Results 61 to 70 of about 3,365,976 (292)

Macrophage signaling in HIV-1 infection

Retrovirology, 2010
The human immunodeficiency virus-1 (HIV-1) is a member of the lentivirus genus. The virus does not rely exclusively on the host cell machinery, but also on viral proteins that act as molecular switches during the viral life cycle which play significant ...
Abbas Wasim, Khan Kashif, Gras Gabriel, Herbein Georges   +3 more
doaj   +1 more source

BTat, a trans-acting regulatory protein, contributes to bovine immunodeficiency virus-induced apoptosis [PDF]

Cellular Microbiology, 2007
Bovine immunodeficiency virus (BIV) is a member of the lentivirus subfamily of retroviruses highly related to human immunodeficiency virus in morphologic, antigenic and genomic features. BIV is known to induce chronic pathological changes in infected hosts, which are often associated with the development of immune-mediated lesions.
Chenghao, Xuan, Wentao, Qiao, Jian, Li, Guoyuan, Peng, Min, Liu, Qimin, Chen, Jun, Zhou, Yunqi, Geng   +7 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effects of L-Leu-L-Leu peptide on growth, proliferation, and apoptosis in broiler intestinal epithelial cells

Poultry Science
: Small peptides are nutrients and bioactive molecules that have dual regulatory effects on nutrition and physiology. They are of great significance for maintaining the intestinal health and production performance of broilers.
Jing Liang, Baolong Du, Minyan Wan, Likun Sun, Shizhen Qin, Fang Nian, Defu Tang   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The role of the notch signalling pathway in vascular smooth muscle cell apoptosis [PDF]

, 2004
The Notch signalling system is a highly conserved method of cell-to-cell communication involved in cell fate decisions in many cell types. Until recently, the importance of the Notch signalling pathway was recognized in the embryonic but not in the adult
Sweeney, Catherine Helena
core   +2 more sources

Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]

, 2012
Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
core   +1 more source

Differences between the CD34+ and CD34- blast compartments in apoptosis resistance in acute myeloid leukemia

Haematologica, 2003
BACKGROUND AND OBJECTIVES: Altered expression of members of the Bcl-2 family might account for the observed apoptosis resistance to chemotherapy in acute myeloid leukemia (AML). Given the poor prognosis associated with CD34+ expression in AML, we studied
A van Stijn, MA van der Pol, A Kok, PM Bontje, GM Roemen, RH Beelen, GJ Ossenkoppele, GJ Schuurhuis   +7 more
doaj  

Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes

Journal of Lipid Research, 2001
It is well established that during the execution of the apoptotic cascade, activated caspase 3 releases sterol regulatory element-binding proteins (SREBP) from the membrane of the endoplasmic reticulum in a proteolytic reaction that is distinct from ...
Maureen E. Higgins, Yiannis A. Ioannou
doaj   +1 more source