroptosis through the mTOR/Stat3 signaling pathway

Archives of Medical Science
Introduction Osteosarcoma (OS) is a highly malignant bone tumor with limited treatment options. The role of apolipoprotein E (APOE) in OS remains unclear.
Xiangyang Cheng, Chong Bian, Yiming Zhang, Huijie Gu, Guangnan Chen, Liang Wu   +5 more
doaj   +1 more source

'Atrocity Suppression': an alternative to 'Humanitarian Intervention'

, 2021
The concept of humanitarian intervention has been around for centuries but came to particular prominence in the mid-1990s on foot of Genocides in Rwanda and at Srebrenica, Bosnia. The shocking brutality and scale of these events and the steadfast failure of the international community to defend the victims propelled the issue of humanitarian ...
openaire   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source