Results 21 to 30 of about 77,676 (146)

Apolipoprotein B-100 deficiency. Intestinal steatosis despite apolipoprotein B-48 synthesis. [PDF]

Journal of Clinical Investigation, 1985
We describe a child, the issue of phenotypically normal parents, who had fat malabsorption, both intestinal and hepatic steatosis, and serum cholesterol and triglyceride concentrations of 38 and 63 mg/dl, respectively. Lipoprotein electrophoresis, Ouchterlony double diffusion, and electron microscopy demonstrated that normal low density lipoproteins ...
P N, Herbert, J S, Hyams, D N, Bernier, M M, Berman, A L, Saritelli, K M, Lynch, A V, Nichols, T M, Forte   +7 more
openaire   +2 more sources

Rapid turnover of apolipoprotein C-III-containing triglyceride-rich lipoproteins contributing to the formation of LDL subfractionss⃞

Journal of Lipid Research, 2007
The atherogenicity theory for triglyceride-rich lipoproteins (TRLs; VLDL + intermediate density lipoprotein) generally cites the action of apolipoprotein C-III (apoC-III), a component of some TRLs, to retard their metabolism in plasma.
Zheng Chunyu, Khoo Christina, Ikewaki Katsunori, Frank M. Sacks   +3 more
doaj   +1 more source

High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins

Journal of Lipid Research, 2005
Efforts to elucidate the role of lipoprotein [a] (Lp[a]) in atherogenesis have been hampered by the lack of an animal model with high plasma Lp[a] levels.
Matthias Schneider, Joseph L. Witztum, Stephen G. Young, Erwin H. Ludwig, Elizabeth R. Miller, Sotirios Tsimikas, Linda K. Curtiss, Santica M. Marcovina, John M. Taylor, Richard M. Lawn, Thomas L. Innerarity, Robert E. Pitas   +11 more
doaj   +1 more source

Endogenous cholesterol synthesis is associated with VLDL-2 apoB-100 production in healthy humans

Journal of Lipid Research, 2003
Subjects with high plasma cholesterol levels exhibit a high production of VLDL apolipoprotein B-100 (apoB-100), suggesting that cholesterol is a mediator for VLDL production.
Berthil H.C.M.T. Prinsen, Johannes A. Romijn, Peter H. Bisschop, Martina M.J. de Barse, P.Hugh R. Barrett, Marie¨tte Ackermans, Ruud Berger, Ton J. Rabelink, Monique G.M. de Sain-van der Velden   +8 more
doaj   +1 more source

Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein. [PDF]

Journal of Clinical Investigation, 1981
In the two genetic forms of abetalipoproteinemia described previously, recessive abetalipoproteinemia and homozygous hypobetalipoproteinemia, all lipoproteins that normally contain apolipoprotein B are absent from plasma. We describe here a new disorder in which normal low density and very low density lipoproteins are absent, but in which triglycerides
M J, Malloy, J P, Kane, D A, Hardman, R L, Hamilton, K B, Dalal   +4 more
openaire   +2 more sources

Hepatic secretion of small lipoprotein particles in apobec-1−/− mice is regulated by the LDL receptor

Journal of Lipid Research, 2004
Recent studies have examined the role of the LDL receptor (LDLR) in regulating murine hepatic lipoprotein production and apolipoprotein B (apoB) secretion, with divergent conclusions from in vivo versus in vitro approaches.
Fatiha Nassir, Yan Xie, Bruce W. Patterson, Jianyang Luo, Nicholas O. Davidson   +4 more
doaj   +1 more source

Torpor: The Rise and Fall of 3-Monoiodothyronamine from Brain to Gut—From Gut to Brain?

Frontiers in Endocrinology, 2017
3-Monoiodothyronamine (T1AM), first isolated from rat brain, is reported to be an endogenous, rapidly acting metabolite of thyroxine. One of its numerous effects is the induction of a “torpor-like” state in experimental animals.
Hartmut H. Glossmann, Oliver M. D. Lutz
doaj   +1 more source

Identification of apolipoprotein B-100 low density lipoproteins, apolipoprotein B-48 remnants, and apolipoprotein E-rich high density lipoproteins in the mouse.

Journal of Lipid Research, 1994
Plasma lipoprotein fractions from inbred C57BL/6J mice and outbred ICR mice were prepared by sequential density ultracentrifugation using density ranges that were optimized for separating mouse lipoproteins, or by Superose 6 HR10/30 fast performance ...
H V de Silva, J Más-Oliva, J M Taylor, R W Mahley   +3 more
doaj   +1 more source

Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation

Journal of Lipid Research, 2004
Early radiokinetic studies revealed that the classical metabolic defect in patients with familial hypercholesterolemia (FH) is hypocatabolism of LDL due to decreased LDL receptor activity. However, recent studies have suggested that hepatic oversecretion
André J. Tremblay, Benoît Lamarche, Isabelle L. Ruel, Jean-Charles Hogue, Jean Bergeron, Claude Gagné, Patrick Couture   +6 more
doaj   +1 more source

Human apolipoprotein B-100 heparin-binding sites.

Journal of Biological Chemistry, 1987
Seven distinct heparin-binding sites have been demonstrated on human apolipoprotein (apo) B-100 by using a combination of digestion with cyanogen bromide or Staphylococcus aureus V-8 protease and heparin-Sepharose affinity chromatography. Based on fragment analysis, the approximate boundaries of the seven binding sites are as follows: site A, residues ...
K H, Weisgraber, S C, Rall
openaire   +2 more sources