Results 181 to 190 of about 381,163 (319)

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Associations between apolipoprotein B and bone mineral density: a population-based study. [PDF]

BMC Musculoskelet Disord, 2023
Zhao X, Tan N, Zhang Y, Xiao M, Li L, Ning Z, Liu M, Jin H.   +7 more
europepmc   +1 more source

Chicken Oocytes and Fibroblasts Express Different Apolipoproteins-B-Specific Receptors

, 1989
Kôzô Hayashi, Johannes Nimpf, Wolfgang J. Schneider   +2 more
openalex   +1 more source

The Surface-Exposed, Trypsin-Accessible Segments of Apolipoprotein B in the Low-Density Lipoprotein of Human Serum [PDF]

, 1982
M. John Chapman, Anne Millet, Dominique Lagrange, Sonia Goldstein, Y. Blouquit, C. Emlyn Taylaur, G.L. Mills   +6 more
openalex   +1 more source

Population pharmacokinetic‐pharmacodynamic analyses of amyloid positron emission tomography and plasma biomarkers for lecanemab in subjects with early Alzheimer's disease

CPT: Pharmacometrics &Systems Pharmacology, Volume 11, Issue 12, Page 1578-1591, December 2022., 2022
Abstract Lecanemab is a humanized immunoglobulin G1 monoclonal antibody that selectively binds to soluble Aβ aggregate species, while demonstrating low affinity for Aβ monomer. This article describes the population pharmacokinetic (PK) and PK/pharmacodynamic (PD) analyses for amyloid plaques, as measured using positron emission tomography (PET), and ...
Seiichi Hayato, Osamu Takenaka, Sree Harsha Sreerama Reddy, Ishani Landry, Larisa Reyderman, Akihiko Koyama, Chad Swanson, Sanae Yasuda, Ziad Hussein   +8 more
wiley   +1 more source

Oxidative events cause degradation of apoB-100 but not of apo[a] and facilitate enzymatic cleavage of both proteins

Journal of Lipid Research, 2001
Lipoprotein [a] (Lp[a]) contains equimolar amounts of apoB-100 and apolipoprotein [a] (apo[a]). Both proteins are amenable to degradation in vivo by mechanisms yet to be clearly defined.
Celina Edelstein, Kei Nakajima, Ditta Pfaffinger, Angelo M. Scanu   +3 more
doaj  

Is it time to measure apolipoprotein B? [PDF]

Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1990
A D Sniderman, J Silberberg
openaire   +3 more sources

Simultaneous quantification by double rocket immunoelectrophoresis of apolipoproteins A-I and B in blood spotted on filter paper. [PDF]

, 1988
S. Mičić, J. Arends, B Nørgaard‐Pedersen, Kirsten Christoffersen, G. E. ANDERSEN   +4 more
openalex   +1 more source

Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates

CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 62-73, January 2023., 2023
Abstract Despite considerable investment into potential therapeutic approaches for Alzheimer's disease (AD), currently approved treatment options are limited. Predictive modeling using quantitative systems pharmacology (QSP) can be used to guide the design of clinical trials in AD.
Vidya Ramakrishnan, Christina Friedrich, Colleen Witt, Robert Sheehan, Meghan Pryor, Jasvinder K. Atwal, Kristin Wildsmith, Katherine Kudrycki, Seung‐Hye Lee, Norman Mazer, Carsten Hofmann, Reina N. Fuji, Jin Y. Jin, Saroja Ramanujan, Michael Dolton, Angelica Quartino   +15 more
wiley   +1 more source

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Glia, EarlyView.
Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain. ABSTRACT Astrocytes are the most abundant glial cell type in the central nervous system (CNS).
Xiaoran Wei, Jiangtao Li, Michelle L. Olsen   +2 more
wiley   +1 more source