Structure of apolipoprotein B-100 in low density lipoproteins [PDF]
Journal of Lipid Research, 2001 There is general consensus that amphipathic α-helices and β sheets represent the major lipid-associating motifs of apolipoprotein (apo)B-100. In this review, we examine the existing experimental and computational evidence for the pentapartite domain ...
Jere P. Segrest +3 more
doaj +4 more sources
High prevalence of familial defective apolipoprotein B-100 in Switzerland. [PDF]
Journal of Lipid Research, 1994 Familial defective apolipoprotein B-100 (FDB) is caused by a single G-to-A substitution at nucleotide 10,708 leading to an arginine to glutamine change at amino acid 3,500 of the apolipoprotein B-100 and thus, a reduced binding of the apolipoprotein B to
A R Miserez +3 more
doaj +6 more sources
VLDL and IDL apolipoprotein B-100 kinetics in familial hypercholesterolemia due to impaired LDL receptor function or to defective apolipoprotein B-100 [PDF]
Journal of Lipid Research, 1998 Mutations in the apolipoprotein (apo) B, E (LDL) receptor gene and in the apolipoprotein B-100 gene are the cause of familial hypercholesterolemia (FH) and of familial defective apo B-100 (FDB), respectively.
Henryk Zulewski +4 more
doaj +2 more sources
Asymmetric distribution of pause transfer sequences in apolipoprotein B-100
Journal of Lipid Research, 1997 Lipoprotein assembly requires a complex and regulated set of events that includes apolipoprotein B (apoB) translocation across the endoplasmic reticulum (ER) membrane, folding, and association with lipids.
M H Kivlen +3 more
doaj +2 more sources
Effect of apolipoprotein E genotype on apolipoprotein B-100 metabolism in normolipidemic and hyperlipidemic subjects [PDF]
Journal of Lipid Research, 2010 The effect of apolipoprotein (apo) E genotype on apoB-100 metabolism was examined in three normolipidemic apoE2/E2, five type III hyperlipidemic apoE2/E2, and five hyperlipidemic apoE3/E2 subjects using simultaneous administration of 131I-VLDL and 125I ...
Esther M.M. Ooi +4 more
doaj +2 more sources
Mini-Review: Immunogenic epitopes in apolipoprotein B-100 for atheroprotective immunization [PDF]
Frontiers in Cardiovascular MedicineHere, we provide a concise overview of recent developments in the identification of immunogenic epitopes in human apolipoprotein B-100 for immunization against atherosclerotic cardiovascular disease.
Norbert Gerdes +3 more
doaj +2 more sources
Mutation of lysine residues in apolipoprotein B-100 causes defective lipoprotein[a] formation [PDF]
Journal of Lipid Research, 2004 Lipoprotein[a] (Lp[a]) is assembled by a two-step process involving an initial lysine-dependent binding between apolipoprotein B-100 (apoB-100) and apolipoprotein[a] (apo[a]) that facilitates the formation of a disulphide bond between apoB-100Cys4,326 ...
Catherine Y.Y. Liu +3 more
doaj +2 more sources
Structural Domains of Human Apolipoprotein B-100
Journal of Biological Chemistry, 1989 G C Chen +5 more
openalex +2 more sources
Rapid Diagnosis of Familial Defective Apolipoprotein B-100 [PDF]
Clinical Chemistry and Laboratory Medicine, 1991 A method is described for the rapid, economic and non-radioactive examination of DNA samples from hypercholesterolaemic patients for familial defective apolipoprotein B-100, using a modified polymerase chain reaction (PCR) protocol and restriction enzyme isoform genotyping.
Geisel, J. +3 more
openaire +3 more sources
White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines. [PDF]
, 2012 The apolipoprotein E4 (ApoE4) is an established risk factor for Alzheimer's disease (AD). Previous work has shown that this allele is associated with functional (fMRI) changes as well structural grey matter (GM) changes in healthy young, middle-aged and ...
Hampel, Harald +7 more
core +7 more sources