Results 1 to 10 of about 77,676 (146)

Structure of apolipoprotein B-100 in low density lipoproteins [PDF]

Journal of Lipid Research, 2001
There is general consensus that amphipathic α-helices and β sheets represent the major lipid-associating motifs of apolipoprotein (apo)B-100. In this review, we examine the existing experimental and computational evidence for the pentapartite domain ...
Jere P. Segrest, Martin K. Jones, Hans De Loof, Nassrin Dashti   +3 more
doaj   +3 more sources

Mini-Review: Immunogenic epitopes in apolipoprotein B-100 for atheroprotective immunization [PDF]

Frontiers in Cardiovascular Medicine
Here, we provide a concise overview of recent developments in the identification of immunogenic epitopes in human apolipoprotein B-100 for immunization against atherosclerotic cardiovascular disease.
Norbert Gerdes, Norbert Gerdes, Roland Klingenberg, Roland Klingenberg   +3 more
doaj   +2 more sources

High prevalence of familial defective apolipoprotein B-100 in Switzerland.

Journal of Lipid Research, 1994
Familial defective apolipoprotein B-100 (FDB) is caused by a single G-to-A substitution at nucleotide 10,708 leading to an arginine to glutamine change at amino acid 3,500 of the apolipoprotein B-100 and thus, a reduced binding of the apolipoprotein B to
A R Miserez, R Laager, N Chiodetti, U Keller   +3 more
doaj   +4 more sources

Rapid Diagnosis of Familial Defective Apolipoprotein B-100 [PDF]

Clinical Chemistry and Laboratory Medicine, 1991
A method is described for the rapid, economic and non-radioactive examination of DNA samples from hypercholesterolaemic patients for familial defective apolipoprotein B-100, using a modified polymerase chain reaction (PCR) protocol and restriction enzyme isoform genotyping.
Geisel, J., Schleifenbaum, T., Weisshaar, Bernd, Oette, K.   +3 more
openaire   +3 more sources

Oxidative events cause degradation of apoB-100 but not of apo[a] and facilitate enzymatic cleavage of both proteins

Journal of Lipid Research, 2001
Lipoprotein [a] (Lp[a]) contains equimolar amounts of apoB-100 and apolipoprotein [a] (apo[a]). Both proteins are amenable to degradation in vivo by mechanisms yet to be clearly defined.
Celina Edelstein, Kei Nakajima, Ditta Pfaffinger, Angelo M. Scanu   +3 more
doaj   +1 more source

Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.

Journal of Lipid Research, 1990
Familial defective apolipoprotein B-100 is a genetic disorder of apolipoprotein B-100 that causes moderate to severe hypercholesterolemia. A single amino acid mutation in apolipoprotein B diminishes the ability of low density lipoproteins to bind to the ...
TL Innerarity, RW Mahley, KH Weisgraber, TP Bersot, RM Krauss, GL Vega, SM Grundy, W Friedl, J Davignon, BJ McCarthy   +9 more
doaj   +1 more source

Apolipoprotein[a] secretion from hepatoma cells is regulated in a size-dependent manner by alterations in disulfide bond formation

Journal of Lipid Research, 2003
Apolipoprotein[a] (apo[a]) is a large disulfide linked glycoprotein synthesized by hepatocytes. We have examined the role of disulfide bond formation in the processing of apo[a] using human and rat hepatoma cells expressing apo[a] isoforms containing ...
Fatiha Nassir, Yan Xie, Nicholas O. Davidson   +2 more
doaj   +1 more source

Human Placenta Secretes Apolipoprotein B-100-containing Lipoproteins [PDF]

Journal of Biological Chemistry, 2004
Supply of lipids from the mother is essential for fetal growth and development. In mice, disruption of yolk sac cell secretion of apolipoprotein (apo) B-containing lipoproteins results in embryonic lethality. In humans, the yolk sac is vestigial. Nutritional functions are instead established very early during pregnancy in the placenta.
Munk-Madsen, Eva, Lindegaard, Marie Louise Skakkebæk, Andersen, Claus B, Damm, Peter, Nielsen, Lars B   +4 more
openaire   +3 more sources

PPARα deficiency increases secretion and serum levels of apolipoprotein B-containing lipoproteins

Journal of Lipid Research, 2001
This study investigates the importance of peroxisome proliferator activated receptor α (PPARα) for serum apolipoprotein B (apoB) levels and hepatic secretion of apoB-containing lipoproteins.
Daniel Lindén, Mikael Alsterholm, Håkan Wennbo, Jan Oscarsson   +3 more
doaj   +1 more source

Degradation of human apolipoprotein B‐100 by apolipoprotein(a)

FEBS Letters, 1993
Human plasma low density lipoproteine (LDL) contain a very high molecular weight protein termed apoB‐100 (M r = 550,000). In many samples of LDL, minor components designated as apoB‐74 (M r = 407,000) and apoB‐26 (M r = 145,000) are present. It has been shown that they can arise as a result of proteolytic degradation of apoB‐100.
Chulkova, T.M., Tertov, V.V.
openaire   +2 more sources