Results 21 to 30 of about 135,666 (308)

Molecular recognition of the interaction between ApoE and the TREM2 protein

Translational Neuroscience, 2022
Alzheimer’s disease (AD) is the most common type of dementia. The ε4 allele of the apolipoprotein E (ApoE) gene is the strongest known genetic risk factor for late-onset AD.
Mai Zhenhua, Wei Wenyan, Yu Haibin, Chen Yongze, Wang Yongxiang, Ding Yuanlin   +5 more
doaj   +1 more source

Utilization of cognitive support in episodic free recall as a function of apolipoprotein E and vitamin B12 or folate among adults aged 75 years and older [PDF]

, 2004
Apolipoprotein E (APOE), vitamin B12, and folate were examined in relation to free recall among 167 community-based older adults. Cognitive support at encoding and retrieval was also taken into account.
Kivipelto, M, Wahlin, A, Bunce, D
core   +3 more sources

Affective symptoms across the life course and resilience in cognitive function

Annals of Human Biology, 2020
Background: Little is known about what factors can modify the relationship between affective symptoms and cognitive function across the life course.
Georgia Bell, Amber John, Darya Gaysina
doaj   +1 more source

A PANEL OF GENETIC MARKERS FOR ANALYZING THE RISK OF LONG-TERM ADVERSE PROGNOSIS OF CARDIOVASCULAR DISEASES

Атеросклероз, 2018
Aim: to form a panel of genetic markers for analyzing the risk of long-term adverse prognosis of cardiovascular diseases in Russia population. Material and methods.
E. V. Shakhtshneider, P. S. Orlov, L. V. Shcherbakova, D. E. Ivanoshchuk, S. K. Malyutina, V. N. Maksimov, V. V. Gafarov, M. I. Voevoda   +7 more
doaj   +1 more source

Regional differences in effects of APOE epsilon4 on cognitive impairment in non-demented subjects [PDF]

, 2011
Item does not contain fulltextBACKGROUND: The APOE epsilon4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon4 is common in non-demented subjects with cognitive impairment.
Tsolaki, M, M. Tsolaki, L. Spiru, Spiru, L., Scheltens, P., Verhey, F. R. J., Ewers, M, B. Vellas, R.W. Jones, Elias-Sonnenschein, LS, L. Frölich, Wilcock, G, Kehoe, P. G., Almkvist, O, Kehoe, P.G., Froelich, Lutz, Nobili, F, Olde Rikkert, M., Hampel, H, Verhey, F.R.J., M. Olde Rikkert, P.G. Kehoe, L. Minthon, Frisoni, GB, Elias-Sonnenschein, L.S., Lund University., Frisoni, G. B., P. Scheltens, Wahlund, L. -O., Jones, RW, Spiru, L, M. Ewers, Wilcock, G., F.R.J. Verhey, Norberg, J., Froelich, L., Schelthens, P, J. Norberg, Vellas, B, Almkvist, Ove, Riqaud, AS, Almkvist, Ove,, G. Wilcock, Frolich, L., Hampel, H., L.-O. Wahlund, Lenoir, H., Norberg, Joakim,, H. Hampel, Minthon, Lennart,, L.S. Elias-Sonnenschein, Jones, R.W., O. Almkvist, F. Nobili, Soininen, H., Graff, C., Norberg, J, Rikkert, M. Olde, Olde Rikkert, M, G.B. Frisoni, NOBILI, FLAVIO MARIANO, Kehoe, PG, Vellas, B., Minthon, Lennart, Frisoni, Giovanni B., Ewers, M., Jones, R. W., Minthon, L, Frisoni, G.B., Minthon, L., Jones, Roy W., Rigaud, A. -S, Wahlund, L.O., Rigaud, A.S., Graff, Caroline, Rigaud, A. S., Visser, P.J., Lenoir, H, Visser, PJ, Wahlund, Lars-Olof, Rigaud, AS, P.J. Visser, H. Lenoir, Almkvist, O., Nobili, F., Graff, C, Frölich, Lutz, Visser, P. J., Tsolaki, M., Elias-Sonnenschein, L. S., Wahlund, L. -O, C. Graff, Wahlund, L. O., Wahlund, LO, Verhey, FR, Scheltens, P, A.-S. Rigaud, Rikkert, Marcel Olde, Soininen, H, Rigaud, A. -S., Elias Sonnenschein, L. S., H. Soininen, Graff, C,, Froelich, L, Almkvist, O,, Frolich, L   +105 more
core   +1 more source

