Effect of APOE ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in circulating extracellular vesicles from cognitively impaired with no dementia participants converted to Alzheimer's disease [PDF]
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021 Introduction The substantial link between apolipoprotein E (APOE) ε4 allele and oxidative stress may underlie enhanced Alzheimer's disease (AD) risk. Here, we studied the impact of APOE ε4 on the level of apolipoproteins with antioxidant activities along
Mohamed Raâfet Ben Khedher +3 more
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Aqueous Humor Apolipoprotein Concentration and Severity of Diabetic Retinopathy in Type 2 Diabetes [PDF]
Mediators of Inflammation, 2022 An imbalance of plasma apolipoproteins has been linked to diabetic retinopathy (DR); however, there is scarce information regarding their presence in the aqueous humor (AH) and their role in DR.
Lucia Saucedo +4 more
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HDL‐Apolipoprotein in Alzheimer's Disease Revisited: From Periphery to CNS [PDF]
Aging MedicineHigh‐density lipoprotein (HDL), as a crucial component of lipid metabolism, have roles in regulating Alzheimer's disease (AD) core pathology amyloid β (Aβ) and phosphorylated tau (p‐tau) through its apolipoproteins, which are associated with brain ...
Yihong Huang +8 more
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The Association between Apolipoprotein E Genotypes and Serum Malondialdehyde Level with End-Stage Renal Disease [PDF]
Iranian Journal of Medical Sciences, 2023 Background: The Apolipoprotein E (ApoE) polymorphism plays an important role in the pathophysiology of end-stage renal disease (ESRD). Additionally, ApoE may contribute to the progression of oxidative stress.
Daryoush Pourmand +3 more
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The Effects of PPAR Agonists on Atherosclerosis and Nonalcoholic Fatty Liver Disease in ApoE−/−FXR−/− Mice [PDF]
Endocrinology and Metabolism, 2021 Background Farnesoid X receptor (FXR), a bile acid–activated nuclear receptor, is a potent regulator of glucose and lipid metabolism as well as of bile acid metabolism.
Yenna Lee +7 more
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Alzheimer's disease related heart structural and functional damage
Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Alzheimer's disease (AD) is a common neurological degenerative disease that can cause structural and functional abnormalities of the heart. Amyloid⁃β protein (Aβ) and AD⁃related gene variants play important roles in the pathophysiological changes of the ...
Shu⁃yu LIU, Wei ZHANG
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Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses. [PDF]
PLoS ONE, 2015 Apolipoprotein E (ApoE), an exchangeable apolipoprotein, is necessary for production of infectious Hepatitis C virus (HCV) particles. However, ApoE is not the only liver-expressed apolipoprotein and the role of other apolipoproteins for production of ...
Kathrin Hueging +11 more
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Arquivos de Neuro-Psiquiatria, 2022 Background Some studies show an association between the apolipoprotein E ε4 allele (ApoEε4) and obstructive sleep apnea syndrome (OSAS), and other studies, an association between ApoEε4 and excessive daytime sleepiness (EDS), but there are no data in the
Fernanda Maurer Balthazar +4 more
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Apolipoprotein E and Alzheimer's Disease [PDF]
Annual Review of Neuroscience, 1995 The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease. The APOE4 allele increases the probability of disease at an earlier age. In contrasL the APOE3 and APOE2 alleles decrease the probability of disease and increase the age of onset. Therefore the metabolism of apolipoprotein E is relevant
Allen D. Roses, Warren J. Strittmatter
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Apolipoprotein E and Alzheimer's disease
Acta Pharmaceutica Sinica B, 2022 Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk. APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk is dose dependent, as those carrying one APOE ε4 allele have a 2-3-fold increased risk, while those carrying two ε4 alleles have a 10-15-fold increased risk.
Benjamin R. Troutwine +4 more
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