Results 51 to 60 of about 1,705,451 (305)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis [PDF]

, 2011
Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Contrant, M, Johanna Viiliäinen, Vladimir Benes, Päivi M. Ojala, Voinnet Olivier, Gros, Frédéric, Voinnet, Olivier, Viiliainen, J, Mihaela Zavolan, Benes, Vladimir, Haas Juergen G., Suffert, G, Georg Malterer, Guillaume Suffert, Malterer, G, Frédéric Gros, Gros Frédéric, Ojala, Päivi M, Viiliäinen, Johanna, Suffert, Guillaume, Olivier Voinnet, Hausser Jean, Fender, A, Malterer Georg, Benes, V, Zavolan Mihaela, Ojala Päivi M., Haas, JG, Päivi M Ojala, Hausser, J, Viiliäinen Johanna, Zavolan, Mihaela, Hausser, Jean, Voinnet, O, Suffert Guillaume, Maud Contrant, Pfeffer Sébastien, Haas, Jürgen G., Zavolan, M, Jean Hausser, Tomi Ivacevic, Contrant Maud, Malterer, Georg, Benes Vladimir, Sébastien Pfeffer, Fender Aurélie, Haas, Juergen G, Ivacevic, T, Ojala, PM, Juergen G Haas, Ivacevic, Tomi, Aurélie Fender, Fender, Aurélie, Ojala, Päivi M., Pfeffer, Sébastien, Gros, F, Pfeffer, S, Contrant, Maud, Juergen G. Haas, Ivacevic Tomi, Haas, Juergen G.   +60 more
core   +1 more source

Advances in Lung Stem Cells and Lung Cancer Stem Cells

Chinese Journal of Lung Cancer, 2015
Cancer stem cells (CSCs) are emerging as a hot topic for cancer research. Lung CSCs share many characteristics with normal lung stem cells (SCs), including self-renewal and multi-potency for differentiation.
Huijing YIN, Jiong DENG
doaj   +1 more source

A novel method for genetic transformation of yeast cells using oligoelectrolyte polymeric nanoscale carriers

BioTechniques, 2013
The genetic transformation of target cells is a key tool in modern biological research, as well as in many gene therapy and biotechnology applications. Here we describe a new method for delivery of DNA into several industrially important species of yeast,
Yevhen Filyak, Nataliya Finiuk, Nataliya Mitina, Oksana Bilyk, Vladimir Titorenko, Olesya Hrydzhuk, Alexander Zaichenko, Rostyslav Stoika   +7 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]

, 2011
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Francis, S. E., Calogero Tulone, Read, R. C., Sheila E. Francis, Mitchell, T.J., Read Robert C., Benny Chain, Marriott, Helen M, Deretic, V., Dockrell, David H, Marriott, H.M., Francis, Sheila E, Dockrell, David H., Whyte, M.K.B., Martin A. Bewley, Mitchell Timothy J., Timothy J Mitchell, Whyte, Moira K B, Kroemer, G., Chain, B., Moira K. B. Whyte, Helen M Marriott, Sheila E Francis, Tulone Calogero, Robert C Read, Bewley, M.A., Dockrell, D.H., Whyte Moira K. B., Whyte, Moira K. B., Marriott Helen M., Read, Robert C., Marriott, H. M., Chain, Benny, Tulone, C., Read, R.C., Mitchell, Timothy J., Whyte, Moira K.B., David H. Dockrell, Mitchell, Timothy J, Francis Sheila E., David H Dockrell, Kroemer, Guido, Moira K B Whyte, Marriott, Helen M., Chain Benny, Mitchell, T. J., Timothy J. Mitchell, Bewley, Martin A, Dockrell, D. H., Read, Robert C, Tulone, Calogero, Francis, S.E., Robert C. Read, Dockrell David H., Bewley, Martin A., Martin A Bewley, Helen M. Marriott, Bewley, M. A., Dockrell, David, Bewley Martin A., Whyte, M. K. B., Guido Kroemer, Francis, Sheila E., Kroemer Guido   +63 more
core   +1 more source

Structural Basis of a Novel Agonistic Anti-OX40 Antibody

Biomolecules, 2022
Agonistic antibodies targeting co-stimulating receptor OX40 on T cells are considered as important as (or complementary to) the immune checkpoint blockers in cancer treatment.
Jing Zhang, Xiaoyong Jiang, Han Gao, Fei Zhang, Xin Zhang, Aiwu Zhou, Ting Xu, Haiyan Cai   +7 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection [PDF]

, 2009
: Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis ...
Kepp, Oliver, Yuri Churin, Nikolaus Machuy, Kathleen Gottschalk, Kepp, O., Gottschalk, K., Machuy, Nikolaus, Kroemer, G., Oliver Kepp, Gottschalk, Kathleen, Thomas Rudel, Rajalingam, K., Churin, Yuri, Rudel, T., Churin, Y., Rudel, Thomas, Volker Brinkmann, Krishnaraj Rajalingam, Machuy, N., Brinkmann, Volker, Rajalingam, Krishnaraj, Brinkmann, V., Guido Kroemer, Kroemer, Guido   +23 more
core   +2 more sources