Results 51 to 60 of about 22,852 (212)

Die Rolle des Proteins DEDD in Apoptose [PDF]

, 2001
In den vergangenen Jahren sind verschiedene Aspekte des Apoptose-Signalwegs detailliert untersucht worden. Spezialisierte Protein/Protein-Interaktionsdomänen, wie die Todeseffektor-Domäne („death effector domain“, DED), kennzeichnen Moleküle, die ...
Schickling, Olaf
core   +1 more source

Untersuchungen am Kernporen-Komplex während der Apoptose

, 2004
Die Behandlung von HeLa 229-Zellen mit TRAIL oder Etoposid führte zu einer charakteristischen apoptotischen Morphologie, zur proteolytischen Aktivierung der Exekutionscaspasen 3 und 7 sowie zu oligonukleosomaler DNA Fragmentierung.
Patre, Monika
core   +1 more source

Apoptose e maturação placentária bovina: um estudo imunohistoquímico e morfométrico

Pesquisa Veterinária Brasileira, 2016
Resumo: A liberação da placenta após o parto envolve a perda da adesão materno-fetal e ocorre somente após a maturação completa do placentoma, que está relacionada com a diminuição da celularidade dos tecidos fetal e materno. A apoptose é requerida tanto
Tatiane F. Carvalho, Núbia Braga Pereira, Camila Raianna Justiniana Rocha, Camila Couto Figueiredo, Milene Alvarenga Rachid, Anilton C. Vasconcelos   +5 more
doaj   +1 more source

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia–reperfusion injury

Experimental Physiology, Volume 111, Issue 8, Page 3557-3569, 1 August 2026.
Abstract Despite advancements in reperfusion therapy, myocardial ischaemia–reperfusion (IR) injury remains a major clinical challenge. This study investigated whether a novel dual‐target pre‐conditioning strategy using sinomenine and irisin could enhance myocardial resistance against IR injury. Ninety male Sprague–Dawley rats were utilized.
Lianjun Wu, Sining Bi, Amany Belal, Zhuzhu Liu   +3 more
wiley   +1 more source

Understanding the mechanisms of glutamine action in critically ill patients

Anais da Academia Brasileira de Ciências, 2010
Glutamine (Gln) is an important energy source and has been used as a supplementary energy substrate. Furthermore, Gln is an essential component for numerous metabolic functions, including acid-base homeostasis, gluconeogenesis, nitrogen transport and ...
Gisele P. Oliveira, Cristina M. Dias, Paolo Pelosi, Patricia R.M. Rocco   +3 more
doaj   +1 more source

Extracellular vesicles derived from immobilization‐induced atrophic muscle of male mice contain distinct microRNA profiles and impact mRNA profiles in brain neurons

Physiological Reports, Volume 14, Issue 16, August 2026.
Abstract Muscle atrophy caused by inactivity leads to declines in multiple physiological functions, including brain function. Although skeletal muscle is known to secrete extracellular vesicles (EVs) such as exosomes, how inactivity‐induced muscle atrophy alters the properties and functions of these EVs remains unclear.
Noriaki Kawanishi, Shuichi Machida, Katsuhiko Suzuki   +2 more
wiley   +1 more source

Effects of Panax ginseng, Turnera diffusa and Heteropterys tomentosa extracts on hippocampal apoptosis of aged rats

Einstein (São Paulo)
OBJECTIVE: To verify if the medicinal plants Panax ginseng C.A. Mey, Turnera diffusa Willd. ex Schult., and Heteropterys tomentosa O. Mach., which are amply used by the population as tonics and cognition enhancers, could have a protective effect on cell ...
Andréia Gomes Bezerra, Soraya Soubhi Smaili, Guiomar Silva Lopes, Elisaldo Araújo Carlini   +3 more
doaj   +1 more source

Caspase-3 activation and increased procollagen type I in irradiated hearts

Anais da Academia Brasileira de Ciências, 2013
The caspase-3-cleaved presence was evaluated in this study in the heart of irradiated rats, during the decline of ventricular function. Female Wistar rats were irradiated with a single dose of radiation (15 Gy) delivered directly to the heart and the ...
Samara C. Ferreira-Machado, Camila Salata, Nazareth N. Rocha, Alexandre F.S. Corrêa, Suzana Côrte-Real, Antônio A.F. Peregrino, Vera M.A. de Campos, Cherley B.V. Andrade, Mario Bernardo-Filho, Januário B. Cabral-Neto, Carlos E. Dealmeida   +10 more
doaj   +1 more source

FURIN induces vascular endothelial cell death and efferocytosis through enzymatic cleavage of thrombospondin‐1

The Journal of Physiology, Volume 604, Issue 14, Page 5874-5891, 15 July 2026.
Abstract figure legend FURIN induces vascular endothelial cell (VEC) death and efferocytosis through enzymatic cleavage of thrombospondin‐1 (THBS1). FURIN interacts with THBS1 to induce VEC apoptosis and efferocytosis, resulting in increased endothelial permeability.
Runji Chen, Daifei Shen, Amandine Mahieux, Dedrick Song, Shiwan Wu, Xiaoxin Huang, Xu Yang, Kunwei Chen, David G. McVey, Elisa A. Liehn, Roshni R. Singaraja, Shu Ye   +11 more
wiley   +1 more source

Der Einfluss der Deubiquitinase Usp27x auf die zelluläre Apoptose

, 2021
Das Ubiquitin-Proteasom-System (UPS) ist ein wichtiger Mechanismus der Regulation verschiedener Signalwege innerhalb der Zelle, wie z.B. der Apoptose und damit auch verschiedener pathophysiologi-scher Vorgänge, wie etwa der Entartung von Zellen.
Alber, Claudia
core   +1 more source