Results 231 to 240 of about 634,093 (256)

Apolipoprotein B-100 Hopkins (Arginine4019 [unk] Tryptophan)

JAMA, 1989
A 43-year-old woman with severe coronary artery disease and hyperapobetalipoproteinemia was heterozygous for an abnormal Msp I apolipoprotein B (APOB) gene fragment because of the absence of the MspI site around codon 4046 in exon 29 of the APOB gene.
Michael I. Miller, Hazel H. Smith, Stylianos E. Antonarakis, John A. A. Ladias, Paul S. Bachorik, Trudy Forte, Aldons J. Lusis, Peter O. Kwiterovich   +7 more
openaire   +3 more sources

Lipoproteins Containing Apolipoprotein B-100 Are Secreted by the Heart

Trends in Cardiovascular Medicine, 1999
It generally is assumed that lipoproteins containing apolipoprotein B (apo B) are secreted only by the intestine and the liver. However, we recently demonstrated that the human apo-B gene also is expressed in the hearts of human apo-B transgenic mice and in human heart tissue.
Murielle M. Véniant, Stephen G. Young, Jan Borén, Lars Bo Nielsen   +3 more
openaire   +3 more sources

Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins

Biological Chemistry, 2006
Although the degradation of cellular or endocytosed proteins comprises the normal function of lysosomal proteinases, these enzymes were also detected extracellularly during diseases such as atherosclerosis. Since lysosomal cysteine cathepsins were demonstrated to transform native LDL particles into a proatherogenic type, the following study was ...
Gilles Lalmanach, Michèle Brillard, Martin Linke, Ronald E. Gordon, Dieter Brömme, Fabien Lecaille   +5 more
openaire   +3 more sources

Interaction of tryptic peptides of apolipoprotein B-100 with dimyristoylphosphatidylcholine

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
Apolipoprotein B-100, the major protein constituent of human plasma low-density lipoproteins (LDL), was carboxyamidomethylated, digested with trypsin and the water-soluble tryptic peptides were coincubated with liposomes of dimyristoylphosphatidylcholine (DMPC).
Alan D. Cardin, Richard L. Jackson
openaire   +3 more sources

Structural Domains of Apolipoprotein(a) and Its Interaction with Apolipoprotein B-100 in the Lipoprotein(a) Particle

Biochemistry, 1994
The structural domains of human apolipoprotein(a) [apo(a)] and its interaction with apolipoprotein B-100 (apo B-100) in the lipoprotein(a) [Lp(a)] particle were investigated by limited proteolysis with thermolysin and cathepsin D. We characterized the proteolytic products by sodium dodecyl sulfate-polyacrylamide gradient gel electrophoresis, followed ...
Hans Dieplinger, C. Doucet, Joëlle Thillet, Thierry Huby, James Chapman   +4 more
openaire   +3 more sources

Apolipoprotein B synthesis in humans: Liver synthesizes only apolipoprotein B-100

Metabolism, 1985
Apolipoprotein (apo) B-100 and B-48 are prominent apolipoproteins in VLDL, IDL, and chylomicrons. Organ cultures of normal adult human liver were established to ascertain the form of apo B synthesized by hepatocytes in humans. Human liver was minced and incubated in 15 mL methionine-free RPMI-1640 medium with 10% dialyzed fetal calf serum plus 250 ...
H.B. Brewer, Philip D. Schneider, Jeffrey M. Hoeg, Stephen B. Edge   +3 more
openaire   +3 more sources

[11] Isolation and characterization of apolipoprotein B-100

1986
Publisher Summary Two physically separable macromolecules carry the designation apolipoproteinB. The long recognized form of apoB, large apoB or B-100, is the predominant protein in LDL and the major apoB protein found in human VLDL. This chapter describes the isolation and characterization of apolipoprotein B-100.
Waldo R. Fisher, Verne N. Schumaker
openaire   +2 more sources

The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles

Atherosclerosis, 2010
The LPA I4399M (rs3798220) single nucleotide polymorphism (SNP) is associated with increased plasma levels of Lp(a) and advanced coronary artery disease (CAD). We hypothesized that carriers of the Met allele of the I4399M SNP would also have elevated levels of oxidized phospholipids (OxPL) on apoB (OxPL/apoB) particles.Plasma levels of Lp(a) and OxPL ...
Sotirios Tsimikas, Marlys L. Koschinsky, Kiyohito Arai, Joseph L. Witztum, Clive R. Pullinger, Elizabeth R. Miller, May M. Luke, John P. Kane   +7 more
openaire   +3 more sources

Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100

The Lancet, 1992
Familial defective apolipoprotein B-100 (FDB) is an autosomal dominant disorder associated with hypercholesterolaemia in which an aminoacid substitution in apoprotein B-100 leads to low-density lipoprotein (LDL) particles which have defective binding to the LDL receptor.
F. Vakar, Robert W. Mahley, Karl H. Weisgraber, D.R Illingworth   +3 more
openaire   +3 more sources

Apolipoprotein B-100 kinetics in visceral obesity: associations with plasma apolipoprotein C-III concentration.

Metabolism: Clinical and Experimental, 2002
Obesity is strongly associated with dyslipidemia, which may account for the associated increased risk of atherosclerosis and coronary disease. We aimed to test the hypothesis that kinetics of hepatic apolipoprotein B-100 (apoB) metabolism are disturbed ...
D. Chan, G. F. Watts, Trevor G. Redgrave, T. Mori, P. Barrett   +4 more
semanticscholar   +1 more source