Results 1 to 10 of about 92,925 (293)

VLDL and IDL apolipoprotein B-100 kinetics in familial hypercholesterolemia due to impaired LDL receptor function or to defective apolipoprotein B-100 [PDF]

Journal of Lipid Research, 1998
Mutations in the apolipoprotein (apo) B, E (LDL) receptor gene and in the apolipoprotein B-100 gene are the cause of familial hypercholesterolemia (FH) and of familial defective apo B-100 (FDB), respectively.
Henryk Zulewski, Ron Ninnis, André R. Miserez, Manfred W. Baumstark, Ulrich Keller   +4 more
doaj   +7 more sources

Degradation of human apolipoprotein B‐100 by apolipoprotein(a)

FEBS Letters, 1993
Human plasma low density lipoproteine (LDL) contain a very high molecular weight protein termed apoB‐100 (M r = 550,000). In many samples of LDL, minor components designated as apoB‐74 (M r = 407,000) and apoB‐26 (M r = 145,000) are present. It has been shown that they can arise as a result of proteolytic degradation of apoB‐100.
Chulkova, T.M., Tertov, V.V.
openaire   +3 more sources

Rapid Diagnosis of Familial Defective Apolipoprotein B-100 [PDF]

Clinical Chemistry and Laboratory Medicine, 1991
A method is described for the rapid, economic and non-radioactive examination of DNA samples from hypercholesterolaemic patients for familial defective apolipoprotein B-100, using a modified polymerase chain reaction (PCR) protocol and restriction enzyme isoform genotyping.
Geisel, J., Schleifenbaum, T., Weisshaar, Bernd, Oette, K.   +3 more
openaire   +4 more sources

Structure of apolipoprotein B-100 in low density lipoproteins [PDF]

Journal of Lipid Research, 2001
There is general consensus that amphipathic α-helices and β sheets represent the major lipid-associating motifs of apolipoprotein (apo)B-100. In this review, we examine the existing experimental and computational evidence for the pentapartite domain ...
Jere P. Segrest, Martin K. Jones, Hans De Loof, Nassrin Dashti   +3 more
doaj   +3 more sources

Characterization and quantitation of apolipoprotein B-100 by capillary electrophoresis [PDF]

Journal of Lipid Research, 1998
The interaction of low density lipoproteins (LDL) with different surfactants was studied by capillary electrophoresis (CE) and sucrose density gradient ultracentrifugation as part of developing a method for quantitation of apoB-100 in serum. A mixture of
Ingrid D. Cruzado, Steven L. Cockrill, Catherine J. McNeal, Ronald D. Macfarlane   +3 more
doaj   +3 more sources

Mini-Review: Immunogenic epitopes in apolipoprotein B-100 for atheroprotective immunization [PDF]

Frontiers in Cardiovascular Medicine
Here, we provide a concise overview of recent developments in the identification of immunogenic epitopes in human apolipoprotein B-100 for immunization against atherosclerotic cardiovascular disease.
Norbert Gerdes, Norbert Gerdes, Roland Klingenberg, Roland Klingenberg   +3 more
doaj   +2 more sources

Effect of apolipoprotein E genotype on apolipoprotein B-100 metabolism in normolipidemic and hyperlipidemic subjects [PDF]

Journal of Lipid Research, 2010
The effect of apolipoprotein (apo) E genotype on apoB-100 metabolism was examined in three normolipidemic apoE2/E2, five type III hyperlipidemic apoE2/E2, and five hyperlipidemic apoE3/E2 subjects using simultaneous administration of 131I-VLDL and 125I ...
Esther M.M. Ooi, Edward D. Janus, Susan J. Grant, Lucia M.T. Sinclair, P. Hugh R.Barrett   +4 more
doaj   +3 more sources

Distribution, transport, and degradation of apolipoprotein B-100 in HepG2 cells

Journal of Lipid Research, 2001
The transport of apolipoprotein B (apoB) between the endoplasmic reticulum (ER) and Golgi was studied in puromycin-synchronized HepG2 cells, using an antibody that could distinguish between apoB in ER and Golgi compartments.
Nobuhiro Sakata, Thomas E. Phillips, Joseph L. Dixon   +2 more
doaj   +3 more sources

Effects of a thyromimetic on apolipoprotein B-100 in rats [PDF]

Journal of Molecular Endocrinology, 2000
We have studied the effects of a cardiac sparing thyromimetic, CGS 23425, on postprandial levels of triglycerides, abundance of apolipoprotein B (apo B) protein and hepatic apo B mRNA expression in rats. When compared with control rats, triglyceride clearance was significantly accelerated by treatment with CGS 23425.
Y, Wada, S, Matsubara, J, Dufresne, G M, Hargrove, Z F, Stephan, R E, Steele, N C, Wong   +6 more
openaire   +2 more sources

Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.

Journal of Lipid Research, 1990
Familial defective apolipoprotein B-100 is a genetic disorder of apolipoprotein B-100 that causes moderate to severe hypercholesterolemia. A single amino acid mutation in apolipoprotein B diminishes the ability of low density lipoproteins to bind to the ...
TL Innerarity, RW Mahley, KH Weisgraber, TP Bersot, RM Krauss, GL Vega, SM Grundy, W Friedl, J Davignon, BJ McCarthy   +9 more
doaj   +1 more source