Results 161 to 170 of about 21,852 (261)

Spatial Characterization of the Human Meniscus: Bridging Biomechanics and Biochemistry Using Atomic Force Microscopy Micro‐Indentation and Mass Spectrometry Imaging

Small Methods, EarlyView.
A multimodal imaging approach combines AFM micro‐indentation and MALDI mass spectrometry imaging on the same fresh‐frozen human meniscus section to directly associate microscale mechanics with molecular composition. Collagen‐rich regions exhibit increased stiffness, whereas zones enriched in other extracellular matrix proteins are mechanically less ...
Aleksandra N. Lebedeva, Martin Handelshauser, Orestis G. Andriotis, Lena Hirtler, Martina Marchetti‐Deschmann, Philipp J. Thurner   +5 more
wiley   +1 more source

A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E. [PDF]

Adv Sci (Weinh)
Sebastiani P, Reed E, Chandler KB, Lopez P, Lords H, Bae H, Costello CE, Au M, Deng LL, Li M, Xiang Q, Noh H, Pflieger L, Funk C, Rappaport N, Nygaard M, Short MI, Brent M, Monti S, Andersen SL, Perls TT.   +20 more
europepmc   +1 more source

Hormone Replacement Therapy for Menopausal Symptoms and the Risk of Cardiometabolic Disease: Current Evidence and Future Directions

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background The transition through menopause is accompanied by a series of adverse metabolic changes which are associated with an increased risk of cardiometabolic disease, a major cause of mortality in women after midlife. Whilst the indication for menopausal hormone replacement therapy (HRT) is the control of menopausal symptoms ...
Jiawen Dong, Sarah Hillman, Sharon Dixon, Anupa Shah, Radha Venkatakrishnan, Jeremy W. Tomlinson   +5 more
wiley   +1 more source

Alterations of Apolipoprotein A1, E, and J Genes in the Frontal Cortex in an Ischemic Model of Alzheimer's Disease with 2-Year Survival. [PDF]

Int J Mol Sci
Pluta R, Ułamek-Kozioł M, Kocki J, Bogucka-Kocka A, Bogucki J, Czuczwar SJ.   +5 more
europepmc   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

Characterizing lipoprotein profiles in coronary atherosclerosis development through quantitative lipidomics and proteomics approaches. [PDF]

NPJ Cardiovasc Health
Takeda H, Izumi Y, Koike Y, Koike T, Nakatani K, Hata K, Matsumoto M, Shiomi M, Bamba T.   +8 more
europepmc   +1 more source

Genome‐wide association and interaction analysis for proliferative retinopathy in adults with type 2 diabetes born during famine: The DOLCE study in Ukraine

Acta Ophthalmologica, EarlyView.
Abstract Purpose Proliferative diabetic retinopathy (PDR) is one of the leading causes of blindness in working‐age adults. We have previously shown that the risk of PDR is significantly elevated in individuals with intrauterine exposure to famine. However, the genetic mechanisms mediating this association remain unknown.
Olena Fedotkina, Most Champa Begum, Xuan Tung Trinh, Turkuler Özgumus, Mikael Åkerlund, Peter Nilsson, Leticia Maria Spindola, Valeriya Lyssenko   +7 more
wiley   +1 more source

SAA4: An Underdog Within the Serum Amyloid a Superfamily? [PDF]

Int J Mol Sci
Malle E, Madreiter-Sokolowski C, Windpassinger C.   +2 more
europepmc   +1 more source

Screen‐Detected Coeliac Disease in a Nationally Representative Cohort: Health Indicators, Long‐Term Outcomes and Mortality

Alimentary Pharmacology &Therapeutics, EarlyView.
In a nationally representative Finnish cohort, screen‐detected coeliac disease was associated with iron deficiency, anaemia, and an atherogenic lipid profile at diagnosis, but long‐term gluten‐free treatment did not adversely affect quality of life, metabolic health, or mortality; supporting a favourable benefit‐harm balance for population‐based ...
Iida Ahonen, Kalle Kurppa, Heini Huhtala, Katri Kaukinen, Laura Kivelä, Juha Taavela   +5 more
wiley   +1 more source

Plasma proteomic profiles of patients during oral anti-coagulant treatment with vitamin K antagonists. [PDF]

Br J Haematol
Camilleri E, van Vlijmen BJM, Bos MHA, Wuhrer M, Goodlett DR, Borchers CH, Cannegieter SC, van Rein N, Mohammed Y.   +8 more
europepmc   +1 more source