ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi +6 more
wiley +1 more source
High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice [PDF]
, 2010 Peter Kanellakis +10 more
openalex +1 more source
Exploring the role of apolipoprotein ε4 in progressive myoclonic epilepsy type 1
Epileptic Disorders, EarlyView.Abstract Objective Progressive myoclonic epilepsy type 1 (EPM1) is a neurodegenerative disease caused by biallelic variants in the cystatin B (CSTB) gene. Despite a progressive course, phenotype severity varies among patients, even within families. We studied the potential role of APOE ε4 in modifying phenotypic diversity in EPM1, given its established
Janina Gunnar +10 more
wiley +1 more source
Protein deglycosylation can drastically affect the cellular uptake [PDF]
, 2019 Ghazaryan, A. +2 more
core +2 more sources
Equine Veterinary Journal, EarlyView.Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka +4 more
wiley +1 more source
Lipids, lipoproteins, and apolipoproteins: Associations with cognition and dementia [PDF]
Ida Juul Rasmussen +2 more
openalex +1 more source
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis [PDF]
, 2011 Micha M.M. Wilhelmus +6 more
openalex +1 more source
Peach Kernel Oil Modulates Lipid Metabolism Disorder in ApoEa CRISPR/Cas9 Gene‐Disrupted Zebrafish
Food Frontiers, EarlyView.In this study, we used CRISPR/Cas9 gene editing technology to establish a lipid metabolism disorder model of ApoEa mutant zebrafish. We applied peach kernel oil to this model and studied the mechanism of peach kernel oil regulating lipid disorder in combination with transcriptomics.
Lei Xia +14 more
wiley +1 more source
The functions of apolipoproteins and lipoproteins in health and disease
Molecular BiomedicineLipoproteins and apolipoproteins are crucial in lipid metabolism, functioning as essential mediators in the transport of cholesterol and triglycerides and being closely related to the pathogenesis of multiple systems, including cardiovascular ...
Zijun Ma +4 more
doaj +1 more source
Apolipoprotein A and B (Sf 100-400) metabolism during bezafibrate therapy in hypertriglyceridemic subjects. [PDF]
, 1984 J. Shepherd +9 more
openalex +1 more source