Results 71 to 80 of about 23,930 (202)

AI‐Assisted Literature Mining Reveals Spatiotemporal Heterogeneity and Progression Trajectories of Traditional Chinese Medicine Syndromes in Coronary Heart Disease in China

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Despite the centrality of syndrome differentiation in guiding personalized traditional Chinese medicine (TCM) interventions for coronary heart disease (CHD), existing studies of TCM syndrome distribution are constrained by fragmented methodologies and limited spatiotemporal resolution. In this study, we employed an artificial intelligence (AI)‐
Qianzi Che, Tian Song, Zhaoyuan Gong, Chuxuan Wang, Bin Liu, Mingzhi Hu, Ning Liang, Haili Zhang, Huizhen Li, Qingyang Zeng, Lin Chen, Yuanming Leng, Xihao Cao, Jing Wan, Jing Guo, Nannan Shi   +15 more
wiley   +1 more source

EFFECT OF DABIGATRAN ON SERUM APOLIPOPROTEIN B AND APOLIPOPROTEIN A1 CONCENTRATIONS

Journal of the American College of Cardiology, 2013
Dabigatran is a direct thrombin inhibitor that reduces stroke risk in patients with atrial fibrillation and additional thromboembolic risk factors. Carboxylesterases, which convert dabigatran etexilate to its’ active form, dabigatran, have also been shown to influence lipid metabolism ...
Joseph, Philip, Pare, Guillaume, Connolly, Stuart, Ezekowitz, Michael, Wallentin, Lars, Reilly, Paul, Themeles, Ellison, Yusuf, Salim   +7 more
openaire   +1 more source

A Multimodal Machine Learning Model for Framingham Risk Score–Based Cardiovascular Risk Stratification in Patients With Obstructive Sleep Apnea

Journal of Sleep Research, EarlyView.
ABSTRACT Machine learning provides a powerful tool to capture complex, nonlinear patterns in biomedical data and enhance precision risk stratification. In this study, we applied a multilayer perceptron (MLP) framework to classify Framingham Risk Score–based cardiovascular risk categories in patients with obstructive sleep apnea (OSA).
Feng Zhao, Yin Li, Chenyang Li, Huajun Xu, Enhui Zhou, Weijun Huang, Huaming Zhu, Jian Guan, Hongliang Yi, Jianyin Zou, Nutan Chen   +10 more
wiley   +1 more source

Hormonal regulation of apolipoprotein A1

, 1994
Bibliography: p. 154-162.
openaire   +2 more sources

Beyond biologic sex: Exploratory insights into the heterogeneity of hormonal and contextual drivers of periodontal and peri‐implant outcomes

Periodontology 2000, EarlyView.
Abstract Background Periodontal and peri‐implant diseases are multifactorial inflammatory conditions influenced by microbial, host, hormonal, genetic, and behavioral factors. Although sex‐based differences in immune and inflammatory responses are well recognized in medicine, the extent to which biologic sex and hormonal status influence the prevalence,
Caitlin Neapole, Mark Gettas, Roberto Farina, Yvonne Hernandez‐Kapila   +3 more
wiley   +1 more source

Sex differences in apolipoprotein A1 and nevirapine‐induced toxicity

Journal of the International AIDS Society, 2014
Nevirapine (NVP) is associated with severe liver and skin toxicity through sulfotransferase (SULT) bioactivation of the phase I metabolite 12‐hydroxy‐NVP [1–3]. The female sex, a well‐known risk factor for NVP‐induced toxicity, is associated with higher SULT expression [4] and lower plasma levels of 12‐hydroxy‐NVP [3]. Interestingly, apolipoprotein A1 (
Marinho, A, Dias, C, Antunes, A, Caixas, U, Branco, T, Marques, M, Monteiro, E.C., SA, Pereira   +7 more
openaire   +3 more sources

Septic Shock and Prognosis in Dogs and Cats With Sepsis—Consensus Definition and Clinical Criteria

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Death from sepsis results from progressive organ dysfunction. Early recognition of increased illness severity or deterioration in clinical status enables timely interventions that can improve outcomes. We aimed to define septic shock by consensus and to use the existing literature to identify associated clinical and clinicopathologic ...
Robert Goggs, Stefano Cortellini, Amy E. DeClue, Massimo Giunti, Kate Hopper, Julie M. Menard, Rodrigo C. Rabelo, Elizabeth A. Rozanski, Claire R. Sharp, Deborah C. Silverstein, Virginia Sinnott‐Stutzman, Giacomo Stanzani, John Bourgeois, Erik Fausak   +13 more
wiley   +1 more source

Ovarian hormone loss modifies the nucleic acid cargo of circulating extracellular vesicles and skeletal muscle metabolism after acute exercise in rats

Experimental Physiology, EarlyView.
Abstract Loss of ovarian hormones (i.e., menopause) leads to negative effects on metabolic health. While exercise offers significant benefits, it seems to be insufficient to completely reverse these changes. The mechanisms by which exercise conveys the effects throughout the body are still poorly understood.
Veera Puumalainen, Anni Maja, Tia‐Marje Korhonen, Tuuli A. Nissinen, Eero Hulkko, Janne A. Ihalainen, Maarit Lehti, Sira Karvinen   +7 more
wiley   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source