Results 71 to 80 of about 64,094 (275)

Attenuation of oxidative stress, inflammation and apoptosis by ethanolic and aqueous extracts of Crocus sativus L. stigma after chronic constriction injury of rats

Anais da Academia Brasileira de Ciências, 2014
In our previous study, the ethanolic and aqueous extracts of Crocus sativus elicited antinociceptive effects in the chronic constriction injury (CCI) model of neuropathic pain. In this study, we explored anti-inflammatory, anti-oxidant and anti-apoptotic
BAHAREH AMIN, KHALIL ABNOUS, VAHIDEH MOTAMEDSHARIATY, HOSSEIN HOSSEINZADEH   +3 more
doaj   +1 more source

Effects of Panax ginseng, Turnera diffusa and Heteropterys tomentosa extracts on hippocampal apoptosis of aged rats

Einstein (São Paulo)
OBJECTIVE: To verify if the medicinal plants Panax ginseng C.A. Mey, Turnera diffusa Willd. ex Schult., and Heteropterys tomentosa O. Mach., which are amply used by the population as tonics and cognition enhancers, could have a protective effect on cell ...
Andréia Gomes Bezerra, Soraya Soubhi Smaili, Guiomar Silva Lopes, Elisaldo Araújo Carlini   +3 more
doaj   +1 more source

Apoptose em pólipos nasais eosinofílicos submetidos in vitro ao tratamento com mitomicina C Apoptosis in eosinophilic nasal polyps treated in vitro with mitomycin C

Brazilian Journal of Otorhinolaryngology, 2012
A etiopatogênese da polipose nasal eosinofílica ainda não foi esclarecida. Os eosinófilos constituem as principais células do infiltrado inflamatório e estão relacionados com a perpetuação do processo inflamatório na rinossinusite crônica com pólipos ...
Cláudia Pena Galvão dos Anjos, Anilton Cesar Vasconcelos, Paulo Fernando Tormin Borges Crosara, Gustavo Coelho dos Anjos, Celso Gonçalves Becker, Roberto Eustáquio Santos Guimarães   +5 more
doaj   +1 more source

Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies

Food Science &Nutrition, Volume 12, Issue 12, Page 10059-10069, December 2024.
Betulin and betulinic acid exhibit anticancer properties through mechanisms including the induction of autophagy, promotion of apoptosis, and anti‐inflammatory effects. These compounds enhance autophagy, facilitating cellular degradation and recycling processes, while selectively inducing apoptosis in cancer cells.
Elifsu Nemli, Beyza Saricaoglu, Celale Kirkin, Gulay Ozkan, Esra Capanoglu, Solomon Habtemariam, Javad Sharifi‐Rad, Daniela Calina   +7 more
wiley   +1 more source

Die Wirkungen von Peroxisomenproliferatoren auf primäre Hepatocyten aus der Regenbogenforelle (Oncorhynchus mykiss) und die permanente Fischzelllinie RTG-2 aus der Gonade der Regenbogenforelle [PDF]

, 2001
Clofibrat dient zur Senkung von Lipiden und Cholesterin im Blut. Es ist ein Peroxisomenproliferator in Ratten und Mäusen und kann Krebs auslösen. Diese Effekte werden in Primaten nicht beobachtet.
Berbner, Thomas
core   +1 more source

Ferroptose‐induzierender Co(III) Polypyridin Sulfasalazin Komplex für die verbesserte Krebstherapie

Angewandte Chemie, Volume 136, Issue 48, November 25, 2024.
Der gezielte Einsatz der Ferroptose ist ein neuer Weg, um die Grenzen der apoptotischen Krebsbekämpfung zu überwinden. Der hier beschriebene Co(III)‐Polypyridin‐Sulfasalazin‐Komplex wirkt als starker Ferroptose‐Induktor für die Krebstherapie. Dieser Komplex reichert sich selektiv in Mitochondrien an, wobei er reaktive Sauerstoffspezies erzeugt, die ...
Nicolás Montesdeoca, Lukas Johannknecht, Elizaveta Efanova, Jacqueline Heinen‐Weiler, Johannes Karges   +4 more
wiley   +1 more source

Entwicklung und funktionelle Charakterisierung rekombinanter Formen der pro-apoptotischen Enzyme Granzym B und Caspase-3 zur gezielten Induktion des programmierten Zelltods in Tumorzellen [PDF]

, 2004
Zytotoxische T-Lymphozyten und natürliche Killer-Zellen sind hochspezialisierte Zellen des Immunsystems, die durch Sekretion der Serin-Protease Granzym B (GrB) und des membranolytischen Proteins Perforin Virusinfizierte, körperfremde oder auch ...
Giesübel, Ulrike
core  

Die Click‐to‐Release‐Aktivierung des Reserveantibiotikums Colistin am Zielort verringert dessen Nierentoxizität

Angewandte Chemie, Volume 136, Issue 47, November 18, 2024.
Wir berichten, wie über eine Zwei‐Komponenten‐Strategie die starke Nierentoxizität des Antibiotikums Colistin verringert werden kann. Dazu werden nicht‐nephrotoxische trans‐Cycloocten‐Colistin‐Derivate durch das tetrazinverknüpfte, bakterienspezifische Peptid Ubiquicidin (29–41) über einen click‐to‐release‐Mechanismus aktiviert.
Jiraborrirak Charoenpattarapreeda, Werner Tegge, Chunfa Xu, Kirsten Harmrolfs, Bettina Hinkelmann, Hannah Wullenkord, Sven‐Kevin Hotop, Ulrike Beutling, Katharina Rox, Mark Brönstrup   +9 more
wiley   +1 more source

Apoptose e expressão de Bcl-2 e das caspases 3 e 8 em placenta bovina, em diferentes estádios de gestação Apoptosis and expression of Bcl-2 and caspases 3 and 8 in placenta of cows at different pregnancy stages

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2010
Apoptose e seus mecanismos reguladores são eventos fisiológicos cruciais para a manutenção da homeostase placentária, e o desequilíbrio desses processos pode comprometer a função placentária e, consequentemente, o sucesso da gravidez.
K.K.O.L. Meça, A.S. Martins, H.L Del Puerto, A.C. Vasconcelos   +3 more
doaj   +1 more source

Enfortumab vedotin‐induced cutaneous eruption: Ring mitotic figures as a distinctive histopathologic feature

Journal of Cutaneous Pathology, Volume 51, Issue 11, Page 847-851, November 2024.
Abstract Enfortumab vedotin (EV), a nectin‐4‐binding agent that affects microtubules, has become standard therapy for advanced urothelial carcinoma. The agent, now given in combination with pembrolizumab, frequently induces cutaneous reactions. Here, we report a severe EV‐induced cutaneous eruption.
Catherine Sport, Rebecca C. Clawson, Lauren E. Tisdale, John W. Melson, Mark C. Mochel   +4 more
wiley   +1 more source