Results 151 to 160 of about 40,273 (244)

Correction: Novel Insights into Causal Effects of Serum Lipids and Apolipoproteins on Cardiovascular Morpho-Functional Phenotypes. [PDF]

Cardiovasc Toxicol
Liu A, Liu X, Wei Y, Xiang X, Chen Y, Zheng Z, Xu C, Yang S, Zhao K.   +8 more
europepmc   +1 more source

Apolipoprotein E [PDF]

, 2011
openaire   +1 more source

Population Pharmacokinetics and Exposure‐Response Modeling for Evinacumab in Children, Adolescents, and Adults With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 (ANGPTL3) inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C), independent of low‐density lipoprotein receptor, in patients with homozygous familial hypercholesterolemia (HoFH). A population pharmacokinetic (PK)/pharmacodynamic (PD) model was previously developed to characterize ...
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Yuhuan Wang, Poulabi Banerjee, Robert Pordy, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +8 more
wiley   +1 more source

Comparison of Model‐Predicted and Observed Evinacumab Pharmacokinetics and Efficacy in Children Aged < 5 Years With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in < 5‐year‐old patients with HoFH.
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Katy C. Norman, Richard T. George, Xue‐Qiao Zhao, Robert Pordy, Daniel Garcia, Wendy S. Putnam, Geetha Raghuveer, Brian W. McCrindle, Elena Fornari, Ivo Baric, Shubha Srinivasan, Melissa Diamond, Eliot A. Brinton, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +18 more
wiley   +1 more source

The Impact of Cannabidiol (CBD) on Lipid Absorption and Lymphatic Transport in Rats. [PDF]

Nutrients
Zhu Q, Yang Q, Shen L, Xu M, Liu M.
europepmc   +1 more source

Use of Model‐Based Meta‐Analysis to Inform the Design of Early Clinical Trials of Anti‐Amyloid Beta Therapies in Alzheimer's Disease

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT To inform an efficient development of new investigational anti‐amyloid beta (anti‐Aβ) monoclonal antibodies (mAbs), a modeling‐and‐simulation‐based strategy was proposed. A general modeling framework that links drug exposures to the time course of amyloid plaque removal and amyloid‐related imaging abnormalities characterized by edema and ...
Sagar S. Bachhav, Ana Victoria Ponce‐Bobadilla, Diana Clausznitzer, Sven Stodtmann, Hao Xiong   +4 more
wiley   +1 more source

Novel Insights into Causal Effects of Serum Lipids and Apolipoproteins on Cardiovascular Morpho-Functional Phenotypes. [PDF]

Cardiovasc Toxicol
Liu A, Liu X, Wei Y, Xiang X, Chen Y, Zheng Z, Xu C, Yang S, Zhao K.   +8 more
europepmc   +1 more source

Fusogenic Nanoreactor‐Based Detection of Extracellular Vesicle‐derived miRNAs for Diagnosing Atherosclerosis

Small, EarlyView.
This study introduces an all‐in‐one diagnostic system that amplifies target genes through interactions between serum EVs and fusogenic liposomes. Using padlock probes and enzymes within liposomes, the system enables miRNA amplification upon fusion. It successfully detects miR‐33a, miR‐126, and miR‐145, showing strong diagnostic performance comparable ...
Jiyoon Lee, Kiyoon Kwon, Min Ji Cho, Taesang Son, Yuna Roh, Sugi Lee, Dae‐Soo Kim, Moo‐Seung Lee, Hyun Seung Ban, Jang‐Seong Kim, Eun‐Kyung Lim, Sang‐Hak Lee, Goo Taeg Oh, Jong‐Gil Park, Tae‐Su Han   +14 more
wiley   +1 more source

Low apolipoprotein A-II levels causally contribute to increased mortality in septic shock. [PDF]

J Intensive Care
Takahashi N, Campbell KR, Shimada T, Nakada TA, Russell JA, Walley KR.   +5 more
europepmc   +1 more source

Exploring 2D Graphene‐Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective

Small Science, EarlyView.
Two‐dimensional graphene‐based nanomaterials are of significant interest in biomedical applications due to their unique physicochemical properties. Computational modeling provides useful insights into their structure and interactions with biological systems, aiding the nanoparticle design.
Alexa Kamboukos, Nevena Todorova, Irene Yarovsky   +2 more
wiley   +1 more source