Results 161 to 170 of about 45,778 (202)

The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in a sample of unrelated individuals

American Journal of Medical Genetics, 1987
AbstractRecent advances in molecular biology provide measures of genotypes at loci involved in lipid metabolism. Genotypes for apolipoprotein E (apo E) and quantitative levels of total plasma cholesterol, betalipoprotein, and triglycerides were measured in a sample of 223 unrelated individuals from Nancy, France.
Eric Boerwinkle, Sophia Visvikis, Dorothy Welsh, Josiane Steinmetz, Samir M. Hanash, Charles F. Sing, John M. Opitz, James F. Reynolds   +7 more
openaire   +2 more sources

An analysis of genotype effects and their interactions by using the apolipoprotein E polymorphism and longitudinal data.

American journal of human genetics, 1989
We investigate the interaction between the apolipoprotein E polymorphism and changes in weight and height as they affect the longitudinal profile of total cholesterol, triglyceride, beta lipoprotein, and glucose levels. Data were available on a sample of 466 individuals in 158 nuclear families from Nancy, France. Longitudinal data analyses were carried
R, Gueguen, S, Visvikis, J, Steinmetz, G, Siest, E, Boerwinkle   +4 more
openaire   +1 more source

Association of apolipoprotein E polymorphism with lipoprotein glomerulopathy. Report of 2 cases with a new genotype and comparison of the relative frequencies of apolipoprotein E isoforms in lipoprotein glomerulopathy and in the general population.

Nephron, 1998
Two cases of lipoprotein glomerulopathy with a new apolipoprotein E (Apo E) genotype, epsilon3/epsilon4, were diagnosed recently. These 2 cases, together with other cases documented in English literature made a total of 6 common isoforms of Apo E encountered in lipoprotein glomerulopathy.
A H, Yang, Y Y, Ng, D C, Tarng, J Y, Chen, M S, Shiao, J T, Kao   +5 more
openaire   +1 more source

Rapid detection of apolipoprotein E genotypes in Alzheimer's disease using polymerase chain reaction-single strand conformation polymorphism.

The Southeast Asian journal of tropical medicine and public health, 2007
Apolipoprotein E (APOE) gene on chromosome 19q13.2 is encoded by three common alleles designated as epsilon2, epsilon3 and epsilon4. In Alzheimer's disease (AD) the epsilon4 allele is over-represented and is considered to be a major genetic risk factor. Several methods have been developed to determine APOE genotypes.
Worawan, Kamruecha, Sirintorn, Chansirikarnjana, Ekapot, Nimkulrat, Chesda, Udommongkol, Wanna, Wongmek, Wipawan, Thangnipon   +5 more
openaire   +1 more source

The use of measured genotype information in the analysis of quantitative phenotypes in man. III. Simultaneous estimation of the frequencies and effects of the apolipoprotein E polymorphism and residual polygenetic effects on cholesterol, betalipoprotein and triglyceride levels.

Annals of human genetics, 1987
We have begun a measured genotype approach to the genetic analysis of lipid and lipoprotein variability. This approach enables one to simultaneously estimate the frequencies and effects of alleles at specific loci along with the residual polygenetic variance component.
E, Boerwinkle, C F, Sing
openaire   +1 more source

Apolipoprotein E Genotype and Concussion in College Athletes

Clinical Journal of Sports Medicine, 2010
R. Tierney, J. Mansell, M. Higgins, J. McDevitt, Nieka Toone, J. Gaughan, A. Mishra, Evgeny Krynetskiy   +7 more
semanticscholar   +1 more source

Apolipoprotein E genotype and warfarin dosing among Caucasians and African Americans

The Pharmacogenomics Journal, 2008
S. Kimmel, Jason D. Christie, C. Kealey, Zhen Chen, M. Price, C. Thorn, Colleen M. Brensinger, Craig W. Newcomb, Alexander S. Whitehead   +8 more
semanticscholar   +1 more source

APOLIPOPROTEIN E-GENOTYPING AND MRI STUDY FOR CLASSIFYING ALZHEIMER'S DISEASE USING POLYMERASE CHAIN REACTION–RESTRICTION FRAGMENT LENGTH POLYMORPHISM (PCR-RFLP) AND THE RESTRICTED ENZYMES AFⅢ FOR RS429358 AND HAEⅡ FOR RS7412 TECHNIQUE: BASIC PROTOCOL AND OPTIMIZATION STRATEGIES

Journal of Medical Imaging and Radiation Sciences, 2023
Mohad Azmi Nur Hafizah, Suppiah Subapriya, Ibrahim Nur Shahidatul Nabila, Ibrahim Buhari, Seriramulu Vengkatha Priya, Mohamad Amin Amrina, Mohamad Mazlyfarina, Karuppiah Thilakavathy, Omar Nur Farhayu, Abu Hassan Hasyma, Ibrahim Normala, Razali Rizah Mazzuin, Harrun Noor Harzana, Sallehuddin Hakimah, Saripan M Iqbal   +14 more
openaire   +1 more source

Immunocytochemical and genotypic polymorphism of apolipoprotein E in senile dementias of the AD and non-AD types

Neurobiology of Aging, 1994
Y. Robitaille, C. Bétard, A. Laroche-Cholette, D. Gauvreau, M. Gee, P. Roy, R.W. Milne   +6 more
openaire   +1 more source

Apolipoprotein E genotype does not influence the progression of multiple sclerosis

Journal of Neurology, 2003
G. Savettieri, V. Andreoli, S. Bonavita, R. Cittadella, C. Caltagirone, M. C. Fazio, P. Girlanda, Francesco Pira, M. Liguori, G. Logroscino, A. Lugaresi, U. Nocentini, A. Reggio, G. Salemi, P. Serra, G. Tedeschi, L. Toma, M. Trojano, P. Valentino, A. Quattrone   +19 more
semanticscholar   +1 more source