Results 81 to 90 of about 23,783 (200)

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Serum apolipoprotein A1: a predictor and prognostic biomarker in acute ischemic stroke

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2019
Background The apolipoprotein A1 level is recognized as a better indicator of cardiovascular disease than other cholesterol measures. Objectives To assess the serum level of ApoA1 in acute stroke patients and correlate it with the degree of vessel ...
Mai A. Eldeeb, Amr S. Zaki, Samia Ashour, Azza Abdel Nasser, Ahmed El Bassiouny, Khaled O. Abdulghani   +5 more
doaj   +1 more source

Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) recently celebrated its 20th anniversary, reflecting two decades of major contributions to Alzheimer's research through open data sharing and longitudinal multimodal assessments. This review synthesizes 122 high‐impact studies using ADNI data or biospecimens from 2023 to mid‐2025 to ...
Dallas P. Veitch, Melanie J. Miller, Shaveta Kanoria, Paul S. Aisen, Laurel A. Beckett, Robert C. Green, Danielle J. Harvey, Clifford R. Jack Jr., William Jagust, Edward B. Lee, Kwangsik Nho, Rachel Nosheny, Ozioma C. Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, Susan M Landau, Michael W. Weiner, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

CYP46A1‐Targeted Treatment Alleviates Long‐Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Lin Li, You Shi, Qing Luo, Peiwen Guo, Taotao Jin, Xufang Ru, Zhouyang Jiang, Yin Niu, Wenyan Li, Yujie Chen, Zhi Chen   +10 more
wiley   +1 more source

Relationships Between the Apolipoprotein Levels and Sarcopenia in Inpatients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Diabetes, Metabolic Syndrome and Obesity
Yang Sun,1,2 Bo-Wei Liu,2 Xin Zhang,2 Fu-Zai Yin2 1Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, People’s Republic of ChinaCorrespondence: Fu ...
Sun Y, Liu BW, Zhang X, Yin FZ
doaj  

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Relationship between lipid metabolism, coagulation and other blood indices and etiology and staging of non-traumatic femoral head necrosis: a multivariate logistic regression-based analysis

Journal of Orthopaedic Surgery and Research
Background To analyze the relationship between lipid metabolism, coagulation function, and bone metabolism and the contributing factor and staging of non-traumatic femoral head necrosis, and to further investigate the factors influencing the blood ...
Ximing Yu, Shilu Dou, Liaodong Lu, Meng Wang, Zhongfeng Li, Dongwei Wang   +5 more
doaj   +1 more source

Association of polymorphism apolipoprotein A1 with the lipid profile serum

Атеросклероз, 2010
Objective: to investigate apolipoprotein AI gene polymorphism and its associations with lipid profile in Caucasian population of West Siberia. The study included 100 persons with total cho lesterol >300 mg/dl, 100 – with total cholesterol < 200 mg/dl ...
E. V. Schakhtschneider, I. V. Kulikov, M. V. Ivanova, M. I. Voevoda   +3 more
doaj  

神经系统健康人群的血脂参数与颈动脉斑块之间的相关性 Correlation between Lipid Parameters and Carotid Plaque in the Neurologically Healthy Population

Zhongguo cuzhong zazhi
目的 探讨在神经系统健康人群中，血脂参数与颈动脉斑块（carotid plaque，CP）之间的相关性。 方法 回顾性连续纳入2022年10月—2023年10月在首都医科大学附属北京天坛医院健康管理中心进行健康检查的神经系统健康人群。受试者接受了标准化问卷调查、体格检查、颈部血管超声以及实验室检测。通过标准颈动脉超声成像技术评估CP情况。CP的定义为颈动脉内膜-中层厚度≥1.5 mm。采用logistic回归和限制性立方样条（restricted cubic spline，RCS ...
李雯博1，刘阳2，刘洁1，郭齐瑞3，张莹2，郑华光2，4 （LI Wenbo1, LIU Yang2, LIU Jie1, GUO Qirui3, ZHANG Ying2, ZHENG Huaguang2,4 ）
doaj   +1 more source

Impact of Isolation Techniques on the Content of Small Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT An important topic of discussion amongst the extracellular vesicle (EV) research field is which genetic materials are considered true constituents of EV cargo. What were once regarded as non‐EV components have now evolved to be potentially essential to EV composition, serving as key mediators in communication.
Yue Su, Kekoolani S. Visan, Sarah Voss, Marta Prieto‐Vila, Juntaro Matsuzaki, Jason Ying Kuen Chan, Judy Wai Ping Yam, Andreas Möller   +7 more
wiley   +1 more source