Results 11 to 20 of about 1,587,813 (316)
Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]
, 2015 The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis +11 more
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Serum deprivation induced apoptosis in macrophage is mediated by autocrine secretion of type IIFNs [PDF]
, 2006 Apoptosis can be triggered by different forms of cellular stress. We here show that serum deprivation induces the expression and secretion of type I interferons and results in apoptosis in RAW 264.7 cell in a caspase dependent manner.
J. Wei +7 more
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Introduction to Apoptosis [PDF]
Diagnostic Molecular Pathology, 1995 Kerr and colleagues (II) coined the term" apoptosis" to designate a particular form of cell death distinct from necrosis. The salient features of apoptosis, which Kerr defined in histopathologic terms, were the breakup of individual cells into smaller, often round or ovoid cytoplasmic fragments containing pyknotic nuclear debris, called" apoptotic ...
Diaz-Cano, Salvador J., N Salomon, R
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Scientific Reports, 2021 CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia cells and xenografts derived thereof (PDX).
Wen-Hsin Liu +3 more
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Targeting apoptosis signaling in pancreatic cancer [PDF]
, 2011 The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis.
Simone Fulda, Fulda, Simone
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Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs) [PDF]
Cells, 2013 Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein-protein interaction.
Jean Berthelet, Laurence Dubrez
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Evasion of apoptosis as a cellular stress response in cancer [PDF]
, 2010 One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis can be part of a cellular stress response to ensure the cell's survival upon exposure to stressful stimuli.
Simone Fulda, Fulda, Simone
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Shifting the balance of mitochondrial apoptosis: therapeutic perspectives [PDF]
, 2012 Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death.
Simone Fulda +2 more
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Nature Communications, 2017 Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer ...
Shawn T. Beug +16 more
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Study on Apoptosis (6) : Effect of vitamin B6 on active oxygen - induced apoptosis in lymphocyte. [PDF]
, 2005 The mechanism of active oxygen induced - apoptosis in lymphocyte by vitamin B6 as compared with those by vitamin C was studied. The protective effect of vitamin B6 was dependent on concentration and occurred only in the millimolar concentration range. In
ドウケ, ショウコ +2 more
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