Results 41 to 50 of about 1,705,451 (305)

The meaning of death : evolution and ecology of apoptosis in protozoan parasites [PDF]

, 2011
This work was funded by the Wellcome Trust (SER: WT082234MA; http://www.wellcome.ac.uk/), the NERC (LCP: studentship), the Royal Society of London (AG: University Research Fellowship; http://royalsociety.org/), and Balliol College, University of Oxford ...
Colegrave, Nick, Sarah E Reece, Sarah E. Reece, Pollitt Laura C., Colegrave Nick, Reece, Sarah E., Gardner, A, Pollitt, Laura C., Colegrave, N, Laura C Pollitt, Nick Colegrave, Gardner Andy, Gardner, Andy, Pollitt, LC, Reece, SE, Reece Sarah E., Andy Gardner, Laura C. Pollitt   +17 more
core   +1 more source

Meru co-ordinates spindle orientation with cell polarity and cell cycle progression

The EMBO Journal
Correct mitotic spindle alignment is essential for tissue architecture and plays an important role in cell fate specification through asymmetric cell division.
Melissa M McLellan, Birgit L Aerne, Jennifer J Banerjee Dhoul, Maxine V Holder, Tania Auchynnikava, Nicolas Tapon   +5 more
doaj   +1 more source

Comprehensive Mutation Profiling of Colorectal Cancer Patients With Lung or Liver Metastasis by Targeted Next-Generation Sequencing

Technology in Cancer Research & Treatment, 2023
Objectives Primary tumor tissue is often analyzed to search for predictive biomarkers and DNA-guided personalized therapies, but there is an incomplete understanding of the discrepancies in the genomic profiles between primary tumors and metastases, such
Chun-Ting Hu PhD, Jing-Long Wang MD, Ting Hou MD, Zhao-Wen Yan MD, Li-Dong Zu PhD, Guo-Hui Fu PhD, Wei-Wei Shen PhD   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells

Leukemia Research Reports, 2014
The anti-apoptotic proteins Bcl-XL and Bcl-2 are abundantly expressed in hematopoietic stem cells and/or progenitor cells. Furthermore, leukemic cells expressing these proteins are enriched in minimal residual disease cell populations.
Denis V. Baev, Janusz Krawczyk, Michael O׳Dwyer, Eva Szegezdi   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells [PDF]

, 2006
Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood.
Manu Sharma, Nicole Paland, Nikolaus Machuy, Thieck, Oliver, Oswald, Monique, Robert Hurwitz, Oswald, M., Machuy, Nikolaus, Sharma, Manu, Thomas Rudel, Rajalingam, K., Sharma, M., Monique Oswald, Rudel, T., Paland, Nicole, Thieck, O., Rudel, Thomas, Oliver Thieck, Hurwitz, Robert, Krishnaraj Rajalingam, Paland, N., Machuy, N., Rajalingam, Krishnaraj, Hurwitz, R.   +23 more
core   +2 more sources

Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

eLife, 2013
Apoptotic cells can produce signals to instruct cells in their local environment, including ones that stimulate engulfment and proliferation. We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same ...
Ainhoa Pérez-Garijo, Yaron Fuchs, Hermann Steller   +2 more
doaj   +1 more source

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Biomarker Research, 2020
Background Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. Methods We established inducible transgene expression in
Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias   +10 more
doaj   +1 more source

Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma

Journal of Experimental & Clinical Cancer Research, 2022
Background Medulloblastoma is the most common malignant pediatric brain tumor and group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis.
Meng Li, Yujie Han, Chaochen Wang, Wenfeng Kang, Wenyan Jiang, Lei Zhang, Yujie Tang   +6 more
doaj   +1 more source