Results 71 to 80 of about 40,273 (244)

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease [PDF]

, 2017
Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system.
Matsakas, Antonios, Sfyri, Peggy
core   +1 more source

Apolipoproteins and Alzheimer's pathophysiology

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
AbstractIntroductionApolipoproteins of demonstrated importance to brain cholesterol and ß‐amyloid metabolism may serve as novel risk markers for Alzheimer's pathology.MethodsWe measured apolipoproteins (apoE, apoJ, apoA‐I, and apoC‐III and their uniquely defined subspecies) by enzyme‐linked immunosorbent assay in plasma collected in 2000 and 2008 from ...
Oscar L. Lopez, Annette L. Fitzpatrick, Kenneth J. Mukamal, Jeremy D. Furtado, Steven T. DeKosky, Majken K. Jensen, Manja Koch, Timothy M. Hughes, Rachel H. Mackey, Lewis H. Kuller   +9 more
openaire   +4 more sources

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Advanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo, Youngjun Kim, Rian Kang, Seho Lee, Dang Du Nguyen, Soomin Park, Dongjoon Lee, Jong Won Han, Inhee Mook‐Jung, Luke P. Lee, Jong‐Chan Park, Inki Kim   +11 more
wiley   +1 more source

Serum apolipoprotein profile of patients with chronic renal failure [PDF]

, 1987
Serum apolipoprotein profile of patients with chronic renal failure. Serum concentrations of apolipoproteins A-I, A-II, B, C-I, C-II, C-III and E were determined by electroimmunoassay in 56 patients with chronic renal failure (CRF) in the predialytic ...
Alaupovic, Petar, Attman, Per-Ola, Gustafson, Anders   +2 more
core   +1 more source

Metabolism of apolipoprotein A-IV

Journal of Lipid Research, 1984
The terms “lipoprotein-free’’ and “lipoproteinassociated” are used to denote those studies in which apoA-IV was fractionated by means other than ultracentrifugation. Because of the introduction of artifacts by ultracentrifugation and a reliance of different physical properties for separation by the alternative methods, “lipoprotein- free” and ...
Michael Lefevre, Paul S. Roheim
openaire   +4 more sources

UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification

Advanced Science, EarlyView.
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia, He Zhang, Dingqiang Mo, Bo Xie, Hongdou Qiao, Tao Chen, Haoyue Song, Xinxin Xu, Sheng Yang   +8 more
wiley   +1 more source

Lipoprotein particles in patients with pediatric Cushing disease and possible cardiovascular risks. [PDF]

, 2019
BackgroundCardiovascular (CV) complications are the most significant cause of mortality in adults with Cushing disease (CD); little is known about CV risk factors in children with CD.
Belyavskaya, Elena, Cheung, Anita, De La Luz Sierra, Maria, Keil, Meg, Lodish, Maya, Lyssikatos, Charalampos, Makri, Angeliki, Remaley, Alan T, Sampson, Maureen, Sinaii, Ninet, Stratakis, Constantine A   +10 more
core  

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source