Results 221 to 230 of about 92,925 (293)

From Failure to Promise: Obicetrapib and the Renaissance of Cholesteryl Ester Transfer Protein Inhibition in Atherosclerotic Cardiovascular Disease. [PDF]

J Am Heart Assoc
Prajapathi S, Mahajan K, Mohta A, Pradhan A.   +3 more
europepmc   +1 more source

A lifespan staging model of basal forebrain cholinergic vulnerability

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The cholinergic neurons of the basal forebrain are among the most vulnerable cell types to age‐ and Alzheimer's disease‐related dysfunction and neurodegeneration. However, the biological bases of basal forebrain cholinergic vulnerability (the why) and the temporal sequence (the how) have yet to be fully resolved.
Hayley R. C. Shanks, Sherry Chen, Kate M. Onuska, Taylor W. Schmitz   +3 more
wiley   +1 more source

Bionano Interface Optimization for Rational Lateral Flow Assay Development. [PDF]

ACS Nano
Sadler CJ, Miller M, Darmawan KK, Sandler JP, Ng HC, Shamsabadi A, Creamer A, Robinson CV, Yarovsky I, Stevens MM.   +9 more
europepmc   +1 more source

Endogenously generated Dutch‐type Aβ non‐fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract BACKGROUND APPE693Q (“Dutch”) transgenic mice develop aging‐related learning deficits and accumulate endogenously generated non‐fibrillar aggregates (NFAs) of amyloid beta (Aβ) and amyloid precursor protein α‐carboxy terminal fragments. NFA‐Aβ correlates with synaptic loss and memory deficits more closely than does fibrillar Aβ.
Emilie L. Castranio, Merina Varghese, Elentina K. Argyrousi, Kuldeep Tripathi, Yong Huang, Akiko Asada, Linda Söderberg, Erin Bresnahan, David Lerner, Francesca Garretti, Hong Zhang, Jonathan van de Loo, Cheryl D. Stimpson, Ronan Talty, Charles Glabe, Efrat Levy, Minghui Wang, Marjan Ilkov, Toshiharu Suzuki, Kanae Ando, Bin Zhang, Lars Lannfelt, Brigitte Guérin, William D. Lubell, Shai Rahimipour, Dara L. Dickstein, Sam Gandy, Ottavio Arancio, Michelle E. Ehrlich   +28 more
wiley   +1 more source

Elevated Apolipoprotein B Is Associated With an Increased Risk of Adverse Outcomes in Aortic Stenosis. [PDF]

JACC Adv
Bansal A, Kapadia SR.
europepmc   +1 more source

Emerging directions in tauopathy research

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of
Luc Buée, Kristin R. Wildsmith, Suvarna Alladi, Taylor Bertucci, Delphine Boche, Kathryn R. Bowles, Adam Boxer, Jennifer Brummet, Sarah L. DeVos, Kristophe Diaz, Anna Jane Dreyer, Karen Duff, Claudia Duran‐Aniotz, Claire S. Durrant, Kurt Farrell, Igor C. Fontana, Nicolai Franzmeier, Bess Frost, Kanta Horie, Petr Kaňovský, Aimee W. Kao, Simin Mahinrad, Maura Malpetti, Huw R. Morris, Carla Palleis, Leonard Petrucelli, Jessica Rexach, Larisa Reyderman, Amy Rommel, James B. Rowe, Sandra M. Sanabria Bohórquez, Chihiro Sato, Michael Schöll, Anja Schneider, Rohan de Silva, Heather M. Snyder, Lawren VandeVrede, Andrew W. Varga, Jacob W. Vogel, Felix L. Yeh, Andrew S. Yoo, Maria C. Carrillo   +41 more
wiley   +1 more source

Current and Emerging Pharmacological Therapies for Hypertriglyceridemia. [PDF]

Int J Mol Sci
Alhomoud IS.
europepmc   +1 more source

WSB.APP/PS1 mice develop age‐dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD‐relevant cerebrovascular phenotypes. METHODS CAA and parenchymal plaque analysis and in vivo neurovascular imaging were
Olivia J. Marola, Asli Uyar, Kelly J. Keezer, Juan Antonio K. Chong Chie, Kevin J. Elk, Abigail E. Cullen, Kierra Eldridge, Scott Persohn, Jonathan Nyandu Kanyinda, Jennifer D. Whitesell, Julie A. Harris, Paul Salama, Ashley E. Walker, Gregory W. Carter, Michael Sasner, Paul R. Territo, Gareth R. Howell, Kristen D. Onos   +17 more
wiley   +1 more source

Brain regional susceptibility to tauopathy in individuals at risk for chronic traumatic encephalopathy

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Chronic traumatic encephalopathy (CTE) is a tauopathy linked to repetitive head impacts. Factors influencing brain regional susceptibility to tau deposition and spreading remain unclear. METHODS We used three datasets: [18F]flortaucipir positron emission tomography (PET) in 157 former professional American football players and 53 ...
Tim L. T. Wiegand, Anna Rubinski, Leonard B. Jung, Nicolai Franzmeier, Hector Arciniega, Parsa Ravanfar, Anna Dewenter, Michael L. Alosco, Yorghos Tripodis, Yi Su, Hillary Protas, Alexander P. Lin, Ofer Pasternak, Kewei Chen, Michael J. Coleman, Sylvain Bouix, Charles H. Adler, Laura J. Balcer, Charles Bernick, Jeffrey L. Cummings, Robert A. Stern, Eric M. Reiman, Martha E. Shenton, Michael Ewers, Inga K. Koerte, for the DIAGNOSE CTE Research Project   +25 more
wiley   +1 more source

Artificial recombinant high-density protein nanocarriers for precision drug delivery. [PDF]

Chem Sci
Li W, Jia N, Li M, Jiang Y, Lu J.
europepmc   +1 more source