Results 131 to 140 of about 20,685,408 (374)

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

INFLUENCE OF APOE GENOTYPES ON BIOCHEMICAL INDICES OF IRON AND LIPID METABOLISM IN PATIENTS WITH THE ENDOMETRIUM NEOPLASTIC DISEASES AND HEAL THY WOMEN

Исследования и практика в медицине, 2015
Objective. APOE genotype association with the level of iron in plasma and the risk of endometrial neoplastic diseases has not been studied. The aim of the work was to analyze the genotypic associations of the apolipoprotein E (APOE) with iron and lipid ...
T. A. Ivanova, M. V. Poluektova, V. A. Khorokhorina, O. A. Vorob’eva, T. V. Chirkova, L. S. Mkrtchyan, N. I. Sychenkova, L. I. Krikunova, N. I. Ryabchenko   +8 more
doaj   +1 more source

Angiotensin II Receptor Blocker Reduces Oxidative Stress and Attenuates Hypoxia-Induced Left Ventricular Remodeling in Apolipoprotein E-Knockout Mice [PDF]

, 2007
Chika Yamashita, Tetsuya Hayashi, Tatsuhiko Mori, Naoko Tazawa, Chol-Jun Kwak, Daisuke Nakano, Koichi Sohmiya, Yoshikatsu Okada, Yasushi Kitaura, Yasuo Matsumura   +9 more
openalex   +1 more source

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)*

Journal of Biological Chemistry, 2015
Background: TREM2 is associated with several neurodegenerative diseases. Results: ApoE bound to TREM2 and increased phagocytosis of apoptotic neurons by microglia.
Y. Atagi, Chia-Chen Liu, Meghan Painter, Xiao-Fen Chen, Christophe Verbeeck, Honghua Zheng, Xia Li, R. Rademakers, Silvia S Kang, Huaxi Xu, S. Younkin, Pritam Das, J. Fryer, G. Bu   +13 more
semanticscholar   +1 more source

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles

Annals of Neurology, EarlyView.
Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson   +5 more
wiley   +1 more source

Association of Apolipoprotein E Gene Polymorphism with Type 2 Diabetic Nephropathy in the Southern Chinese Population

International Journal of General Medicine, 2023
Caiyan Gan,1– 3 Yinmei Zhang,1– 3 Xianyan Zhang,4 Qionghui Huang,1– 3 Xuemin Guo1– 4 1Research Experimental Center, Meizhou People’s Hospital, Meizhou, People’s Republic of China; 2Guangdong Engineering Technological Research Center of Clinical Molecular
Gan C, Zhang Y, Zhang X, Huang Q, Guo X
doaj  

Apolipoprotein E gene polymorphism and renal function are associated with apolipoprotein E concentration in patients with chronic kidney disease

Lipids in Health and Disease, 2019
Background Chronic kidney disease (CKD) associates with complex lipoprotein disturbances resulting in high cardiovascular risk. Apolipoprotein E (APOE) is a polymorphic protein with three common isoforms (E2; E3; E4) that plays a crucial role in ...
Monika Czaplińska, Agnieszka Ćwiklińska, Monika Sakowicz-Burkiewicz, Ewa Wieczorek, Agnieszka Kuchta, Robert Kowalski, Barbara Kortas-Stempak, Alicja Dębska-Ślizień, Maciej Jankowski, Ewa Król   +9 more
doaj   +1 more source

When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ‐PET Centiloid 15, Mean Age of 66 Years

Annals of Neurology, EarlyView.
Objective Sporadic late‐onset Alzheimer's disease (AD) is characterized by a long pre‐clinical phase where amyloid‐beta (Aβ) and tau begin to accumulate in the brain. The primary objective was to determine the age at which AD starts by finding the average population age when both positron emission tomography (PET) Aβ (Aβ‐PET) and plasma Aβ42/40 become ...
Rodrigo Cánovas, Timothy Cox, Vincent Doré, Pierrick Bourgeat, Jurgen Fripp, Azadeh Feizpour, Rosita Shishegar, Christopher J. Fowler, Simon M. Laws, Tenielle Porter, Stephanie Rainey‐Smith, Leslie M. Shaw, Randall J. Bateman, Yan Li, Ovod Vitaliy, Michael W. Weiner, John C. Morris, Tammie L.S. Benzinger, Suzanne E. Schindler, Akinori Nakamura, Takeshi Iwatsubo, Takeshi Ikeuchi, Takashi Kato, Paul Maruff, Hamid R. Sohrabi, Christopher C. Rowe, Ralph N. Martins, Colin L. Masters, James D. Doecke, for the Alzheimer's Disease Neuroimaging Initiative   +29 more
wiley   +1 more source

Effect of Apolipoprotein E ϵ4 Allele on the Progression of Carotid Atherosclerosis Through Apolipoprotein Levels

Pharmacogenomics and Personalized Medicine, 2022
Wenbing Ma,1,2,* Liting Zhang,1,* Lei Luo,1 Suya Zhang,1,* Shuang Yang,1 Hongping Yao,1 Lei Zhang,1 Xiaoyun Lu,2 Weiyi Feng1 1Department of Pharmacology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061 ...
Ma W, Zhang L, Luo L, Zhang S, Yang S, Yao H, Zhang L, Lu X, Feng W   +8 more
doaj  

Membranous Nephropathy-Like Apolipoprotein E Deposition Disease with Apolipoprotein E Toyonaka (Ser197Cys) and a Homozygous Apolipoprotein E2/2

Case Reports in Nephrology and Dialysis, 2018
A 20-year-old female student underwent renal biopsy because of chance proteinuria and hematuria. Histological study revealed a membranous nephropathy-like appearance by light microscopy. But immunoglobulins and complements were negative in the glomerulus
Megumu Fukunaga, Kiyotaka Nagahama, Michiko Aoki, Akira Shimizu, Shigeo Hara, Akira Matsunaga, Eri Muso, Takao Saito   +7 more
doaj   +1 more source