Results 241 to 250 of about 73,331 (301)

Digital Sleep-Wake Cycle Metrics and Dementia Prediction in Older Adults.

JAMA Neurol
Cavaillès C, Danilevicz IM, Vidil S, Fayosse A, Chen M, van Hees V, Kivimäki M, Dugravot A, Singh-Manoux A, Sabia S.   +9 more
europepmc   +1 more source

Visualization of polymorphism in apolipoprotein C-II amyloid fibrils

Journal of Biochemistry, 2010
The misfolding and self-assembly of proteins into amyloid fibrils, which occur in several debilitating and age-related diseases, are affected by common components of amyloid deposits, notably lipids and lipid complexes. Previously, the effects of phospholipids on amyloid fibril formation by apolipoprotein (apo) C-II have been examined, where low ...
Chai L, Teoh, Hisashi, Yagi, Michael D W, Griffin, Yuji, Goto, Geoffrey J, Howlett   +4 more
openaire   +3 more sources

Apolipoprotein C‐II deficiency presenting as a lipid encephalopathy in infancy

Annals of Neurology, 2003
AbstractAn infant presented with massive hyperchylomicronemia and a severe encephalopathy. MRI showed marked lipid deposition throughout the brain. Despite the normalization of the biochemistry, there was little clinical improvement, and at 18 months of age she has severe developmental delay, a strikingly abnormal MRI.
CJ WILSON, CP OLIVA, F. MAGGI, AL CATAPANO, CALANDRA BUONAURA, Sebastiano   +4 more
openaire   +3 more sources

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Apolipoprotein C-II Deficiency

1986
The lipolysis of chylomicrons and very low density lipoproteins is responsible for the delivery of energy in the form of fatty acids to adipose or muscle tissue. The fatty acids are transported in the form of triacylglycerols in these lipoproteins following their synthesis in the intestine or liver.
A. L. Catapano, A. Capurso
openaire   +3 more sources

Apolipoprotein C-II deficiency associated with nonfunctional mutant forms of apolipoprotein C-II

Canadian Journal of Biochemistry and Cell Biology, 1984
Two previously unidentified apolipoproteins (apo) designated apo C-II-X and C-II-Y have been found in plasma of homozygotes and obligate heterozygotes of a family with apo C-II deficiency. Because the plasmas of homozygotes do not activate lipoprotein lipase, apo C-II-X and C-II-Y are apparently nonfunctional.
G F, Maguire, J A, Little, G, Kakis, W C, Breckenridge   +3 more
openaire   +2 more sources

Electrophoretic screening for human apolipoprotein C-II variants: repeated identification of apolipoprotein C-II(K19T)

Journal of Molecular Medicine, 1995
Screening for apolipoprotein (apo) C-II variants in the plasma of 400 students, 600 patients of a cardiological rehabilitation center, and 1200 patients of an outpatient lipid clinic by isoelectric focusing and subsequent anti-apo C-II immunoblotting led to the identification of four individuals whose plasma samples contained an apo C-II isoform with ...
H, Wiebusch, J R, Nofer, A, von Eckardstein, H, Funke, U, Wahrburg, H, Martin, E, Köhler, G, Assmann   +7 more
openaire   +2 more sources

Hypertriglyceridemia Associated with Deficiency of Apolipoprotein C-II

New England Journal of Medicine, 1978
A 59-year-old man with severe hypertriglyceridemia and no post-heparin lipolytic activity was studied because of a marked fall in plasma triglyceride concentrations after a blood transfusion. An apolipoprotein activator (apolipoprotein C-II) for lipoprotein lipase could not be detected by polyacrylamide-gel electrophoresis of apoproteins ...
W C, Breckenridge, J A, Little, G, Steiner, A, Chow, M, Poapst   +4 more
openaire   +2 more sources