Results 201 to 210 of about 40,273 (244)

The Lipidomic Profile Discriminates Between MASLD and MetALD

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 8, Page 1357-1371, April 2025.
HDL‐centric lipidomic biomarkers, particularly within large and medium HDL subfractions, distinguish metabolic dysfunction and alcohol‐related liver disease from metabolic dysfunction‐associated steatotic liver disease, suggesting potential biomarkers for clinical differentiation.
Kai Markus Schneider, Feng Cao, Helen Ye Rim Huang, Lanlan Chen, Yazhou Chen, Rongpeng Gong, Anastasia Raptis, Kate Townsend Creasy, Jan Clusmann, Felix van Haag, Paul‐Henry Koop, Adrien Guillot, Tom Luedde, Rohit Loomba, Sven Francque, Carolin Victoria Schneider   +15 more
wiley   +1 more source

Lipoprotein receptors: A little grease for enveloped viruses to open the lock? [PDF]

J Biol Chem
Cosset FL, Denolly S.
europepmc   +1 more source

Clearance of Hepatitis C Viremia During Direct‐Acting Antiviral Therapy Leads to Rapid Changes in Lipid and Lipoprotein Metabolism

Alimentary Pharmacology &Therapeutics, EarlyView.
HCV clearance during direct‐acting antiviral therapy rapidly increases serum lipids and lipoproteins, potentially elevating cardiovascular risk. These metabolic changes, mediated by genes regulating hepatic lipogenesis, suggest that lipid levels should be closely monitored post‐SVR to assess long‐term cardiovascular implications.
Zahra Sarrafan‐Chaharsoughi, Varun Takyar, Sungyoung Auh, Gavin Nee, Ahmad Alawad, Brent S. Abel, Devika Kapuria, Colleen Byrnes, Anna Wolska, David E. Kleiner, Robert Shamburek, Alan T. Remaley, Marc G. Ghany   +12 more
wiley   +1 more source

Activating transcription factor 3 regulates hepatic apolipoprotein A4 upon metabolic stress. [PDF]

J Biol Chem
Encarnacion J, Smith DM, Choi J, Scafidi J, Wolfgang MJ.   +4 more
europepmc   +1 more source

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, EarlyView.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

Apolipoproteins, lipids, lipid-lowering drugs and risk of amyotrophic lateral sclerosis and frontotemporal dementia: a meta-analysis and Mendelian randomisation study. [PDF]

J Neurol
Chalitsios CV, Ley H, Gao J, Turner MR, Thompson AG.   +4 more
europepmc   +1 more source

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, EarlyView.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Truncated variant rs373056577 confers increased risk of type 2 diabetes and missense variant rs121912717 is associated with hypertriglyceridemia in Bangladeshi population. [PDF]

Metabol Open
Sayed S, Saba AA, Hasan I, Rahat R, Sayem M, Ebihara A, Nabi AHMN.   +6 more
europepmc   +1 more source