Results 251 to 260 of about 92,925 (293)

Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins

Biological Chemistry, 2006
Although the degradation of cellular or endocytosed proteins comprises the normal function of lysosomal proteinases, these enzymes were also detected extracellularly during diseases such as atherosclerosis. Since lysosomal cysteine cathepsins were demonstrated to transform native LDL particles into a proatherogenic type, the following study was ...
Fabien Lecaille, Gilles Lalmanach, Dieter Bromme   +2 more
exaly   +3 more sources

Homozygous Familial Defective Apolipoprotein B-100

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
Familial defective apolipoprotein B-100 (FDB) is a frequently inherited disorder of lipoprotein metabolism. The glutamine-for-arginine substitution at position 3500 of apolipoprotein (apo) B-100 leads to defective binding of apo B-100 to the
J R Schaefer, Hubert Scharnagl, Manfred W Baumstark   +2 more
exaly   +2 more sources

Reduction of Lipid Hydroperoxides by Apolipoprotein B-100

Biochemical and Biophysical Research Communications, 1999
We have previously isolated two proteins which can reduce phosphatidylcholine hydroperoxide (PC-OOH) from human blood plasma and identified one of the proteins as apolipoprotein A-I (Mashima, R. , et al. (1998) J. Lipid Res. 39, 1133-1140). In the present study we have identified the other protein as apolipoprotein B-100 (apo B-100) by amino acid ...
R, Mashima, S, Yoshimura, Y, Yamamoto
openaire   +2 more sources

Genetic determinants of apolipoprotein B-100 kinetics

Current Opinion in Lipidology, 2010
We review stable isotope tracer studies of apolipoprotein B-100 (apoB) kinetics concerning genetic polymorphisms and mutations that affect human lipoprotein metabolism.In obese men, the allelic combination of the apoB signal peptide, SP24, and cholesteryl ester transfer protein, CETP B1B1, is independently associated with lower VLDL apoB secretion ...
Theodore W K, Ng, Esther M M, Ooi, Gerald F, Watts, Dick C, Chan, P Hugh R, Barrett   +4 more
openaire   +2 more sources

Degradation of apolipoprotein B-100 in human chylomicrons

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
The purpose of this study was to investigate the molecular forms of apolipoprotein B (ApoB) in human chylomicrons under well-preserved conditions. To this end, plasma and serum were collected from the same normal subjects after ingestion of a fatty meal.
D M, Lee, S, Singh
openaire   +2 more sources

Familial defective apolipoprotein B-100 in hypercholesterolemic Chinese Canadians: identification of a unique haplotype of the apolipoprotein B-100 allele

Atherosclerosis, 1997
Familial defective apo B-100 (FDB) is an autosomal dominant condition resulting in hypercholesterolemia. It is generally observed in 1-6% of hypercholesterolemic subjects in Caucasian populations studied. There are, thus far, no reports characterizing the frequency and phenotype of FDB in a Chinese population. We report on the frequency of the FDB (Arg(
L O, Abdel-Wareth, S N, Pimstone, J P, Lagarde, A, Raisonnier, P, Benlian, H, Pritchard, M R, Hayden, J J, Frohlich   +7 more
openaire   +2 more sources

Lipoproteins Containing Apolipoprotein B-100 Are Secreted by the Heart

Trends in Cardiovascular Medicine, 1999
It generally is assumed that lipoproteins containing apolipoprotein B (apo B) are secreted only by the intestine and the liver. However, we recently demonstrated that the human apo-B gene also is expressed in the hearts of human apo-B transgenic mice and in human heart tissue.
M M, Véniant, L B, Nielsen, J, Borén, S G, Young   +3 more
openaire   +2 more sources

Interaction of tryptic peptides of apolipoprotein B-100 with dimyristoylphosphatidylcholine

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
Apolipoprotein B-100, the major protein constituent of human plasma low-density lipoproteins (LDL), was carboxyamidomethylated, digested with trypsin and the water-soluble tryptic peptides were coincubated with liposomes of dimyristoylphosphatidylcholine (DMPC).
A D, Cardin, R L, Jackson
openaire   +2 more sources

Structural Domains of Apolipoprotein(a) and Its Interaction with Apolipoprotein B-100 in the Lipoprotein(a) Particle

Biochemistry, 1994
The structural domains of human apolipoprotein(a) [apo(a)] and its interaction with apolipoprotein B-100 (apo B-100) in the lipoprotein(a) [Lp(a)] particle were investigated by limited proteolysis with thermolysin and cathepsin D. We characterized the proteolytic products by sodium dodecyl sulfate-polyacrylamide gradient gel electrophoresis, followed ...
T, Huby, C, Doucet, H, Dieplinger, J, Chapman, J, Thillet   +4 more
openaire   +2 more sources

Apolipoprotein B synthesis in humans: Liver synthesizes only apolipoprotein B-100

Metabolism, 1985
Apolipoprotein (apo) B-100 and B-48 are prominent apolipoproteins in VLDL, IDL, and chylomicrons. Organ cultures of normal adult human liver were established to ascertain the form of apo B synthesized by hepatocytes in humans. Human liver was minced and incubated in 15 mL methionine-free RPMI-1640 medium with 10% dialyzed fetal calf serum plus 250 ...
S B, Edge, J M, Hoeg, P D, Schneider, H B, Brewer   +3 more
openaire   +2 more sources