Results 271 to 280 of about 207,429 (294)

Long‐term effects of a multidomain intervention on cognitive function and metabolic control in older adults with type 2 diabetes and mild cognitive impairment: A 42‐month follow‐up of the J‐MIND‐Diabetes study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This study investigated the long‐term effects of a multidomain intervention on cognition and metabolic control in patients with type 2 diabetes and mild cognitive impairment (MCI). Materials and methods Outpatients aged 70–85 years were randomized to an 18‐month multidomain intervention (comprising metabolic/vascular risk management ...
Taiki Sugimoto, Takuya Omura, Atsushi Araki, Chie Haneda, Keiko Honda, Minoru Kishi, Toshimasa Takahashi, Kenji Toyoshima, Suguru Tsuume, Kazuaki Uchida, Hisashi Noma, Ayaka Onoyama, Yoko Yokoyama, Mio Shinozaki, Paul K. Crane, Takashi Sakurai, J‐MIND‐Diabetes Study Group   +16 more
wiley   +1 more source

Fueling the brain - the role of apolipoprotein E in brain energy metabolism and its implications for Alzheimer's disease. [PDF]

Transl Psychiatry
Budny V, Ruminot I, Wybitul M, Treyer V, Barros LF, Tackenberg C.   +5 more
europepmc   +1 more source

D-4F Does Not Mitigate Key Parameters in Rat Model of Severe Pulmonary Hypertension [PDF]

, 2007
Baumgardt, Shelley, Molthen, Robert C., Pritchard, K. A., Jr   +2 more
core   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

Apolipoprotein E ε4 homozygosity exacerbates retinal and cerebral microvascular dysfunction in Alzheimer's disease: A mediation analysis of vascular contributions to cognitive decline. [PDF]

Alzheimers Dement
Liu Y, Zhu H, Wang Y, Luan X, Chen J, Qian J, Shen J, Liu Y, Wen C, Cao L, Tang B, Ko H, Kwapong WR, Wang Z.   +13 more
europepmc   +1 more source

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, EarlyView.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Plasma apolipoprotein E and monocyte chemoattractant protein-1 levels in young people with HIV and ischemic stroke in Lusaka, Zambia. [PDF]

Front Stroke
Zimba S, Ngalamika O, Mukambo E, Chisha M, Kayamba V, Mulenga L, Siddiqi O, Saylor D, Ross OA, Atadzhanov M.   +9 more
europepmc   +1 more source

Extracellular vesicle proteomics identifies novel blood biomarkers for the early diagnosis of status epilepticus

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to identify novel blood‐based biomarkers associated with the early diagnosis of status epilepticus (SE) by exploring proteomic alterations in plasma extracellular vesicles (EVs). Methods We conducted an observational and prospective study in a two‐phase design: a discovery proteomic analysis of plasma EVs ...
Estevo Santamarina, Laura Abraira, Daniel Campos‐Fernández, Manuel Quintana, Elena Fonseca, Samuel López‐Maza, Sofía Lallana, Anna Penalba, Anna Rosell, Júlia Valor‐Blanquer, Clara Sanz, Manuel Toledo   +11 more
wiley   +1 more source