Results 81 to 90 of about 23,930 (202)

Systemic impact of intramuscular snake envenomation and intravenous immunoglobulin‐based antivenom treatment on murine plasma proteome and peptidome

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Snake envenomation remains a critical global public health challenge. In Brazil, the genus Bothrops is responsible for most accidents, typically resulting in coagulopathy, hemorrhage, and renal failure. Despite its clinical prevalence, the molecular mechanisms driving plasma protein disturbances remain poorly understood.
Bianca C. S. C. de Barros, Alison F. A. Chaves, Mariana S. L. C. Morone, Ana T. A. Sachetto, Marcelo L. Santoro, Oliver Schilling, Solange M. T. Serrano   +6 more
wiley   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Serum apolipoprotein A1: a predictor and prognostic biomarker in acute ischemic stroke

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2019
Background The apolipoprotein A1 level is recognized as a better indicator of cardiovascular disease than other cholesterol measures. Objectives To assess the serum level of ApoA1 in acute stroke patients and correlate it with the degree of vessel ...
Mai A. Eldeeb, Amr S. Zaki, Samia Ashour, Azza Abdel Nasser, Ahmed El Bassiouny, Khaled O. Abdulghani   +5 more
doaj   +1 more source

Characterization of [18F]SMBT‐1 binding substrates in Alzheimer's disease and related disorders: A postmortem biochemical and immunohistochemical study

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Neuroimaging studies report associations of amyloid beta (Aβ) positron emission tomography (PET) with [18F](S)‐(2‐methylpyrid‐5‐yl)‐6‐[(3‐fluoro‐2‐hydroxy)propoxy]quinoline ([18F]SMBT‐1), a novel reactive astrogliosis surrogate radiotracer with high affinity for monoamine oxidase B (MAO‐B) in Alzheimer's disease (AD).
Eric E. Abrahamson, Julia K. Kofler, Oscar L. Lopez, Anne D. Cohen, Alexandra Gogola, Howard J. Aizenstein, Thomas K. Karikari, Elliott J. Mufson, Victor L. Villemange, Milos D. Ikonomovic   +9 more
wiley   +1 more source

Relationships Between the Apolipoprotein Levels and Sarcopenia in Inpatients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Diabetes, Metabolic Syndrome and Obesity
Yang Sun,1,2 Bo-Wei Liu,2 Xin Zhang,2 Fu-Zai Yin2 1Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, People’s Republic of ChinaCorrespondence: Fu ...
Sun Y, Liu BW, Zhang X, Yin FZ
doaj  

Inhibition of Moesin and CD44 in stem cell‐derived neurons affects the pathological genetic signature associated with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Post mortem proteomic analysis of Alzheimer's disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced pluripotent stem cells (hiPSCs)‐derived neurons, we assayed how reducing gene expression of ...
Eiden H. Brewer, Charles A. Williams, Gregory A. Cary, Ranjita Betarbet, Inez K. A. Pranoto, Elizabeth L. Zoeller, Haian Fu, Allan I. Levey, Jesse C. Wiley, Gregory W. Carter, Jessica E. Young, for the TREAT‐AD Consortium   +11 more
wiley   +1 more source

Association of polymorphism apolipoprotein A1 with the lipid profile serum

Атеросклероз, 2010
Objective: to investigate apolipoprotein AI gene polymorphism and its associations with lipid profile in Caucasian population of West Siberia. The study included 100 persons with total cho lesterol >300 mg/dl, 100 – with total cholesterol < 200 mg/dl ...
E. V. Schakhtschneider, I. V. Kulikov, M. V. Ivanova, M. I. Voevoda   +3 more
doaj  

Relationship between lipid metabolism, coagulation and other blood indices and etiology and staging of non-traumatic femoral head necrosis: a multivariate logistic regression-based analysis

Journal of Orthopaedic Surgery and Research
Background To analyze the relationship between lipid metabolism, coagulation function, and bone metabolism and the contributing factor and staging of non-traumatic femoral head necrosis, and to further investigate the factors influencing the blood ...
Ximing Yu, Shilu Dou, Liaodong Lu, Meng Wang, Zhongfeng Li, Dongwei Wang   +5 more
doaj   +1 more source

Dual Functions of Dietary Rubber Seed Oil Supplementation: Enriching N‐3 Polyunsaturated Fatty Acids and Enhancing Antioxidant Capacity in Pekin Ducks

Animal Research and One Health, Volume 4, Issue 3, Page 247-260, August 2026.
Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang, Yongbao Wu, Zitao Zhao, Junting Cao, Yanhong Guo, Zhanyue Wu, Qimeng Wang, Peilong Yang, Sen Wu, Zhiguo Wen, Shuisheng Hou   +10 more
wiley   +1 more source

神经系统健康人群的血脂参数与颈动脉斑块之间的相关性 Correlation between Lipid Parameters and Carotid Plaque in the Neurologically Healthy Population

Zhongguo cuzhong zazhi
目的 探讨在神经系统健康人群中，血脂参数与颈动脉斑块（carotid plaque，CP）之间的相关性。 方法 回顾性连续纳入2022年10月—2023年10月在首都医科大学附属北京天坛医院健康管理中心进行健康检查的神经系统健康人群。受试者接受了标准化问卷调查、体格检查、颈部血管超声以及实验室检测。通过标准颈动脉超声成像技术评估CP情况。CP的定义为颈动脉内膜-中层厚度≥1.5 mm。采用logistic回归和限制性立方样条（restricted cubic spline，RCS ...
李雯博1，刘阳2，刘洁1，郭齐瑞3，张莹2，郑华光2，4 （LI Wenbo1, LIU Yang2, LIU Jie1, GUO Qirui3, ZHANG Ying2, ZHENG Huaguang2,4 ）
doaj   +1 more source