Results 31 to 40 of about 159,989 (316)

Interaction between SNPs in the RXRA and near ANGPTL3 gene region inhibits apoB reduction after statin-fenofibric acid therapy in individuals with mixed dyslipidemia

Journal of Lipid Research, 2012
The mixed dyslipidemia phenotype is characterized by elevated triglycerides (TG), low HDL cholesterol (HDL-C), increased ApoB levels, and premature coronary atherosclerosis.
Li Ma, Christie M. Ballantyne, John W. Belmont, Alon Keinan, Ariel Brautbar   +4 more
doaj   +1 more source

Особенности дислипидемических нарушений у больных с шизофренией при терапии галоперидолом и рисперидоном в зависимости от носительства некоторых генетических полиморфизмов

Современная терапия психических расстройств, 2019
Цель исследования – определение роли полиморфизма некоторых генов в развитии дислипидемических нарушений при психофармакотерапии у больных параноидной шизофренией.
Штань, М.С., Озорнин, А.С., Говорин, Н.В.   +2 more
doaj   +1 more source

Age-related behavioural abnormalities in C57BL/6.KOR–Apoe shl mice

Translational Neuroscience
Spontaneously hyperlipidaemic (Apoeshl) mice were discovered in 1999 as mice lacking apolipoprotein E (ApoE) owing to a mutation in the Apoe gene. However, age-related behavioural changes in commercially available Apoeshl mice have not yet been clarified.
Ueno Hiroshi, Takahashi Yu, Mori Sachiko, Kitano Eriko, Murakami Shinji, Wani Kenta, Miyazaki Tetsuji, Matsumoto Yosuke, Okamoto Motoi, Ishihara Takeshi   +9 more
doaj   +1 more source

Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis

Journal of Lipid Research, 2011
Expression of apoE in adipocytes has been shown to have an important role in modulating adipocyte triglyceride (TG) metabolism and gene expression that is independent of circulating and extracellular apoE.
Zhi H. Huang, Nobuyo Maeda, Theodore Mazzone   +2 more
doaj   +1 more source

Apolipoprotein[a] is not associated with apolipoprotein B in human liver

Journal of Lipid Research, 1994
The aim of this research was to determine whether apolipoprotein[a] (apo[a]) is linked to apolipoprotein B (apoB) in human liver. Four ELISAs were developed: 1) a competition assay that measures apoB; 2) a competition assay that measures apo[a]; 3) a capture assay based on capture of apo[a] by a polyclonal antibody and detection of co-immobilized apoB ...
J Wilkinson, L H Munro, J A Higgins
openaire   +3 more sources

Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts)

, 2005
Apolipoprotein E (apoE) is a multifunctional circulating 34-kDa protein, whose gene encodes single-nucleotide polymorphisms linked to several neurodegenerative diseases.
Owen, JS, Dickson, J George, Tagalakis, Aristides D, Simons, JP, Owen, James S, Simons, J Paul, Tagalakis, AD, Dickson, JG   +7 more
core   +1 more source

Role of Apolipoprotein D and Its Homologs, in Normal and Pathological Aging, in Drosophila melanogaster [PDF]

, 2009
The free radical theory of aging is probably the most enduring one to date. It stipulates that, in the process of normal cellular function, in particular due to oxygen-based respiration, reactive oxygen species are formed.
Muffat, Julien A.
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content

Journal of Lipid Research, 2015
ApoA5 has a critical role in the regulation of plasma TG concentrations. In order to determine whether ApoA5 also impacts ectopic lipid deposition in liver and skeletal muscle, as well as tissue insulin sensitivity, we treated mice with an antisense ...
João Paulo G. Camporez, Shoichi Kanda, Max C. Petersen, François R. Jornayvaz, Varman T. Samuel, Sanjay Bhanot, Kitt Falk Petersen, Michael J. Jurczak, Gerald I. Shulman   +8 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source