Results 31 to 40 of about 334,081 (324)
Alzheimer Disease is Associated with Isotropic Ocular Enlargement [PDF]
arXiv, 2023 Recent studies have documented ocular changes in dementia patients, especially Alzheimer Disease (AD). In this study, we explored the change of eye size and eye shape in dementia, including AD patients. The eyeball volume and diameters were estimated via T1-weighted brain magnetic resonance (MR) images in the OASIS-3 database which included 83 AD, 247 ...
arxiv
Chromosomal breaks at the origin of small tandem DNA duplications
BioEssays, Volume 45, Issue 1, January 2023., 2023 Small tandem DNA duplications form a specific mutational signature frequently found in human disease alleles and cancer genes. Here we hypothesize that these duplications mainly arise at chromosomal DNA breaks that result from two closely located single‐stranded nicks, through error‐prone repair by the non‐homologous end‐joining pathway. Abstract Small
Joost Schimmel +3 more
wiley +1 more source
Evidence of emerging BBB changes in mid‐age apolipoprotein E epsilon‐4 carriers
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 This study demonstrated a tendency towards BBB permeability in APOEε4 participants emerging from mid‐age, with quantitative differences observable on a number of the measures. Results from this study may help identify at‐risk populations at an early stage which will be crucial in facilitating the development of early interventions to change the ...
Nourah M. Alruwais +3 more
wiley +1 more source
International Journal of General Medicine, 2021 Rabia Latif,1 Nazish Rafique,1 Lubna Al Asoom,1 Ahmed A Alsunni,1 Ayad Mohammed Salem,1 Dinah Abdulhadi AlNoaimi,2 Wasan Mohammed AlHarbi,2 Ahad Yasir Shaikh,2 Shoug Abdullah AlRaddadi,2 Leena Abdulrahman AlMuhaish,2 Dana Almohazey,3 Sayed Abdulazeez,4 J
Latif R +12 more
doaj
Accounting for iron-related off-target binding effects of 18F-AV1451 PET in the evaluation of cognition and microstructure in APOE-e4+ MCI [PDF]
arXiv, 2022 The pathology of Alzheimer's disease (AD) and mild cognitive impairment (MCI) is characterized by the presence of beta-amyloid extracellular plaques and neurofibrillary tangles containing hyper-phosphorylated tau. Individuals carrying the apolipoprotein E-e4 (APOE-e4) allele are at increased risk of cognitive decline and developing AD pathology.
arxiv
Molecular Dynamics Simulation of Apolipoprotein E3 Lipid Nanodiscs [PDF]
arXiv, 2023 Nanodiscs are binary discoidal complexes of a phospholipid bilayer circumscribed by belt-like helical scaffold proteins. Using coarse-grained and all-atom molecular dynamics simulations, we explore the stability, size, and structure of nanodiscs formed between the N-terminal domain of apolipoprotein E3 (apoE3-NT) and variable number of 1,2-dimyristoyl ...
arxiv
An extension of a theorem of Zermelo [PDF]
Bull. symb. log 25 (2019) 208-212, 2018 We show that if (M,E,E') satisfies the first order Zermelo-Fraenkel axioms of set theory when the membership relation is E and also when the membership relation is E', and in both cases the formulas are allowed to contain both E and E', then (M,E) and (M,E') are isomorphic, and the isomorphism is definable in (M,E,E').
arxiv +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Lipid metabolism in pancreatic cancer: emerging roles and potential targets
Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022 Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source