Results 171 to 180 of about 21,816 (261)

The association between two common levels of apolipoprotein and chronic obstructive pulmonary disease: A Mendelian randomized study. [PDF]

Medicine (Baltimore)
Chen C, Sun Z, Zhong W, Zheng H, Zuo Z, Zhang X, Wang Y, Zhao W, Shen B.   +8 more
europepmc   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

People living with HIV on modern antiretrovirals do not display a pro-atherogenic lipid profile and have similar body composition compared to healthy controls. [PDF]

HIV Med
Savinelli S, Heeney A, Tinago W, Garcia Leon AA, McGettrick P, Cotter AG, Walsh I, Fitzgibbon M, Sabin CA, Mallon PWG, Feeney ER, HIV UPBEAT study group.   +11 more
europepmc   +1 more source

Human breast milk lipoproteins: A preliminary biochemical characterization

Experimental Physiology, EarlyView.
Abstract Human breast milk (BM) is an essential fluid for infant development, with a dynamic composition adapted to the infant's needs. It contains bioactive lipids like cholesterol, typically transported by lactosomes, extracellular vesicles, and milk fat globules. However, classic cholesterol‐carrying lipoproteins have not been described in BM.
Gabriela Arenas, Andrea Morales, Andrea Leiva, Susana Contreras‐Duarte   +3 more
wiley   +1 more source

Sex Differences in Lipids and Lipoproteins and Their Relationship With Cardiovascular Disease: A Prospective Study of UK Biobank Participants. [PDF]

J Am Heart Assoc
Kelly RK, Harris K, Muntner P, Woodward M.   +3 more
europepmc   +1 more source

A high‐fat, high‐sucrose diet exacerbates muscle and metabolic pathology and undermines glucocorticoid efficacy in dystrophin‐deficient mice

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat, high‐sucrose diet (HFHSD) exacerbated muscle and metabolic dysregulation in mdx mice while also altering the physiological response to prednisolone (Pred) In diaphragms of control diet (CD)‐fed mdx mice, prednisolone treatment improved muscle function and reduced fibrosis, inflammatory signalling, and mitochondrial ...
Morgan E. Vorwald, Swathy Krishna, Ji Heun Lee, Melissa Roths, Rudy J. Valentine, Joshua T. Selsby   +5 more
wiley   +1 more source

Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. [PDF]

Arterioscler Thromb Vasc Biol
Reijnders E, Bossuyt PM, Jukema JW, Ruhaak LR, Romijn FPHTM, Szarek M, Trompet S, Bhatt DL, Bittner VA, Diaz R, Fazio S, Stevanovic I, Goodman SG, Harrington RA, White HD, Steg PG, Schwartz GG, Cobbaert CM.   +17 more
europepmc   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

A rapid and reliable strategy for identification of LNP and protein corona in vitro and in vivo. [PDF]

Int J Pharm X
Wang R, Wang H, Li T, Zi G, Yang Z, Xu Y, Peng B.   +6 more
europepmc   +1 more source

APOE4 negates the effects of ovarian hormones on cerebrovascular endothelial and mitochondrial function

The Journal of Physiology, EarlyView.
Abstract figure legend We examined the interaction effect of ovarian hormones and APOE genotype on cerebrovascular and mitochondrial function. Our data revealed that APOEε3 mice that were ovariectomized exhibited impaired endothelial function and greater oxidative stress and inflammation compared to sham controls.
Mackenzie N. Kehmeier, Alexandra Famiano, Abigail E. Cullen, Thomas Leonhardt, Skylyn J. Ferguson, Madeleine Snyder, Carrie E. McCurdy, Daniel J. Tyrrell, Nabil J. Alkayed, Ashley E. Walker   +9 more
wiley   +1 more source