Results 21 to 30 of about 159,989 (316)

PCSK9 loss-of-function variants and Lp(a) phenotypes among black US adults

Journal of Lipid Research, 2019
The pharmacologic inhibition of proprotein convertase subtilisin-kexin type 9 (PCSK9) lowers lipoprotein (a) [Lp(a)] concentrations. However, the impact of genetic PCSK9 loss-of-function variants (LOFVs) on Lp(a) is uncertain.
Matthew T. Mefford, Santica M. Marcovina, Vera Bittner, Mary Cushman, Todd M. Brown, Michael E. Farkouh, Sotirios Tsimikas, Keri L. Monda, J. Antonio G. López, Paul Muntner, Robert S. Rosenson   +10 more
doaj   +1 more source

Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage [PDF]

, 2004
Objectives–To investigate the association between APOE genotype and cognitive and emotional outcome following spontaneous subarachnoid haemorrhage (SAH).Materials and methods–Neuropsychological assessments were conducted with 70 SAH survivors derived ...
Morris, Paul Graham; id_orcid, Nicoll, James A R, Dunn, L.T., Wilson, J T Lindsay, Dunn, Laurence T, Nicoll, J.A., Wilson, J.T., Morris, P.G.   +7 more
core   +1 more source

D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma[S]

Journal of Lipid Research, 2011
Asthma is characterized by oxidative stress and inflammation of the airways. Although proinflammatory lipids are involved in asthma, therapies targeting them remain lacking. Ac-DW F KA F YDKVAEK F KEA F NH2 (4F) is an apolipoprotein (apo)A-I mimetic that
S.D. Nandedkar, D. Weihrauch, H. Xu, Y. Shi, T. Feroah, W. Hutchins, D.A. Rickaby, N. Duzgunes, C.A. Hillery, K.S. Konduri, Jr.K.A. Pritchard   +10 more
doaj   +1 more source

Cellular cholesterol efflux in heterozygotes for Tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size

Journal of Lipid Research, 2000
Tangier disease (TD), caused by mutations in the ATP-binding cassette 1 (ABC-1) gene, is a rare genetic disorder characterized by severe deficiency of high density lipoproteins (HDL) in the plasma, hypercatabolism of HDL, and defective apolipoprotein ...
Margaret E. Brousseau, Gretchen P. Eberhart, Josée Dupuis, Bela F. Asztalos, Allison L. Goldkamp, Ernst J. Schaefer, Mason W. Freeman   +6 more
doaj   +1 more source

Degradation of human apolipoprotein B‐100 by apolipoprotein(a)

FEBS Letters, 1993
Human plasma low density lipoproteine (LDL) contain a very high molecular weight protein termed apoB‐100 (M r = 550,000). In many samples of LDL, minor components designated as apoB‐74 (M r = 407,000) and apoB‐26 (M r = 145,000) are present. It has been shown that they can arise as a result of proteolytic degradation of apoB‐100.
Chulkova, T.M., Tertov, V.V.
openaire   +2 more sources

Dyslipidemia and its relationship with chronic non-communicable diseases (according to the MERIDIAN-RO study)

Медицинский совет, 2015
MERIDIAN-RO, a prospective cohort cross-sectional study with retrospective component, aimed to evaluate the incidence of lipid metabolism disorders in the Ryazan region and their relationship with chronic non-communicable diseases. In 2011, 1,622 people (
E. V. Filippov, Y. A. Balanova
doaj   +1 more source

Multiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene. [PDF]

, 2013
: BACKGROUND: Apolipoprotein B (APOB) is an integral component of the chylomicron and the atherogenic lipoproteins LDL and Lp(a). Exon 26 of the APOB pre-mRNA is unusually long at 7,572 nt and is constitutively spliced.
Srirangalingam, U, Navaratnam, N, Chew, SL, Norman, D, Khoo, B, Akker, SA   +5 more
core   +1 more source

Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E

, 2010
It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors ...
Kirkwood Thomas B. L., Drenos Fotios, Drenos, F, Kirkwood, TBL, Fotios Drenos, Thomas B L Kirkwood   +5 more
core   +1 more source

A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease

Pharmaceutics, 2023
High-density lipoproteins (HDL) are complex endogenous nanoparticles involved in important functions such as reverse cholesterol transport and immunomodulatory activities, ensuring metabolic homeostasis and vascular health. The ability of HDL to interact
Alankrita Rani, Gunther Marsche
doaj   +1 more source

Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene. [PDF]

, 2006
Apolipoprotein AV (ApoAV) gene variant, -1131T>C, is associated with increased triglyceride concentrations in all ethnic groups studied. An MseI based RFLP analysis is the most commonly used method for genotyping this SNP.
Andrew T Hattersley, Venigalla, Prathyusha NS, Kirsten J Ward, Ward Kirsten J, Hattersley, Andrew T, Ward, Kirsten J, Giriraj R Chandak, Ellard Sian, Timothy M Frayling, Prathyusha NS Venigalla, Frayling, Timothy M, Sian Ellard, Chittaranjan S Yajnik, Hattersley Andrew T, Chandak Giriraj R, Frayling Timothy M, Yajnik Chittaranjan S, Chandak, Giriraj R, Venigalla Prathyusha NS, Ellard, Sian, Yajnik, Chittaranjan S   +20 more
core   +1 more source