Results 101 to 110 of about 135,666 (308)

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar-Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps. [PDF]

Adv Sci (Weinh)
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Zhu X, Chen Y, Meng W, Xu B, Mou J, Liu X, Wang M, Gu Q, Sun Q, Li M, Zhao C, Zeng M, Lv Y, Yi B, Qu S, Bai X, Li J, Luo X, Hu S, Yu B, Jia H.   +20 more
europepmc   +2 more sources

ApoE Allele Frequencies and Regional Richness of Intracellular Pathogens and Extracellular Pathogens

, 2020
Research into the genetic factors that contribute to human health and longevity has found that individual's apolipoprotein E (APOE) genotype is linked to their risk for developing Alzheimer's disease and cardiovascular diseases.
Mueller, Alison
core  

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Introducing Human APOE into Aβ Transgenic Mouse Models [PDF]

, 2011
Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer’s disease risk.
Katherine L. Youmans (7946321), Chunjiang Yu (707892), Mary Jo LaDu (7935848), Leon M. Tai (7946312), Lisa Jungbauer (7946315)   +4 more
core   +2 more sources

Ox-ApoE binds weakly to emulsion particles.

, 2013
A. Ox-ApoE binding with triglyceride-PC emulsion particles. Native and ox-ApoE were incubated with triglyceride-PC emulsion particles at room temperature for 1 hr with gentle shaking.
Youfeng Yang (382219), Ling Tian (107492), Guangjie Cheng (382221), W. Timothy Garvey (113627), Zehong Cao (382220)   +4 more
core   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

APOE suppresses osteosarcoma by modulating ferroptosis through the mTOR/Stat3 signaling pathway

Archives of Medical Science
Introduction Osteosarcoma (OS) is a highly malignant bone tumor with limited treatment options. The role of apolipoprotein E (APOE) in OS remains unclear.
Xiangyang Cheng, Chong Bian, Yiming Zhang, Huijie Gu, Guangnan Chen, Liang Wu   +5 more
doaj   +1 more source

Genetic Effects of NDUFAF6 rs6982393 and APOE on Alzheimer’s Disease in Chinese Rural Elderly: A Cross-Sectional Population-Based Study

Clinical Interventions in Aging, 2022
Yingzhe Cheng,1 Yuanjing Li,2 Xiaoyan Liang,3,4 Pin Wang,3 Wenxin Fa,1 Cuicui Liu,1,3,4 Yongxiang Wang,1,3,4 Keke Liu,5 Nan Wang,3,4 Yifeng Du1,3,4 1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University ...
Cheng Y, Li Y, Liang X, Wang P, Fa W, Liu C, Wang Y, Liu K, Wang N, Du Y   +9 more
doaj  

Lesional macrophage-derived apoE.

, 2013
Immunofluorescent images of Apoeh/hLysM-Cre (A,C) and Apoeh/h mice (B,D; scale bar = 250 µm) aortic roots; anti-Mac-2 (green), and apoE (red). Quantification of lesion area (E), macrophage positive and % of area (F–G); n = 7.
Nathalie Gaudreault (221057), Robert L. Raffai (173840), Nikit Kumar (323362), Delphine Eberlé (323364), Victor R. Olivas (323363), Joseph H. Rapp (323365)   +5 more
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source