Results 1 to 10 of about 18,538,974 (359)

Effect of APOE ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in circulating extracellular vesicles from cognitively impaired with no dementia participants converted to Alzheimer's disease [PDF]

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction The substantial link between apolipoprotein E (APOE) ε4 allele and oxidative stress may underlie enhanced Alzheimer's disease (AD) risk. Here, we studied the impact of APOE ε4 on the level of apolipoproteins with antioxidant activities along
Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin, Charles Ramassamy   +3 more
doaj   +2 more sources

Exploring the evolving role of apolipoproteins in oncology: global trends and emerging frontiers [PDF]

Journal of Cancer Research and Clinical Oncology
Background Metabolic reprogramming, especially lipid metabolism, is crucial in cancer progression and treatment resistance. Apolipoproteins are crucial targets for research as they regulate autophagy, oxidative stress, and chemoresistance.
Dianzhe Tian, Zixuan Hu, Zuyi Yang, Lvyuxing Zhao, Haitao Zhao, Xinting Sang, Shunda Du, Yunping Luo, Lei Zhang, Yiyao Xu, Xin Lu   +10 more
doaj   +2 more sources

HDL‐Apolipoprotein in Alzheimer's Disease Revisited: From Periphery to CNS [PDF]

Aging Medicine
High‐density lipoprotein (HDL), as a crucial component of lipid metabolism, have roles in regulating Alzheimer's disease (AD) core pathology amyloid β (Aβ) and phosphorylated tau (p‐tau) through its apolipoproteins, which are associated with brain ...
Yihong Huang, Jingyi Tang, Guohua Chen, Qiangqiang Wu, Yongfei Wang, Jianjun Chen, Simei Chen, Jun Liu, Xiaoyun Huang   +8 more
doaj   +2 more sources

The Effects of PPAR Agonists on Atherosclerosis and Nonalcoholic Fatty Liver Disease in ApoE−/−FXR−/− Mice [PDF]

Endocrinology and Metabolism, 2021
Background Farnesoid X receptor (FXR), a bile acid–activated nuclear receptor, is a potent regulator of glucose and lipid metabolism as well as of bile acid metabolism.
Yenna Lee, Bo-Rahm Kim, Geun-Hyung Kang, Gwan Jae Lee, Young Joo Park, Haeryoung Kim, Hak Chul Jang, Sung Hee Choi   +7 more
doaj   +1 more source

Alzheimer's disease related heart structural and functional damage

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Alzheimer's disease (AD) is a common neurological degenerative disease that can cause structural and functional abnormalities of the heart. Amyloid⁃β protein (Aβ) and AD⁃related gene variants play important roles in the pathophysiological changes of the ...
Shu⁃yu LIU, Wei ZHANG
doaj   +1 more source

The Association between Apolipoprotein E Genotypes and Serum Malondialdehyde Level with End-Stage Renal Disease [PDF]

Iranian Journal of Medical Sciences, 2023
Background: The Apolipoprotein E (ApoE) polymorphism plays an important role in the pathophysiology of end-stage renal disease (ESRD). Additionally, ApoE may contribute to the progression of oxidative stress.
Daryoush Pourmand, Asad Veisi-Raygani, Fariborz Bahrehmand, Soheila Asadi   +3 more
doaj   +1 more source

Interaction between apolipoprotein E genotypes, excessive daytime sleepiness, and cognitive function in obstructive sleep apnea patients

Arquivos de Neuro-Psiquiatria, 2022
Background Some studies show an association between the apolipoprotein E ε4 allele (ApoEε4) and obstructive sleep apnea syndrome (OSAS), and other studies, an association between ApoEε4 and excessive daytime sleepiness (EDS), but there are no data in the
Fernanda Maurer Balthazar, Walter André dos Santos Moraes, James Richard Hunter, Gilmar Fernandes do Prado, Luciane Bizari Coin de Carvalho   +4 more
doaj   +1 more source

Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses. [PDF]

PLoS ONE, 2015
Apolipoprotein E (ApoE), an exchangeable apolipoprotein, is necessary for production of infectious Hepatitis C virus (HCV) particles. However, ApoE is not the only liver-expressed apolipoprotein and the role of other apolipoproteins for production of ...
Kathrin Hueging, Romy Weller, Mandy Doepke, Gabrielle Vieyres, Daniel Todt, Benno Wölk, Florian W R Vondran, Robert Geffers, Chris Lauber, Lars Kaderali, François Penin, Thomas Pietschmann   +11 more
doaj   +1 more source

Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver.

Journal of Lipid Research, 1985
Like rat C apolipoproteins, each of the C apolipoproteins from human blood plasma (C-I, C-II, C-III-1, and C-III-2) bound to small chylomicrons from mesenteric lymph of estradiol-treated rats and inhibited their uptake by the isolated perfused rat liver.
E Windler, R J Havel
doaj   +1 more source

Aqueous Humor Apolipoprotein Concentration and Severity of Diabetic Retinopathy in Type 2 Diabetes

Mediators of Inflammation, 2022
An imbalance of plasma apolipoproteins has been linked to diabetic retinopathy (DR); however, there is scarce information regarding their presence in the aqueous humor (AH) and their role in DR.
Lucia Saucedo, Isabel B. Pfister, Christin Schild, Souska Zandi, Justus G. Garweg   +4 more
doaj   +1 more source