Results 251 to 260 of about 73,331 (301)

A neonatal case of apolipoprotein C-II deficiency

European Journal of Pediatrics, 1989
A neonatal case of apo C-II deficiency with hypertriglyceridaemia and xanthomas is presented. The patient responded well to a special diet formula containing medium-chain triglycerides (MCT). This is the first case of apo C-II deficiency to be discovered during the neonatal period.
M, Ohno, S, Ishibashi, K, Nakao, T, Nozue, K, Nonomura, N, Yamada, H, Aburatani, H, Shimano, T, Murase   +8 more
openaire   +2 more sources

Apolipoprotein C-II Deficiency Revisited

New England Journal of Medicine, 1984
In 1978, Breckenridge et al. described a patient with a deficiency of apolipoprotein C-II, the activator of the enzyme lipoprotein lipase.1 It was predicted that the newly discovered disorder would...
openaire   +2 more sources

Apolipoprotein C-II: the re-emergence of a forgotten factor

Current Opinion in Lipidology, 2020
Purpose of review Apolipoprotein C-II (apoC-II) is a critical cofactor for the activation of lipoprotein lipase (LPL), a plasma enzyme that hydrolyzes triglycerides (TG) on TG-rich lipoproteins (TRL). Although apoC-II was first discovered nearly 50 years ago, there is renewed interest in it because of the recent efforts to ...
Anna, Wolska, Mart, Reimund, Alan T, Remaley   +2 more
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Studies on an apolipoprotein C‐II variant occurring in Caucasians

ELECTROPHORESIS, 1992
AbstractApolipoproteins C (apo C‐II, apo C‐III0, apo C‐III1 and apo C‐III2) from delipidated very low density lipoproteins (VLDL) of 522 normo‐ and hyperlipoproteinemic Caucasians were screened by analytical isoelectric focusing. The immobilized pH gradient used was pH 4.0–5.0 with 7 M urea, which raised the apparent pH range to 4.8–5.7.
I, Menke-Möllers, J, Kurth, K, Oette
openaire   +2 more sources

The localization of the gene for apolipoprotein C-II to chromosome 19

Biochemical and Biophysical Research Communications, 1984
Human apolipoprotein (apo) C-II, a 79 amino acid protein, functions as a cofactor for lipoprotein lipase, the enzyme which catalyzes the hydrolysis of plasma triglycerides. The chromosomal location of apoC-II has been determined by filter hybridization analysis of human-mouse hybrid cells.
S S, Fojo, S W, Law, H B, Brewer, A Y, Sakaguchi, S L, Naylor   +4 more
openaire   +2 more sources

Apolipoprotein C-II is a novel substrate for matrix metalloproteinases

Biochemical and Biophysical Research Communications, 2006
We previously reported an efficient proteomic approach to identify matrix metalloproteinase (MMP) substrates from complex protein mixture. Using the proteomic approach, apolipoprotein C-II (apoC-II), which is a cofactor of lipoprotein lipase (LPL) and a component of very-low density lipoprotein and chylomicron, has been identified as a putative MMP-14 ...
Se Yeon, Kim, Sung Min, Park, Seung-Taek, Lee   +2 more
openaire   +2 more sources

Inheritance of Apolipoprotein C-II Deficiency with Hypertriglyceridemia and Pancreatitis

New England Journal of Medicine, 1978
A study of the relatives of a patient with apolipoprotein C-II deficiency showed that the defect is inherited as an autosomal recessive trait. The kindred studied originated from an isolated population in which considerable inbreeding has occurred for 140 years.
D W, Cox, W C, Breckenridge, J A, Little
openaire   +2 more sources

Apolipoprotein C-II and C-III levels in hyperlipoproteinemia

Metabolism, 1979
Abstract Apoprotein C-II (ApoC-II) functions as a modulator of the hydrolysis of lipoprotein triglycerides by increasing the activity of lipoprotein lipase. Apoprotein C-III (ApoC-III) appears to have an inhibitory effect on ApoC-II-stimulated hydrolysis.
G, Schonfeld, P K, George, J, Miller, P, Reilly, J, Witztum   +4 more
openaire   +2 more sources

Apolipoproteins C-II and C-III in Peripheral Arterial Disease

Angiology, 1994
Apolipoprotein (apo) C-II and apo C-III serum concentrations were investi gated in 119 normotriglyceridemic male subjects with peripheral arterial dis ease (PAD) or coronary heart disease (CHD) or without clinical manifestations of atherosclerotic disease. All subjects included in the study had similar blood levels of total cholesterol ( < 400 mg/dL)
ALESSANDRI, Cesare, BASILI, Stefania, M. Maurelli, Andreozzi, Paola, A. Colletta, M. Paradiso, CORDOVA, Corrado   +6 more
openaire   +3 more sources

Genetic Variation in the Apolipoproteins C-II and C-III

1988
The C group apolipoproteins are primarily associated with triglyceriderich lipoprotein particles (1). They are important in triglyceride metabolism where they act as allosteric affectors of lipoprotein lipase. Apolipoprotein C-II is an activator of lipoprotein lipase while C-III is an inhibitor of both lipoprotein lipase and hepatic lipase ...
R E, Ferrell, M I, Kamboh, B S, Sepehrnia, L L, Adams-Campbell, K M, Weiss   +4 more
openaire   +2 more sources