Results 41 to 50 of about 73,331 (301)

Correlation between mesenteric fat thickness and serum apolipoproteins in patients with peripheral arterial occlusive disease

Lipids in Health and Disease, 2012
Background Visceral fat possesses the most detrimental potential for cardiovascular morbidity through the release of adipokines, as well as metabolic and proinflammatory mediators, which adversely affect metabolic and vascular homeostasis.
Perelas Apostolos, Safarika Vanessa, Vlachos Ioannis S, Tzanetakou Irene, Korou Laskarina-Maria, Konstantopoulos Panagiotis, Doulamis Ilias, Ioannidis Ioannis, Kornezos Ioannis, Gargas Dimitrios, Klonaris Christos, Perrea Despina N, Chatziioannou Achilleas   +12 more
doaj   +1 more source

Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E

, 2010
It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors ...
Kirkwood Thomas B. L., Drenos Fotios, Drenos, F, Kirkwood, TBL, Fotios Drenos, Thomas B L Kirkwood   +5 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

High density lipoproteins bind Aβ and apolipoprotein C-II amyloid fibrils

Journal of Lipid Research, 2006
Disease-associated amyloid deposits contain both fibrillar and nonfibrillar components. The majority of these amyloid components originate or coexist in the bloodstream.
Leanne M. Wilson, Chi L.L. Pham, Alicia J. Jenkins, John D. Wade, Andrew F. Hill, Matthew A. Perugini, Geoffrey J. Howlett   +6 more
doaj   +1 more source

APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample

, 2010
The literature on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP) remains inconsistent, mainly due to low statistical power of previous studies.
Pikhart, H., Peasey, Anne, Pikhart, Hynek, Stavek, Petr, Hubacek, J.A., Kubinova, R., Marmot, Michael, Kubinova, Ruzena, Peasey, A., Hubacek, Jaroslav A., Marmot, M., Stavek, P., Bobak, Martin, Bobak, M.   +13 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

ESR1 polymorphism is associated with plasma lipid and apolipoprotein levels in Caucasians of the Rochester Family Heart Study*s⃞

Journal of Lipid Research, 2008
We evaluated six estrogen receptor 1 (ESR1) polymorphisms for association with ten plasma lipid and apolipoprotein traits in 1,847 individuals (941 females and 906 males) in the multi-generation Rochester Family Heart Study using a generalized estimating
Kathy L.E. Klos, Eric Boerwinkle, Robert E. Ferrell, Stephen T. Turner, Alanna C. Morrison   +4 more
doaj   +1 more source

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

Nutrition & Metabolism, 2020
Background Early diagnosis of type 2 diabetes mellitus (T2DM) is still difficult. Screening of plasma biomarkers has great significance of optimizing diagnosis and predicting the complications of T2DM.
Shuai Wang, Zhiyuan Lu, Yuxin Wang, Tianran Zhang, Xiaodong He   +4 more
doaj   +1 more source

The Association between Apolipoprotein A-II and Metabolic Syndrome in Korean Adults: A Comparison Study of Apolipoprotein A-I and Apolipoprotein B [PDF]

Diabetes & Metabolism Journal, 2012
BackgroundApolipoprotein A-II (apoA-II) is the second-most abundant apolipoprotein in human high-density lipoprotein and its role in cardio metabolic risk is not entirely clear.
Dong Won Yi, Dong Wook Jeong, Sang Yeoup Lee, Seok Man Son, Yang Ho Kang   +4 more
doaj   +1 more source