Results 21 to 30 of about 126,178 (268)

Regulation of apoA-I gene expression

Journal of Lipid Research, 2004
We have previously shown that 17-β-estradiol (E2) and genistein increase the expression of apolipoprotein A-I (apoA-I), the major protein component of HDL, in Hep G2 cells.
Stefania Lamon-Fava, Dale Micherone
doaj   +1 more source

Liver X receptors are regulators of adipocyte gene expression but not differentiation

Journal of Lipid Research, 2004
The liver X receptors α and β (LXRα and LXRβ) have been shown to play important roles in lipid homeostasis in liver and macrophages, however, their function in adipose tissue is not well defined.
Sarah Hummasti, Bryan A. Laffitte, Michael A. Watson, Cristin Galardi, Lily C. Chao, Lakshman Ramamurthy, John T. Moore, Peter Tontonoz   +7 more
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Characterization of Cardiac, Vascular, and Metabolic Changes in Young Childhood Cancer Survivors

Frontiers in Pediatrics, 2021
Background: Childhood cancer survivors (CCS) are at an increased risk for cardiovascular diseases (CVD). It was the primary aim of this study to determine different measures of cardiac, carotid, lipid, and apolipoprotein status in young adult CCS and in ...
Olof Broberg, Olof Broberg, Ingrid Øra, Ingrid Øra, Thomas Wiebe, Constance G. Weismann, Constance G. Weismann, Petru Liuba, Petru Liuba   +8 more
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Apolipoprotein M [PDF]

Lipids in Health and Disease, 2004
AbstractApolipoprotein M (apoM) is a 26-kDa protein that is mainly associated with high-density lipoprotein (HDL) in human plasma, with a small proportion present in triglyceride-rich lipoproteins (TGRLP) and low-density lipoproteins (LDL). Human apoM gene is located in p21.31 on chromosome 6 (chromosome 17, in mouse).
Nilsson-Ehle Peter, Zhang Xiaoying, Luo Guanghua, Xu Ning   +3 more
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The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations [PDF]

Twin Research, 2000
AbstractThe effects of apolipoprotein (a), apolipoprotein-E, and apolipoprotein-A4 isoforms on quantitative lipoprotein(a) [Lp(a)] levels were assessed in a sample of 142 Dutch families consisting of two parents and their adolescent twin offspring. A total heritability of 95% was estimated for plasma Lp(a) concentrations.
Boomsma, D. I., Knijff, P., Kaptein, A., Labeur, C., Martin, N. G., Havekes, L. M., Princen, H. M.   +6 more
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PCSK9 loss-of-function variants and Lp(a) phenotypes among black US adults

Journal of Lipid Research, 2019
The pharmacologic inhibition of proprotein convertase subtilisin-kexin type 9 (PCSK9) lowers lipoprotein (a) [Lp(a)] concentrations. However, the impact of genetic PCSK9 loss-of-function variants (LOFVs) on Lp(a) is uncertain.
Matthew T. Mefford, Santica M. Marcovina, Vera Bittner, Mary Cushman, Todd M. Brown, Michael E. Farkouh, Sotirios Tsimikas, Keri L. Monda, J. Antonio G. López, Paul Muntner, Robert S. Rosenson   +10 more
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Varied Relationship of Lipid and Lipoprotein Profiles to Liver Fat Content in Phenotypes of Metabolic Associated Fatty Liver Disease

Frontiers in Endocrinology, 2021
BackgroundProgressive overloads of intrahepatic triglycerides are related to metabolic dysregulation of multiple lipid and lipoprotein profiles, but whether similar dose effects are found in each subtype of metabolic associated fatty liver disease (MAFLD)
Tingfeng Wu, Junzhao Ye, Congxiang Shao, Fuxi Li, Yansong Lin, Qianqian Ma, Wei Wang, Shiting Feng, Bihui Zhong   +8 more
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D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma[S]

Journal of Lipid Research, 2011
Asthma is characterized by oxidative stress and inflammation of the airways. Although proinflammatory lipids are involved in asthma, therapies targeting them remain lacking. Ac-DW F KA F YDKVAEK F KEA F NH2 (4F) is an apolipoprotein (apo)A-I mimetic that
S.D. Nandedkar, D. Weihrauch, H. Xu, Y. Shi, T. Feroah, W. Hutchins, D.A. Rickaby, N. Duzgunes, C.A. Hillery, K.S. Konduri, Jr.K.A. Pritchard   +10 more
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Cellular cholesterol efflux in heterozygotes for Tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size

Journal of Lipid Research, 2000
Tangier disease (TD), caused by mutations in the ATP-binding cassette 1 (ABC-1) gene, is a rare genetic disorder characterized by severe deficiency of high density lipoproteins (HDL) in the plasma, hypercatabolism of HDL, and defective apolipoprotein ...
Margaret E. Brousseau, Gretchen P. Eberhart, Josée Dupuis, Bela F. Asztalos, Allison L. Goldkamp, Ernst J. Schaefer, Mason W. Freeman   +6 more
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Degradation of human apolipoprotein B‐100 by apolipoprotein(a)

FEBS Letters, 1993
Human plasma low density lipoproteine (LDL) contain a very high molecular weight protein termed apoB‐100 (M r = 550,000). In many samples of LDL, minor components designated as apoB‐74 (M r = 407,000) and apoB‐26 (M r = 145,000) are present. It has been shown that they can arise as a result of proteolytic degradation of apoB‐100.
Chulkova, T.M., Tertov, V.V.
openaire   +2 more sources