Results 11 to 20 of about 634,093 (256)

Structural changes induced by acidic pH in human apolipoprotein B-100 [PDF]

Scientific Reports, 2016
AbstractAcidification in the endosome causes lipoprotein release by promoting a conformational change in the LDLR allowing its recycling and degradation of LDL. Notwithstanding conformational changes occurring in the LDLR have expanded considerably, structural changes occurring in LDL particles have not been fully explored yet.
Fernández Higuero, José Ángel, Benito Vicente, Asier, Etxebarria Gallego, Aitor, González Milicua, José Carlos, Ostolaza Echabe, Elena Amaya, Arrondo, Jose Luis R., Martín Plágaro, César Augusto   +6 more
semanticscholar   +7 more sources

Apolipoprotein B-100-mediated motor neuron degeneration in sporadic amyotrophic lateral sclerosis [PDF]

Brain Commun, 2022
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by motor neuron degeneration. Approximately 90% of cases occur sporadically with no known cause while 10% are familial cases arising from known inherited genetic mutations ...
Jamie K Wong, Anna K Roselle, Taylor M Shue, Serena J E Shimshak, Joseph M Beaty, Nadia Celestin, Ivy Gao, Rose Griffin, M. Cudkowicz, S. Sadiq   +9 more
semanticscholar   +2 more sources

Relationship of Oxidized Phospholipids on Apolipoprotein B-100 to Cardiovascular Outcomes in Patients Treated With Intensive Versus Moderate Atorvastatin Therapy [PDF]

J Am Coll Cardiol, 2015
Young Sup Byun, Jun‐Hee Lee, Benoît J. Arsenault, Xiaohong Yang, Weihang Bao, David A. DeMicco, Rachel Laskey, Joseph L. Witztum, Sotirios Tsimikas   +8 more
semanticscholar   +3 more sources

A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease. [PDF]

J Infect Dis, 2015
To discover novel autoantigens associated with Lyme arthritis (LA), we identified T-cell epitopes presented in vivo by human leukocyte antigen (HLA)-DR molecules in patients' inflamed synovial tissue or joint fluid and tested each epitope for ...
J. T. Crowley, E. Drouin, A. Pianta, K. Strle, Qi Wang, C. Costello, A. Steere   +6 more
semanticscholar   +2 more sources

Cultured cells of the blood–brain barrier from apolipoprotein B-100 transgenic mice: effects of oxidized low-density lipoprotein treatment [PDF]

Fluids Barriers CNS, 2015
BackgroundThe apolipoprotein B-100 (ApoB-100) transgenic mouse line is a model of human atherosclerosis. Latest findings suggest the importance of ApoB-100 in the development of neurodegenerative diseases and microvascular/perivascular localization of ...
Nikolett Lénárt, F. Walter, Alexandra Bocsik, P. Sántha, Melinda E. Tóth, A. Harazin, A. Tóth, C. Vízler, Tony Alan Ratliff, Ana-Maria Pilbat, L. Vígh, L. Puskás, M. Santha, M. Deli   +13 more
semanticscholar   +2 more sources

Effect of apolipoprotein E genotype on apolipoprotein B-100 metabolism in normolipidemic and hyperlipidemic subjects [PDF]

Journal of Lipid Research, 2010
The effect of apolipoprotein (apo) E genotype on apoB-100 metabolism was examined in three normolipidemic apoE2/E2, five type III hyperlipidemic apoE2/E2, and five hyperlipidemic apoE3/E2 subjects using simultaneous administration of (131)I-VLDL and (125)I-LDL, and multi-compartmental modeling.
Esther Ooi, Edward Janus, Susan Grant, Lucia M. T. Sinclair, P. Hugh R. Barrett   +4 more
openalex   +6 more sources

Decreased bone mineral density in subjects carrying familial defective apolipoprotein B-100.

J Clin Endocrinol Metab, 2013
CONTEXT Although numerous epidemiologic studies have documented associations between osteoporosis and cardiovascular disease, the mechanisms underlying this association remain to be clarified.
L. Yerges-Armstrong, Haiqing Shen, K. Ryan, E. Streeten, A. Shuldiner, B. Mitchell   +5 more
semanticscholar   +2 more sources

Serum Apolipoprotein B-100 Concentrations in Healthy and Diseased Cattle.

Journal of Veterinary Medical Science, 1997
The purpose of this study was to establish the normal range of serum apolipoprotein B-100 (APO B-100) concentration in clinically normal cattle, and to assess its abnormalities with clinical diseases. We measured the serum concentration of APO B-100 in cattle of varying ages, breeds and sex, maintained under normal field conditions.
Hiroshi Itoh, Keiji Tamura, Yoshiko MOTOI, Fumio Kawawa   +3 more
openalex   +5 more sources

Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a) [PDF]

Metabolism, 2015
Lipoprotein(a) [Lp(a)] is mainly similar in composition to LDL, but differs in having apolipoprotein (apo) (a) covalently linked to apoB-100. Our purpose was to examine the individual metabolism of apo(a) and apoB-100 within plasma Lp(a).The kinetics of apo(a) and apoB-100 in plasma Lp(a) were assessed in four men with dyslipidemia [Lp(a) concentration:
Margaret R. Diffenderfer, Stefania Lamon‐Fava, Santica M. Marcovina, P. Hugh R. Barrett, Julian Lel, Gregory G. Dolnikowski, Lars Berglund, Ernst J. Schaefer   +7 more
openalex   +6 more sources

Genotypic associations of the hepatic secretion of VLDL apolipoprotein B-100 in obesity

Journal of Lipid Research, 2000
We examined the effect of genetic polymorphisms of proteins regulating intrahepatic processing of apolipoprotein B-100 (apoB) and the supply of neutral lipids to the liver on the hepatic secretion of very low density lipoprotein (VLDL) apoB in obesity. Hepatic secretion of very low density apolipoprotein B-100 (VLDL apoB) was measured using an infusion
Gerald F. Watts, F.M. Riches, Steve E. Humphries, Philippa J. Talmud, Frank M. van Bockxmeer   +4 more
openalex   +5 more sources