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Activated astrocytes drive the accumulation of apolipoprotein E at the brain tumor edge. [PDF]

Brain Tumor Pathol
Chien TY, Chiang CS.
europepmc   +1 more source

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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

Lipids and Lipid Metabolism, 1987
We have previously demonstrated that astrocytes synthesize and secrete apolipoprotein E in situ. In the present work, primary cultures of rat brain astrocytes were used to study apolipoprotein E synthesis, secretion, and metabolism in vitro. The astrocytes in culture contained immunoreactive apolipoprotein E in the area of the Golgi apparatus ...
R E Pitas, J K Boyles, R W Mahley
exaly   +3 more sources

Apolipoprotein E and the Apolipoprotein E-Deficient Mouse

Annual Review of Nutrition, 1995
Apolipoprotein E (apoE) is one of several lipoprotein transfer genes. A primary function of this protein is the mediation of receptor-mediated lipoprotein removal from the blood. Several studies have demonstrated that genetic variation at the apoE locus is associated with an increased risk of developing atherosclerosis, and recent studies implicate ...
A S, Plump, J L, Breslow
openaire   +3 more sources