RNA-Seq Mouse Brain Regions Expression Data Analysis: Focus on ApoE Functional Network

Journal of Integrative Bioinformatics, 2017
ApoE expression status was proved to be a highly specific marker of energy metabolism rate in the brain. Along with its neighbor, Translocase of Outer Mitochondrial Membrane 40 kDa (TOMM40) which is involved in mitochondrial metabolism, the corresponding
Babenko Vladimir N., Smagin Dmitry A., Kudryavtseva Natalia N.   +2 more
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Microbiota and Alzheimer's disease: Toward new clinical approaches [PDF]

Medicinski Podmladak
Alzheimer’s disease (AD) is now viewed as a systemic disorder in which genetics, the gut microbiome and immune dysregulation converge to accelerate amyloid-β (Aβ) and tau pathology. Genetic studies have identified 70 risk loci. The strongest AD risk loci
Đokić Jelena, Dinić Miroslav
doaj   +1 more source

The role of the KIBRA and APOE genes in developing spatial abilities in humans

Вавиловский журнал генетики и селекции, 2022
In the contemporary high-tech society, spatial abilities predict individual life and professional success, especially in the STEM (Science, Technology, Engineering, and Mathematics) disciplines.
A. V. Kazantseva, R. F. Enikeeva, Yu. D. Davydova, R. N. Mustafin, Z. R. Takhirova, S. B. Malykh, M. M. Lobaskova, T. N. Tikhomirova, E. K. Khusnutdinova   +8 more
doaj   +1 more source

eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. [PDF]

, 2012
All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation ...
Sabine Grüner, Ostermeier Eva, Ostermeier, Eva, Bernhard Nieswandt, Huang Paul L., Angelika Schröttle, Georg Ertl, Ertl, Georg, Ulrich Hoffmann, Peter J Kuhlencordt, Kuhlencordt Peter J., Huang, Paul, Nieswandt Bernhard, Schröttle Angelika, Grüner, Sabine, Huang, Paul L., Paul L Huang, Ponnuswamy, Padmapriya, Schröttle, Angelika, Ertl Georg, Hoffmann Ulrich, Hoffmann, Ulrich, Padmapriya Ponnuswamy, Nieswandt, Bernhard, Grüner Sabine, Ponnuswamy Padmapriya, Kuhlencordt, Peter J., Eva Ostermeier   +27 more
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Features of bone remodeling and osteoreparation processes in modeling femoral fracture in genetically modified mice with impaired enzymatic regulation of steroid hormone metabolism

Research Results in Pharmacology, 2023
Introduction: The aim of this study was to evaluate the processes of bone remodeling and osteoreparation in modeling femoral fracture in mice with zero expression of 11β-HSD2 (11β-HSD2-/-) or both 11β-HSD2 and apolipoprotein e (11β-HSD2-/-/ApoE ...
Mikhail V. Korokin, Oleg S. Gudyrev, Tatiana G. Pokrovskaya, Lyudmila M. Danilenk, Nina I. Zhernakova, Tatyana V. Avtina, Sergey A. Pribylov, Petr R. Lebedev, Alim A. Kochkarov, Elеna V. Kuzubova, Alexandra I. Radchenko, Ivan S. Koklin, Eduard I. Taran   +12 more
doaj   +1 more source