Results 151 to 160 of about 103,941 (262)

Apolipoprotein E and Alzheimer's disease pathology in a diverse autopsy study. [PDF]

Alzheimers Dement
Suemoto CK, Paradela R, Leite REP, Paes VR, Pasqualucci CA, Ferriolli E, Zatz M, do Nascimento Santos G, de Alexandria MALS, Pereira AC, Fortea J, Naslavsky M, Grinberg LT.   +12 more
europepmc   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, EarlyView.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

A Ferrous‐Supply‐Regenerating Lipid Nanoparticle Integrating RNAi Induces Ferroptosis for Cancer Therapy

Small, EarlyView.
ABSTRACT Targeting iron‐dependent ferroptosis with siRNA has emerged as a promising strategy for cancer treatment. The concept of ferrous‐supply regeneration, inspired by electro‐Fenton technology, has also gained interest as a non‐apoptotic approach to induce ferroptosis.
Dun Hu, Yun‐Hua Xu, Dan Peng, Qi Tan, Jun‐Lin Jiang, Sheng‐Dan Nie, Shan Wang   +6 more
wiley   +1 more source

Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing. [PDF]

Bone Res
Huang M, Balu AR, Molitoris KH, Bareja A, Baht GS.   +4 more
europepmc   +1 more source

Fractionation‐Free Protein Corona Quantification Through Synchrotron‐Based Small‐Angle X‐ray Scattering

Small Methods, EarlyView.
A fractionation‐free SAXS approach quantifies protein corona formation on silica nanoparticles under native conditions. By deconvoluting scattering from free and bound proteins, adsorbed mass is directly determined in simple and complex media. The method resolves adsorption regimes and thermodynamics, establishing non‐invasive, in situ characterization
Juliana T. T. Carvalho, Caroline E. P. Silva, Lindomar J. C. Albuquerque, Antônio A. Malfatti‐Gasperini, Liming Wang, Nathan P. Cowieson, Mateus B. Cardoso   +6 more
wiley   +1 more source

Conformational features of guinea pig apolipoprotein E offer insights into functioning of human apolipoprotein E. [PDF]

Arch Biochem Biophys
Reddick I, Celis G, Pal S, Nguyen JT, Saraswathi D, Garai K, Narayanaswami V.   +6 more
europepmc   +1 more source

Spatial Characterization of the Human Meniscus: Bridging Biomechanics and Biochemistry Using Atomic Force Microscopy Micro‐Indentation and Mass Spectrometry Imaging

Small Methods, EarlyView.
A multimodal imaging approach combines AFM micro‐indentation and MALDI mass spectrometry imaging on the same fresh‐frozen human meniscus section to directly associate microscale mechanics with molecular composition. Collagen‐rich regions exhibit increased stiffness, whereas zones enriched in other extracellular matrix proteins are mechanically less ...
Aleksandra N. Lebedeva, Martin Handelshauser, Orestis G. Andriotis, Lena Hirtler, Martina Marchetti‐Deschmann, Philipp J. Thurner   +5 more
wiley   +1 more source

Apolipoprotein E (APOE) regulates the transport of monosialotetrahexosylganglioside (GM1). [PDF]

J Biol Chem
Zhang DY, Wang J, Huang G, Dokholyan M, Willcox S, Griffith J, Ding F, Dokholyan NV.   +7 more
europepmc   +1 more source

Hormone Replacement Therapy for Menopausal Symptoms and the Risk of Cardiometabolic Disease: Current Evidence and Future Directions

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background The transition through menopause is accompanied by a series of adverse metabolic changes which are associated with an increased risk of cardiometabolic disease, a major cause of mortality in women after midlife. Whilst the indication for menopausal hormone replacement therapy (HRT) is the control of menopausal symptoms ...
Jiawen Dong, Sarah Hillman, Sharon Dixon, Anupa Shah, Radha Venkatakrishnan, Jeremy W. Tomlinson   +5 more
wiley   +1 more source