Results 51 to 60 of about 1,587,813 (316)

Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma

Journal of Experimental & Clinical Cancer Research, 2022
Background Medulloblastoma is the most common malignant pediatric brain tumor and group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis.
Meng Li, Yujie Han, Chaochen Wang, Wenfeng Kang, Wenyan Jiang, Lei Zhang, Yujie Tang   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21(waf1/cip1) [PDF]

, 2001
Background/Aims: We investigated the effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone on growth and TRAIL-induced apoptosis in carcinoid cells.
Göke, Burkhard, Göke, Rüdiger, Chen, Youhai, El-Deiry, Wafik S., Göke, Alexandra   +4 more
core   +1 more source

Advances in Lung Stem Cells and Lung Cancer Stem Cells

Chinese Journal of Lung Cancer, 2015
Cancer stem cells (CSCs) are emerging as a hot topic for cancer research. Lung CSCs share many characteristics with normal lung stem cells (SCs), including self-renewal and multi-potency for differentiation.
Huijing YIN, Jiong DENG
doaj   +1 more source

Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

eLife, 2013
Apoptotic cells can produce signals to instruct cells in their local environment, including ones that stimulate engulfment and proliferation. We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same ...
Ainhoa Pérez-Garijo, Yaron Fuchs, Hermann Steller   +2 more
doaj   +1 more source

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Biomarker Research, 2020
Background Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. Methods We established inducible transgene expression in
Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells [PDF]

, 2008
Chlamydia are obligate intracellular bacteria that cause variety of human diseases. Host cells infected with Chlamydia are protected against many different apoptotic stimuli.
Manu Sharma, Christopher J Froelich, Oswald Monique, Sharma Manu, Lohmann, C., Oswald, M., Christine Lohmann, Sharma, Manu, Thomas Rudel, Froelich, C., Sharma, M., Monique Oswald, Froelich, Christopher J., Oliver Thieck, Rajalingam, Krishnaraj, Rudel Thomas, Thieck Oliver, Thieck, Oliver, Oswald, Monique, Froelich Christopher J., Rajalingam, K., Lohmann Christine, Rudel, T., Thieck, O., Rudel, Thomas, Krishnaraj Rajalingam, Rajalingam Krishnaraj, Lohmann, Christine   +27 more
core   +2 more sources

A novel method for genetic transformation of yeast cells using oligoelectrolyte polymeric nanoscale carriers

BioTechniques, 2013
The genetic transformation of target cells is a key tool in modern biological research, as well as in many gene therapy and biotechnology applications. Here we describe a new method for delivery of DNA into several industrially important species of yeast,
Yevhen Filyak, Nataliya Finiuk, Nataliya Mitina, Oksana Bilyk, Vladimir Titorenko, Olesya Hrydzhuk, Alexander Zaichenko, Rostyslav Stoika   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source