Results 21 to 30 of about 1,705,451 (305)
Study on Apoptosis (6) : Effect of vitamin B6 on active oxygen - induced apoptosis in lymphocyte. [PDF]
, 2005 The mechanism of active oxygen induced - apoptosis in lymphocyte by vitamin B6 as compared with those by vitamin C was studied. The protective effect of vitamin B6 was dependent on concentration and occurred only in the millimolar concentration range. In
ドウケ, ショウコ +2 more
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RNA virus modulation of IFN, PI3K and apoptosis [PDF]
, 2009 Interferon (IFN) and phosphatidylinositol 3-kinase (PI3K) are apoptosis regulators that are targeted by viruses to promote survival of infected cells.
Killip, Marian J.
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Molecular Therapy: Oncolytics, 2018 Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-α). SMCs synergize
Shawn T. Beug +6 more
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Recreating the Bone Marrow Microenvironment to Model Leukemic Stem Cell Quiescence
Frontiers in Cell and Developmental Biology, 2021 The main challenge in the treatment of acute myeloid leukemia (AML) is relapse, as it has no good treatment options and 90% of relapsed patients die as a result.
Eimear O’Reilly +8 more
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Glutathione and apoptosis [PDF]
Free Radical Research, 2008 Apoptosis or programmed cell death represents a physiologically conserved mechanism of cell death that is pivotal in normal development and tissue homeostasis in all organisms. As a key modulator of cell functions, the most abundant non-protein thiol, glutathione (GSH), has important roles in cellular defense against oxidant aggression, redox ...
Magdalena L, Circu, Tak Yee, Aw
openaire +2 more sources
Nature Communications, 2023 The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the mammalian HOPS complex remains a challenge.
Shen Zhang +13 more
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Molecules, 2019 This study aims to determine the anti-carcinogenic effects of the proanthocyanidin-rich fraction (PRFR) obtained from red rice germ and bran extract on HepG2 cells.
Supranee Upanan +5 more
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Cells, 2023 Adult stem cells (ASCs) can be cultured with difficulty from most tissues, often requiring chemical or transgenic modification to achieve adequate quantities. We show here that mouse primary fibroblasts, grown in suspension, change from the elongated and
Behzad Yeganeh +4 more
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Serum deprivation induced apoptosis in macrophage is mediated by autocrine secretion of type IIFNs
, 2006 Apoptosis can be triggered by different forms of cellular stress. We here show that serum deprivation induces the expression and secretion of type I interferons and results in apoptosis in RAW 264.7 cell in a caspase dependent manner.
J. Wei +7 more
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Nature Communications, 2018 IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to ...
Susan E. Logue +18 more
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