Results 251 to 260 of about 196,159 (307)
Some of the next articles are maybe not open access.
Apolipoprotein E and Atherosclerosis
Current Atherosclerosis Reports, 2021The functions, genetic variations and impact of apolipoprotein E on lipoprotein metabolism in general are placed in the context of clinical practice dealing with moderate dyslipidaemia as well as dysbetalipoproteinemia, a highly atherogenic disorder and lipoprotein glomerulopathy.Additional variants of apolipoprotein E and participation of ...
openaire +2 more sources
Neurology, 1995
To the Editor: We made three major points in our paper [1] published in the August 1994 issue of Neurology. First, we found that two of 28 cognitively normal people over the age of 90 had inherited the apolipoprotein E (ApoE) epsilon4 allele (see table 1 in reference 1). This suggests that it is possible to …
G W, Rebeck, B T, Hyman
openaire +2 more sources
To the Editor: We made three major points in our paper [1] published in the August 1994 issue of Neurology. First, we found that two of 28 cognitively normal people over the age of 90 had inherited the apolipoprotein E (ApoE) epsilon4 allele (see table 1 in reference 1). This suggests that it is possible to …
G W, Rebeck, B T, Hyman
openaire +2 more sources
Apolipoprotein E and atherosclerosis
Current Opinion in Lipidology, 2000Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants.
L K, Curtiss, W A, Boisvert
openaire +2 more sources
Apolipoprotein E in Hyperlipidemia
Annals of Internal Medicine, 1994To review DNA analysis of apolipoprotein E used to assess patients with hyperlipidemia.44 basic science studies of molecular analysis; 42 basic science studies of the biochemical, cellular biological, and molecular biological features of apolipoprotein E; and 29 clinical investigational studies, meta-analyses, and case series of patients with mutations
C C, Walden, R A, Hegele
openaire +2 more sources
Genotyping of Apolipoprotein E
2003Apolipoprotein E (apo E) is a 299-amino acid plasma protein involved in cholesterol transport and is found in chylomicrons, very low density lipopro-tein, intermediate-density lipoprotein, and high-density lipoprotein (1,1).
I C, Ozturk, N, Akel, A A, Killeen
openaire +2 more sources
Current Opinion in Neurology, 1996
Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared.
openaire +2 more sources
Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared.
openaire +2 more sources
Apolipoprotein in E in Myasthenia Gravis
Annals of the New York Academy of Sciences, 1998It is believed that apo E may moderate T lymphocytes by activation of mitogens or antigens. In that way, it has an influence on immune processes and it is reasonable to study the relationship between apo E genotypes and myasthenia gravis phenotypes. We tried to find any feature connected to the development of a different intensity of myasthenia gravis.
Šoštarko, Marija +5 more
openaire +4 more sources
2013
For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter ...
Carrasquillo, Minerva M. +2 more
openaire +2 more sources
For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter ...
Carrasquillo, Minerva M. +2 more
openaire +2 more sources
Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease
Ageing Research Reviews, 2009The genetic epidemiology of sporadic Alzheimer's disease (SAD) remains a very active area of research,making it one of the most prolifically published areas in medicine and biology. Numerous putative candidate genes have been proposed. However, with the exception of apolipoprotein E (APOE), the only confirmed genetic risk factor for SAD, all the other ...
SERIPA D +6 more
openaire +2 more sources
Apolipoprotein E polymorphism and gallstones
Gastroenterology, 1996Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by increasing hepatic and biliary cholesterol ...
A, Bertomeu +9 more
openaire +2 more sources