Results 21 to 30 of about 1,587,813 (316)
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
International Journal of Cell Biology, 2010 During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death.
Sanjeev Gupta +6 more
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Molecular Therapy: Oncolytics, 2018 Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-α). SMCs synergize
Shawn T. Beug +6 more
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Recreating the Bone Marrow Microenvironment to Model Leukemic Stem Cell Quiescence
Frontiers in Cell and Developmental Biology, 2021 The main challenge in the treatment of acute myeloid leukemia (AML) is relapse, as it has no good treatment options and 90% of relapsed patients die as a result.
Eimear O’Reilly +8 more
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British Journal of Cancer, 2008 Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the drug development cycle, especially in the clinic. Selective activation of apoptosis is often cited as one of the major goals of cancer chemotherapy.
Ward, T. H. +7 more
openaire +3 more sources
Vitamin C inhibits endothelial cell apoptosis in congestive heart failure [PDF]
, 2001 Background - Proinflammatory cytokines like tumor necrosis factor- and oxidative stress induce apoptotic cell death in endothelial cells (ECs). Systemic inflammation and increased oxidative stress in congestive heart failure (CHF) coincide with enhanced ...
Dimmeler, S +9 more
core +1 more source
Nature Communications, 2023 The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the mammalian HOPS complex remains a challenge.
Shen Zhang +13 more
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Glutathione and apoptosis [PDF]
Free Radical Research, 2008 Apoptosis or programmed cell death represents a physiologically conserved mechanism of cell death that is pivotal in normal development and tissue homeostasis in all organisms. As a key modulator of cell functions, the most abundant non-protein thiol, glutathione (GSH), has important roles in cellular defense against oxidant aggression, redox ...
Magdalena L, Circu, Tak Yee, Aw
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Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis [PDF]
, 2005 Glucocorticoid-induced osteoporosis may be at least in part due to the increased apoptosis of osteocytes. To study the role of osteocyte apoptosis in glucocorticoid-induced osteoporosis, we isolated primary osteocytes from murine calvaria for the ...
Nars, M +6 more
core +1 more source
Nature Communications, 2018 IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to ...
Susan E. Logue +18 more
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Generation of Tumour-stroma Minispheroids for Drug Efficacy Testing
Bio-Protocol, 2017 The three-dimensional organisation of cells in a tissue and their interaction with adjacent cells and extracellular matrix is a key determinant of cellular responses, including how tumour cells respond to stress conditions or therapeutic drugs (Elliott ...
Mark Watters , Eva Szegezdi
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