Results 181 to 190 of about 21,816 (261)

National Trends and Disparities in Cancer Mortality Among Individuals With Alzheimer's Disease and Related Dementias in the United States, 1999–2020

open access: yesComputational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT As population aging accelerates, the coexistence of cancer and Alzheimer's disease and related dementias (ADRD) is becoming increasingly common. While each condition independently contributes to mortality, national trends in cancer‐related deaths occurring alongside ADRD—and their demographic and geographic disparities—remain poorly defined ...
Aasim Ali   +14 more
wiley   +1 more source

Applying Bayesian Multivariable Mendelian Randomisation to Prioritise Candidate Causal Traits From High‐Dimensional Data: Illustration From Estimation of the Effect of Maternal Metabolites on Offspring Birthweight

open access: yesGenetic Epidemiology, Volume 50, Issue 6, September 2026.
ABSTRACT Mendelian randomisation (MR) is an approach to causal inference that uses genetic variants to infer whether or not a causal effect exists, unbiased by unobserved confounding. MR estimation usually considers the effect of a single exposure on an outcome; it has recently been extended to explore potential effects of multiple exposures using ...
Ciarrah‐Jane Barry   +5 more
wiley   +1 more source

High‐density mutation tracks are associated with proton‐beam irradiation patterns in Sorghum bicolor

open access: yesThe Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Induced mutagenesis is a cornerstone of crop functional genomics, yet the extent to which distinct radiation sources reshape the spatial distribution of mutations remains difficult to evaluate in reduced‐representation datasets. Here, we analyze a published genotyping‐by‐sequencing (GBS) panel (192,040 loci) to compare proton‐beam and gamma ...
Ezekiel Ahn   +6 more
wiley   +1 more source

Single‐Nucleus Multiomic Analysis Reveals Immune–Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV‐Associated Neurocognitive Disorders

open access: yesGlia, Volume 74, Issue 8, August 2026.
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez   +8 more
wiley   +1 more source

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