Results 111 to 120 of about 40,273 (244)

GREM1 deficiency induced bone marrow adipose niche promotes B‐cell acute lymphoblastic leukemia disease progression

International Journal of Cancer, EarlyView.
What's New? Too often, children treated for B‐cell acute lymphocytic leukemia (B‐ALL) experience relapse. Here, the authors investigate the role of dyslipidemia in leukemia progression. Higher adipogenicity in bone marrow mesenchymal stem cells, and increased triglyceride accumulation, are associated with higher risk of death.
Lili Song, Rui Zhang, Liya Pan, Qiang Mi, Yi Yang, Xiang Wang, Yani Ma, Shuhong Shen, Benshang Li, Yanxin Li, Li Hong   +10 more
wiley   +1 more source

Sex‐specific associations of Roseburia with uric acid metabolism and hyperuricemia risk in females

iMetaOmics, EarlyView.
Researchers recruited 623 participants, including 270 females, and used 16S rDNA sequencing to investigate gender differences in hyperuricemia. In healthy females, Roseburia was enriched, positively correlating with estrogen and negatively with uric acid, suggesting it is a potential biomarker affecting uric acid levels in females.
Zhihan Yang, Zeng Zhang, Mohan Chen, Jin Hu, Yingqi Qiu, Shijia Lin, Xiaolu Zhou, Jiachao Zhang, Shuaiming Jiang   +8 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Pharmacokinetics and Safety of Fenofibrate in Participants with Mild Hepatic Impairment or with Advanced Fibrosis due to Metabolic‐Associated Fatty Liver Disease

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fenofibrate is contraindicated in patients with advanced hepatic fibrosis due to limited clinical data. We evaluated the pharmacokinetics and safety of fenofibrate in participants with mild hepatic impairment (phase 1 study) or advanced fibrosis due to metabolic‐associated fatty liver disease (MAFLD; phase 2a study).
Islam R. Younis, Elijah J. Weber, Cara Nelson, Ann R. Qin, Timothy R. Watkins, Ahmed A. Othman   +5 more
wiley   +1 more source

Enhanced serum-based seed amplification assay for detecting propagative α-synuclein seeds in Parkinson's disease. [PDF]

Transl Neurodegener
Kuang Y, Mao H, Dai W, Gan T, Lin H, Li J, Yang X, Xu P.   +7 more
europepmc   +1 more source

Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Posttraumatic osteoarthritis (PTOA) is a common sequela to anterior cruciate ligament (ACL) injury in humans and dogs. Identification of conserved targets between species may hasten biomarker identification and therapeutic development. To identify differentially regulated synovial fluid (SF) proteins in ACL injury, SF samples were collected ...
Sydney J. Womack, Camila B. Carballo, Erica J. Secor, Scott A. Rodeo, Heidi L. Reesink   +4 more
wiley   +1 more source

Apolipoproteins in Psoriasis: The Effect of Acitretin Treatment and UVB Phototherapy. [PDF]

Metabolites
Myśliwiec H, Kozłowska D, Hodun K, Łukaszuk B, Owczarczyk-Saczonek A, Chabowski A, Flisiak I.   +6 more
europepmc   +1 more source

Apolipoprotein A-V [PDF]

, 2018
D. Peetz, K. J. Lackner
openaire   +3 more sources

GCKR Polymorphisms Increase the Risks of Low Bone Mineral Density in Young and Non‐Obese Patients With MASLD and Hyperuricemia

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic‐associated steatotic liver disease (MASLD) encompasses common comorbidities including low bone mineral density (BMD) and hyperuricemia (HU), yet relevant genetic analyses are limited. This study aimed to investigate the genetic effects of risk single nucleotide polymorphisms (SNPs) on the occurrence of low BMD in patients with MASLD ...
Tzu‐Hao Li, Yu‐Shin Huang, Chia‐Chen Ma, Shin‐Yu Tsai, Hung‐Cheng Tsai, Hsiao‐Yun Yeh, Hsiao‐Chin Shen, Shiao‐Ya Hong, Chien‐Wei Su, Hwai‐I Yang, Ying‐Ying Yang, Ming‐Chih Hou   +11 more
wiley   +1 more source

Apolipoprotein and menopausal status are significant influencing factors for diabetic retinopathy in type II diabetes mellitus women. [PDF]

Sci Rep
Pei X, Yao X, Qi D, Yang Y, Fan S, Li Z.
europepmc   +1 more source