Results 31 to 40 of about 12,961,080 (334)

Chromosomal breaks at the origin of small tandem DNA duplications

BioEssays, Volume 45, Issue 1, January 2023., 2023
Small tandem DNA duplications form a specific mutational signature frequently found in human disease alleles and cancer genes. Here we hypothesize that these duplications mainly arise at chromosomal DNA breaks that result from two closely located single‐stranded nicks, through error‐prone repair by the non‐homologous end‐joining pathway. Abstract Small
Joost Schimmel, Marloes D. van Wezel, Robin van Schendel, Marcel Tijsterman   +3 more
wiley   +1 more source

Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans.

Proceedings of the National Academy of Sciences of the United States of America, 1993
The concentration of triglyceride-rich lipoproteins containing apolipoprotein (apo) B-48 (chylomicrons) and apo B-100 (very low density lipoproteins) was measured in blood plasma of healthy young men after an ordinary meal containing one-third of daily ...
B. Schneeman, L. Kotite, K. Todd, R. Havel   +3 more
semanticscholar   +1 more source

Evidence of emerging BBB changes in mid‐age apolipoprotein E epsilon‐4 carriers

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
This study demonstrated a tendency towards BBB permeability in APOEε4 participants emerging from mid‐age, with quantitative differences observable on a number of the measures. Results from this study may help identify at‐risk populations at an early stage which will be crucial in facilitating the development of early interventions to change the ...
Nourah M. Alruwais, Jenifer M. Rusted, Naji Tabet, Nicholas G. Dowell   +3 more
wiley   +1 more source

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022
Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin, Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Chengcheng Wang, Qiang Xu   +6 more
wiley   +1 more source

Influence of liver cancer on lipid and lipoprotein metabolism

Lipids in Health and Disease, 2006
Liver plays a key role in the metabolism of plasma apolipoproteins, endogenous lipids and lipoproteins. Hepatocellular carcinoma (HCC) is one of the most common fatal malignant tumors in China and in other Southeast Asian countries.
Nilsson-Ehle Peter, Jiang Jingting, Xu Ning   +2 more
doaj   +1 more source

The Association of Hepatitis C Virus Glycoproteins with Apolipoproteins E and B Early in Assembly Is Conserved in Lipoviral Particles*

Journal of Biological Chemistry, 2014
Background: The mechanisms initiating the association between HCV and lipoprotein components to give lipoviral-particles remains elusive. Results: HCV E1E2 interacts with apolipoproteins B and E to produce a protein complex, which is found in mature ...
Audrey Boyer, Amélie Dumans, É. Beaumont, Loïc Etienne, P. Roingeard, J. Meunier   +5 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

APOLIPOPROTEIN A1 AND B ENHANCE INTERNALIZATION AND INFECTION OF DENGUE VIRUS SEROTYPE 2 (DENV2) IN HUH-7 CELL LINES

International Journal of Infectious Diseases, 2023
Intro: Previous studies have suggested an association between HDL, LDL cholesterol and dengue severity; however, the molecules involved in dengue virus (DENV) entry remain poorly understood. This study aims to determine the effects of apolipoproteins A1,
R. Ahmad, F. Mohd Nor, W. Seok Mui, T.H. Abdul Rahman   +3 more
doaj  

Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production [PDF]

Journal of Lipid Research, 2000
In vitro studies have shown that the binding site for microsomal triglyceride transfer protein (MTP) is within the first 17% of apoB (apoB-17). Expression of apoB-48 in McArdle cells decreases endogenous lipoprotein production; however, overexpression of human apoB in transgenic mice does not decrease endogenous mouse apoB expression.
Zhaohui Li, Jane M. Glick, Mason W. Freeman, Xinzhong Wang, Ling Pang, Yuko Kako, Ira J. Goldberg   +6 more
openaire   +4 more sources