Results 161 to 170 of about 112,766 (266)

Greater Motor and Nonmotor Burden at Diagnosis Is Associated With Amyloid Copathology in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Concurrent Alzheimer's disease pathology is increasingly recognized as a poor prognostic factor in Parkinson's disease (PD), yet reliable clinical indicators for early identification of AD copathology remain poorly established.
Han Kyu Na   +11 more
wiley   +1 more source

Joint Risk Factor Combinations with Additive Interaction Increase the Risk of Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Combined effects of multiple risk factors on incident late‐onset Parkinson's disease (PD; LOPD) remain poorly characterized. Objective The objective of this study was to quantify the impact of joint risk exposures and estimate the contribution of potentially modifiable factors to incident LOPD risk.
Andrea Quattrone   +5 more
wiley   +1 more source

Serum elemental profile‐based machine learning models for Alzheimer's disease identification and cognitive score prediction

open access: yesNeuroprotection, EarlyView.
Serum elemental profiling combined with machine learning supports exploratory Alzheimer's disease (AD) identification and cognitive score prediction. In this retrospective cross‐sectional study, 874 participants from the BANC‐PUMC, including cognitively normal controls and patients with AD, were analyzed.
Haotian Liu   +6 more
wiley   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

open access: yesSmall, EarlyView.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

A Ferrous‐Supply‐Regenerating Lipid Nanoparticle Integrating RNAi Induces Ferroptosis for Cancer Therapy

open access: yesSmall, EarlyView.
ABSTRACT Targeting iron‐dependent ferroptosis with siRNA has emerged as a promising strategy for cancer treatment. The concept of ferrous‐supply regeneration, inspired by electro‐Fenton technology, has also gained interest as a non‐apoptotic approach to induce ferroptosis.
Dun Hu   +6 more
wiley   +1 more source

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