Results 231 to 240 of about 92,925 (293)

Ex vivo comparison of ACU193 and lecanemab reveals binding differences in mouse brain

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Immunotherapy targeting amyloid beta (Aβ) is limited by amyloid‐related imaging abnormalities (ARIA), hypothesized to result from the direct binding of anti‐Aβ monoclonal antibodies (mAbs) to vascular cerebral amyloid angiopathy (CAA), eliciting an immune response.
Martine B. Grenon, Erika N. Cline, Jasna Jerecic, Elizabeth Johnson, Eric Siemers, Cynthia A. Lemere   +5 more
wiley   +1 more source

Plasma proteome is altered in a piglet model of fetal growth restriction. [PDF]

Sci Rep
Musco H, Lee A, Chand KK, Colditz PB, Wixey JA.   +4 more
europepmc   +1 more source

Sleep‐like slow waves during resting‐state: A promising EEG biomarker of amyloid and neurodegeneration in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Growing evidence supports a critical role of sleep slow waves (SW) in Alzheimer's disease (AD). However, wake SW (sleep‐like SW potentially reflecting local intrusions of sleep) remain unexplored in AD. METHODS A total of 274 older adults with subjective cognitive decline (SCD) (INSIGHT‐preAD cohort, 76.6 ± 3.5 years) underwent (i)
Pierre Champetier, Claudia Albero, Filipa Raposo Pereira, Rubén Herzog, Maximilien Chaumon, Marion Houot, Maxime Locatelli, Aurélie Kas, Marie‐Odile Habert, Marc Teichmann, Stéphane Epelbaum, Isabelle Arnulf, Delphine Oudiette, Thomas Andrillon, the INSIGHT‐preAD group   +14 more
wiley   +1 more source

Familial hypobetalipoproteinemia in pediatric patients with fatty liver: an under-recognized cause. [PDF]

Front Med (Lausanne)
Loberman Nachum N, Shteyer E, Cohen H, Chorin O, Granot M, Weiss B.   +5 more
europepmc   +1 more source

Outcome‐specific risk factors challenge universal dementia prevention priorities: Findings from the Egyptian Dementia Network Registry

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Graphical Abstract illustrating how the different risk factors relate to dementia diagnosis and cognitive performance. Solid arrows indicate robust associations in this cohort; dashed arrows indicate weaker or imprecise associations. Abstract BACKGROUND Dementia prevention targets modifiable factors from high‐income cohorts, but most studies conflate ...
Shimaa A. Heikal, Eman M. Khedr, Gharib Fawi, Mai Othman, Nesma G. Elsheikh, Heba M. Tawfik, Hany I. Hassanin, Sara ElFarrash, Samer Salama, Eman M. Ali, Amna Ibrahim, Ahmed Qayaty, Sara A. Moustafa, Mohamed Salama   +13 more
wiley   +1 more source

Lipid feature and late onset ≥80 years of ischemic stroke: a retrospective study in lipid-lowering therapy-naive adults. [PDF]

Front Neurol
Jiao S, Li Y, Yuan X, Cheng X.
europepmc   +1 more source

Differential associations of plasma biomarkers with Alzheimer's disease and small vessel disease: A multimodal imaging study

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION We investigated how plasma biomarkers (phosphorylated tau 217 [ptau217], glial fibrillary acidic protein [GFAP], neurofilament light chain [NfL]) relate to imaging markers of small vessel disease (SVD) and Alzheimer's disease (AD), and cognition in memory clinic patients.
Anna Dewenter, Katharina Bürger, Daniel Janowitz, Melina Paulus, Brigitte Nuscher, Fabian Hirsch, Benno Gesierich, Anna Steward, Lukas Frontzkowski, Sebastian N. Roemer‐Cassiano, Zeyu Zhu, Davina Biel, Madleen Klonowski, Gloria Biechele, Sophia Stoecklein, Michael Ewers, Marco Duering, Steffen Tiedt, Matthias Brendel, Nicolai Franzmeier, for the Alzheimer's Disease Neuroimaging Initiative (ADNI)   +20 more
wiley   +1 more source

A functional SNP rs12718466 in APOA1 promoter modulates gene expression via interaction with SOX7. [PDF]

J Biol Chem
Aita Y, Takeuchi Y, Masuda Y, Mehrazad Saber Z, Karkoutly S, Tao D, Ye C, Mendsaikhan T, Saikawa R, Kondo Y, Murayama Y, Shikama A, Matsuzaka T, Shimano H, Kawakami Y, Yahagi N.   +15 more
europepmc   +1 more source

Age‐related increase in plasma p‐tau217 in amyloid‐beta–negative cognitively unimpaired individuals affects diagnostic interpretation

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The extent to which non‐pathological aging influences plasma biomarkers remains unclear. Here, we investigate factors influencing plasma p‐tau217 levels in cognitively unimpaired (CU), amyloid‐beta–negative (Aβ‐) individuals. METHODS Plasma p‐tau217 was measured in CU Aβ‐ positron emission tomography–negative (PET‐) participants ...
Anna E Mammel, Fernando Gonzalez‐Ortiz, Ali Mousavi, Kelsey Hallett, Mary Encarnacion, Don Biehl, Pradip Gill, Sazan Ismael, Christopher Fowler, James D. Doecke, Larry Ward, Hans Frykman   +11 more
wiley   +1 more source

Factors associated with the occurrence of breast nodules in perimenopausal women: A cross-sectional study in China. [PDF]

Medicine (Baltimore)
Jiang X, Song L, Cai X, Zhang W, Meng L.
europepmc   +1 more source