Effects of a thyromimetic on apolipoprotein B-100 in rats [PDF]
Journal of Molecular Endocrinology, 2000 We have studied the effects of a cardiac sparing thyromimetic, CGS 23425, on postprandial levels of triglycerides, abundance of apolipoprotein B (apo B) protein and hepatic apo B mRNA expression in rats. When compared with control rats, triglyceride clearance was significantly accelerated by treatment with CGS 23425.
Yoshinaru Wada +6 more
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Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects. [PDF]
Journal of Clinical Investigation, 1991 This study examined apolipoprotein (apo) B metabolism in normolipemic subjects homozygous for the apo E2 (n = 4), apo E3 (n = 5), or apo E4 (n = 5) phenotype. Radioiodinated very low density lipoprotein (VLDL1) (ultracentrifuge flotation rate [Sf] 60-400) and VLDL2 (Sf 20-60) were injected into volunteers and the conversion of apo B was followed ...
Thomas Demant +3 more
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High prevalence of familial defective apolipoprotein B-100 in Switzerland. [PDF]
Journal of Lipid Research, 1994 Familial defective apolipoprotein B-100 (FDB) is caused by a single G-to-A substitution at nucleotide 10,708 leading to an arginine to glutamine change at amino acid 3,500 of the apolipoprotein B-100 and thus, a reduced binding of the apolipoprotein B to the low density lipoprotein (LDL) receptor.
André R. Miserez +3 more
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Localization of apolipoprotein(a) and B-100 in various renal diseases
Kidney International, 1993 Recently it has become clear that abnormalities of lipid metabolism play a large role in the progression of renal diseases. To investigate the relationship between lipids and kidney tissue, we employed an immunofluorescent technique to determine the localization pattern of apolipoprotein(a) [apo(a)], apoB-100, and low-density lipoprotein receptor in ...
Hirokazu Sato +6 more
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Determination of the molecular mass of apolipoprotein B-100 A chemical approach [PDF]
Biochemical Journal, 1986 Apolipoprotein B-100 (apo B-100) is the protein ligand in low-density lipoproteins that binds to a specific cell-surface receptor. Its molecular mass has been a subject of controversy. We have determined the molecular mass of the protein by a chemical approach.
Chao Yang +5 more
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Structure of apolipoprotein B-100 in low density lipoproteins [PDF]
Journal of Lipid Research, 2001 There is general consensus that amphipathic alpha-helices and beta sheets represent the major lipid-associating motifs of apolipoprotein (apo)B-100. In this review, we examine the existing experimental and computational evidence for the pentapartite domain structure of apoB.
Jere P. Segrest +3 more
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Liver damage promotes pro‐inflammatory T‐cell responses against apolipoprotein B‐100
Journal of Internal Medicine, 2021 Liver‐derived apolipoprotein B‐100 (ApoB100) is an autoantigen that is recognized by atherogenic CD4+ T cells in cardiovascular disease (CVD). CVD is a major mortality risk for patients with chronic inflammatory liver diseases.
Bastian F. J. Plochg +12 more
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Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence.
Proceedings of the National Academy of Sciences of the United States of America, 1986 Human apolipoprotein B-100 (apoB-100), the ligand on low density lipoproteins that interacts with the low density lipoprotein receptor and initiates receptor-mediated endocytosis and low density lipoprotein catabolism, has been cloned, and the complete ...
S W Law +6 more
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Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: No accentuation by apolipoprotein(a) [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1998 We have generated mice with markedly elevated plasma levels of human low density lipoprotein (LDL) and reduced plasma levels of high density lipoprotein. These mice have no functional LDL receptors [LDLR-/-] and express a human apolipoprotein B-100 (apoB)
David A. Sanan +7 more
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Identification of a Critical Lysine Residue in Apolipoprotein B-100 That Mediates Noncovalent Interaction with Apolipoprotein(a) [PDF]
Journal of Biological Chemistry, 2001 We have previously shown that lipoprotein(a) (Lp(a)) assembly involves an initial noncovalent interaction between sequences within apolipoprotein(a) (apo(a)) kringle IV types 5-8 and the amino terminus of apolipoprotein B-100 (sequences between amino acids 680 and 781 in apoB-100), followed by formation of a disulfide bond.
Lev Becker +4 more
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